Pregnancy-Associated Plasma Protein A, Pappalysin 1 Proteins (PAPPA)

Mouse (Murine) Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) interaction partners

1. Inducible knockdown of PAPP-A gene expression in adult female mice extends life span.

2. Intrinsic mitochondrial oxidative capacity was significantly increased in skeletal muscle of aged PAPP-A KO compared to WT mice. Moreover, 18-month-old PAPP-A KO mice exhibited significantly enhanced endurance running on a treadmill. Thus, PAPP-A deficiency in mice is associated with indices of healthy skeletal muscle function with age.

3. Snell, GHKRO, and PAPPA-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT (show MGMT Proteins)) and N-myc downstream-regulated gene 1 (NDRG1 (show NDRG1 Proteins)).

4. STC2 (show STC2 Proteins) is involved in regulating PAPP-A activity during the development of atherosclerosis

5. Study demonstrates proof-of-principle and provides feasibility for a novel therapeutic strategy to inhibit atherosclerotic plaque burden by selective targeting of PAPP-A.

6. stimulation of PAPP-A expression by intermittent PTH (show PTH Proteins) treatment contributes to PTH (show PTH Proteins) bone anabolism in mice

7. PAPP-A affects fascicle structure, thereby affecting tendon phenotype.

8. PAPP-A has a role in development of advanced plaque with necrotic cores and buried fibrous caps (show CAPS Proteins) in the brachiocephalic artery

9. these data indicate preferential impact of PAPP-A deficiency on visceral fat in the mouse that is associated with enhanced insulin receptor (show INSR Proteins) signaling

10. Studies show a conditional PAPP-A knockout (KO) model for efficacy of tamoxifen-induced floxed PAPP-A excision in various tissues and indicate a significant reduction of neointimal formation after unilateral carotid artery ligation.

Human Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) interaction partners

1. Studied the role of pregnancy-associated plasma protein A (PAPP-A) in the outcome of ischemic cerebrovascular disease.

2. PAPP-A and ProMBP are associated with increased risk of death in heart failure patients.

3. PAPP-A C/C genotypes were more frequent among mothers with gestational diabetes than in control.

4. Elevated PAPP-A compared to other risk factors was a stronger predictor for future CV events 2 years post ACS in patients with type 2 diabetes mellitus.

5. PAPP-A, like CCS (show CCS Proteins) and CIMT, is a parameter that can be used to detect subclinical atherosclerosis.

6. Results suggest that links between PAPP-A concentrations in early pregnancy and subsequent glucose concentrations and blood pressures may be mediated by changes in insulin (show INS Proteins) sensitivity (and secretion).

7. Collectively, these results identify PAPP-A as a pregnancy-dependent oncogene (show RAB1A Proteins) while also showing that extended lactation is protective against PAPP-A-mediated carcinogenesis.

8. Lower PlGF (show PGF Proteins) and higher PAPP-A and free beta-hCG (show CGA Proteins) levels were found in the fetal circulation of near-term severe preeclamptic pregnancies

9. PAPP-A 1224 SNP has a significant effect on the level and activity of PAPP-A in human follicles, suggesting that the follicular fluid level of bioactive insulin (show INS Proteins)-like growth factor depends on the genotype.

10. This study demonstrated no association between PAPP-A gene rs7020782 polymorphism and Preeclampsia (PE) and intrauterine growth restriction.

Cow (Bovine) Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) interaction partners

1. study determined IGFR1 (show IGF1R Proteins) and PAPP-A expression both in follicles at different stages of development and in ovarian cysts; data indicate that animals with cystic ovarian disease (COD (show SNRPB Proteins)) have an altered regulation of the IGF system in the ovary and thus allow postulating IGFR1 (show IGF1R Proteins) expression and PAPP-A secretion as a modulator of IGF1 (show IGF1 Proteins) in cattle with COD (show SNRPB Proteins)

2. in preovulatory follicles, PAPP-A is responsible for IGF-dependent IGFBP-2 degradation

3. concluded that changes in granulosa cell PAPP-A mRNA levels do not occur during final preovulatory follicular development in cattle