Pregnancy-Associated Plasma Protein A, Pappalysin 1 Proteins (PAPPA)

PAPPA encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Additionally we are shipping PAPPA Antibodies (389) and PAPPA Kits (63) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PAPPA 18491 Q8R4K8
Rat PAPPA PAPPA 313262  
PAPPA 5069 Q13219
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Top PAPPA Proteins at antibodies-online.com

Showing 10 out of 23 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,984.89
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,984.89
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$618.00
Details
Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 15 to 18 Days
$685.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Escherichia coli (E. coli) Human Un-conjugated 10 μg Log in to see 11 to 12 Days
$220.80
Details
Escherichia coli (E. coli) Human His tag   50 μg Log in to see 15 to 18 Days
$695.00
Details
Escherichia coli (E. coli) Human His tag   1 mg Log in to see 2 to 3 Days
$6,350.77
Details
Human Human Un-conjugated   100 μg Log in to see 6 to 8 Days
$312.43
Details

PAPPA Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , , , ,
, ,

More Proteins for Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) Interaction Partners

Mouse (Murine) Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) interaction partners

  1. Inducible knockdown of PAPP-A gene expression in adult female mice extends life span.

  2. Intrinsic mitochondrial oxidative capacity was significantly increased in skeletal muscle of aged PAPP-A KO compared to WT mice. Moreover, 18-month-old PAPP-A KO mice exhibited significantly enhanced endurance running on a treadmill. Thus, PAPP-A deficiency in mice is associated with indices of healthy skeletal muscle function with age.

  3. Snell, GHKRO, and PAPPA-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT (show MGMT Proteins)) and N-myc downstream-regulated gene 1 (NDRG1 (show NDRG1 Proteins)).

  4. STC2 (show STC2 Proteins) is involved in regulating PAPP-A activity during the development of atherosclerosis

  5. Study demonstrates proof-of-principle and provides feasibility for a novel therapeutic strategy to inhibit atherosclerotic plaque burden by selective targeting of PAPP-A.

  6. stimulation of PAPP-A expression by intermittent PTH (show PTH Proteins) treatment contributes to PTH (show PTH Proteins) bone anabolism in mice

  7. PAPP-A affects fascicle structure, thereby affecting tendon phenotype.

  8. PAPP-A has a role in development of advanced plaque with necrotic cores and buried fibrous caps (show CAPS Proteins) in the brachiocephalic artery

  9. these data indicate preferential impact of PAPP-A deficiency on visceral fat in the mouse that is associated with enhanced insulin receptor (show INSR Proteins) signaling

  10. Studies show a conditional PAPP-A knockout (KO) model for efficacy of tamoxifen-induced floxed PAPP-A excision in various tissues and indicate a significant reduction of neointimal formation after unilateral carotid artery ligation.

Human Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) interaction partners

  1. Serum PAPP-A at third trimester of pregnancy was not associated with late-onset pre-eclampsia and intrauterine growth retardation after 34weeks of pregnancy.

  2. Elevated PROK1 (show Prok1 Proteins) in the first pregnancy trimester is a more effective marker than PAPP-A in the prediction of pre-eclampsia and fetal growth restriction.

  3. The findings suggest a possible pathophysiological link between the development of Fetal growth restriction and the expression of PAPPA, PAPPA2 (show PAPPA2 Proteins) and PLAC-1 (show PLAC1 Proteins).

  4. Data suggest that PGF (show PGF Proteins) and PAPPA serve as serum biomarkers for early diagnosis of gestational hypertension. These studies were conducted at antenatal clinics in Ghana using blood from women between 8 and 13 weeks gestation. (PGF (show PGF Proteins) = placental growth factor (show PGF Proteins); PAPPA = pregnancy-associated plasma protein-A)

  5. Pregnancy associated plasma protein-A (PAPP-A) appears to be a potentially useful biomarker for short-term risk stratification of patients presenting with chest pain of ischemic origin (Review).

  6. These data suggested that hsa_circ_0004904 and hsa_circ_0001855 combined with PAPP-A might be promising biomarkers for the detection of Preeclampsia. Bioinformatics analysis predicted that hsa_circ_0004904 and hsa_circ_0001855 miRNA sponges directly target PAPP-A.

  7. Studied the role of pregnancy-associated plasma protein A (PAPP-A) in the outcome of ischemic cerebrovascular disease.

  8. PAPP-A and ProMBP are associated with increased risk of death in heart failure patients.

  9. PAPP-A C/C genotypes were more frequent among mothers with gestational diabetes than in control.

  10. Elevated PAPP-A compared to other risk factors was a stronger predictor for future CV events 2 years post ACS in patients with type 2 diabetes mellitus.

Cow (Bovine) Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) interaction partners

  1. study determined IGFR1 (show IGF1R Proteins) and PAPP-A expression both in follicles at different stages of development and in ovarian cysts; data indicate that animals with cystic ovarian disease (COD (show SNRPB Proteins)) have an altered regulation of the IGF system in the ovary and thus allow postulating IGFR1 (show IGF1R Proteins) expression and PAPP-A secretion as a modulator of IGF1 (show IGF1 Proteins) in cattle with COD (show SNRPB Proteins)

  2. in preovulatory follicles, PAPP-A is responsible for IGF-dependent IGFBP-2 (show IGFBP2 Proteins) degradation

  3. concluded that changes in granulosa cell PAPP-A mRNA levels do not occur during final preovulatory follicular development in cattle

PAPPA Protein Profile

Protein Summary

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses.

Gene names and symbols associated with PAPPA

  • pappalysin 1 (PAPPA)
  • pregnancy-associated plasma protein A (Pappa)
  • pappalysin 1 (Pappa1)
  • pappalysin 1 (Pappa)
  • 8430414N03Rik protein
  • ASBABP2 protein
  • DIPLA1 protein
  • IGFBP-4ase protein
  • PAG1 protein
  • PAPA protein
  • PAPP-A protein
  • Pappa protein
  • PAPPA1 protein

Protein level used designations for PAPPA

IGF-dependent IGFBP-4 protease , insulin-like growth factor-dependent IGF-binding protein 4 protease , pappalysin-1 , aspecific BCL2 ARE-binding protein 2 , differentially placenta 1 expressed protein , insulin-like growth factor-dependent IGF binding protein-4 protease , pregnacy-associated plasma protein A , PAPPA-like protein , pregnancy-associated plasma protein A-like protein , cleaves insulin-like binding protein-4 (IGFBP-4) , metalloprotease

GENE ID SPECIES
100033920 Equus caballus
18491 Mus musculus
313262 Rattus norvegicus
5069 Homo sapiens
481692 Canis lupus familiaris
282647 Bos taurus
100734958 Cavia porcellus
417245 Gallus gallus
397219 Sus scrofa
443157 Ovis aries
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