Premelanosome Protein (PMEL) ELISA Kits

PMEL encodes a melanocyte-specific type I transmembrane glycoprotein. Additionally we are shipping PMEL Antibodies (216) and PMEL Proteins (12) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
PMEL 6490 P40967
PMEL 20431  
Anti-Rat PMEL PMEL 362818  
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Top PMEL ELISA Kits at antibodies-online.com

Showing 7 out of 15 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 0.057 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests 13 to 16 Days
$700.00
Details
Mouse
  96 Tests 2 to 3 Days
$713.90
Details
Rabbit 37.5 pg/mL 62.5-4000 pg/mL   96 Tests 12 to 14 Days
$715.00
Details
Chicken 0.094 ng/mL 0.156-10 ng/mL   96 Tests 12 to 14 Days
$715.00
Details
Pig 0.094 ng/mL 0.156-10 ng/mL   96 Tests 12 to 14 Days
$715.00
Details
Monkey 0.094 ng/mL 0.156-10 ng/mL   96 Tests 12 to 14 Days
$715.00
Details
Cow
  96 Tests 15 to 18 Days
$1,029.60
Details

Top referenced PMEL ELISA Kits

  1. Human PMEL ELISA Kit for Sandwich ELISA - ABIN414624 : Bande, Santiago, Mera, Piulats, Blanco, Rodríguez-Álvarez, Capeans, Piñeiro, Pardo: ME20-S as a Potential Biomarker for the Evaluation of Uveal Melanoma. in Investigative ophthalmology & visual science 2015 (PubMed)

More ELISA Kits for PMEL Interaction Partners

Human Premelanosome Protein (PMEL) interaction partners

  1. These results can give insight into how lysophospholipids might influence repeat domain of Pmel17 aggregation and can give some understanding of general protein-lipid interactions of amyloidogenic proteins.

  2. This report establishes variation in PMEL as a cause of pigment dispersion syndrom/Pigmentary glaucoma based on several mutually supporting lines of evidence. First, WES of two families affected by PDS/PG and having pedigrees consistent with dominant modes of inheritance led to identification of heterozygous non-synonymous variants in PMEL. We identified seven associated non-synonymous variants.

  3. silencing of PMEL suppressed melanization through activating lysosomes and degradation of tyrosinase by lysosomes.

  4. To provide a source of dual-specific T cells for ACT, we generated a transgenic mouse strain expressing a CAR specific for Her2 in leukocytes under the control of the vav promoter .This CAR mouse strain was bred onto the pMEL transgenic mouse strain, expressing a TCR specific for the premelanosome protein, gp100

  5. IMCgp100 (ImmTAC recognizing a peptide derived from the melanoma-specific protein, gp100, presented by HLA-A*0201) efficiently redirects and activates effector and memory cells from both CD8(+) and CD4(+) repertoires to kill melanoma cells.

  6. our work attempts to provide structural insights into the RPT domain structure and to elucidate its contribution to Pmel17 amyloid fibril formation.

  7. These findings help to clarify the mechanism of T-cell recognition of gp100 during melanoma responses and could direct the development of altered peptides for vaccination.

  8. Data suggest that the Kringle-like domain of PMEL facilitates post-endoplasmic reticulum processing of disulfide-bonded PMEL dimers and promotes formation of PMEL functional amyloid fibrillar structures within multivesicular endosomes.

  9. mutant N-terminally extended peptides exhibited significantly increased HLA-A*02:01 binding affinity and elicited CD8(+) T cell stimulation in vitro similar to the wtgp100209-217 epitope.

  10. Data indicate that repeat domain (RPT) derived from Pmel17 aggregation kinetics were influenced only by lysolipid-containing phospholipid vesicles.

  11. Melanosome-autonomous regulation of size and number: the OA1 receptor sustains PMEL expression.

  12. SIL-TAL1 rearrangement identifies a distinct subtype with inferior outcome which could allow for individual therapeutic stratification for T-ALL patients.

  13. the molecular basis for the distinct trafficking and morphogenetic properties of PMEL and GPNMB is the PKD domain

  14. Data indicat that the N-terminal region of PMEL/Pmel17 is essential for the formation of melanosomal fibrils.

  15. BACE2 cleaves the integral membrane form of PMEL within the juxtamembrane domain, releasing the PMEL luminal domain into endosomal precursors for the formation of amyloid fibrils and downstream melanosome morphogenesis.

  16. The recombinant Pmel 17 plasmids were right as we expected by DNA sequencing

  17. The most significant single-nucleotide polymorphism in the 12q13.2 locus is located immediately upstream of the promoter region of PMEL for vitiligo in Han Chinese.

  18. An antibody drug conjugate reactive with PMEL17 exhibits target-dependent tumor cell killing in vitro and in vivo.

  19. This is a review on two human amyloidogenic polypeptides, one associated with Parkinson's disease, alpha-synuclein (alpha-syn), and the other important for melanin synthesis, the repeat domain (RPT) from Pmel17.[Review]

  20. MART-1- and gp100-expressing and -non-expressing melanoma cells are equally proliferative in tumors and clonogenic in vitro.

Mouse (Murine) Premelanosome Protein (PMEL) interaction partners

  1. These findings indicated that overexpression of miR-136 inhibits melanoma cell epithelial-mesenchymal transition, proliferation, migration, invasion, and promotes apoptosis by targetting PMEL through down-regulation of the Wnt signaling pathway.

  2. Prophylactic and therapeutic vaccinations of mice with MCMV-gp100KGP effectively protected mice from highly aggressive lung B16-F10 melanoma, and the protection was mediated by gp100-specific CD8(+) T cells

  3. Melanosome-autonomous regulation of size and number: the OA1 receptor sustains PMEL expression.

  4. the BACE1 homologue BACE2 processes PMEL to generate functional amyloids

  5. A long-peptide vaccine formulation of 20-mer synthetic peptide elicits gp100-specific CD8 T cells from the endogenous repertoire.

  6. Despite a mild effect on visible pigmentation, inactivation of Pmel led to a substantial reduction in eumelanin content in hair, which demonstrates that PMEL has a critical role for maintaining efficient epidermal pigmentation.

  7. Pmel17 gene expression is Microphthalmia-associated transcription factor-dependent in the mouse embryo.

  8. These data reveal a dual sorting defect in a natural mutant of Pmel17 and support a requirement of endocytic trafficking in Pmel17 fibril formation.

  9. The silver (Si) protein catalyzes the polymerization of 5,6-dihydroxyindole-2-carboxylic acid to melanin.

Cow (Bovine) Premelanosome Protein (PMEL) interaction partners

  1. Six solid colors occur in Highland cattle: black, dun, silver dun and red, yellow, and white. These six coat colors are explained by a non-epistatic interaction of the genotypes at the MC1R and PMEL genes.

  2. no convincing recombination events were found between the SILV c.64A>G mutation and the Dc locus

  3. the complex expression pattern of the bovine SILV gene in pigmented and non-pigmented tissues

Horse (Equine) Premelanosome Protein (PMEL) interaction partners

  1. In this study, ultrasonography was useful to identify uveal cysts in PMEL17 mutant carriers and to assess anterior chamber depth.

  2. The results of both clinical evaluation and genotyping resembled the previously described Multiple Congenital Ocular Anomalies of both Rocky Mountain and Kentucky Mountain Saddle horses.

  3. mutation segregating with multiple congenital ocular anomalies (MCOA) syndrome in Icelandic horses

  4. The MCOA locus for Equine Multiple Congenital Ocular Anomalies syndrome maps to horse chromosome 6.

Zebrafish Premelanosome Protein (PMEL) interaction partners

  1. melanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 and PMEL.

  2. A mutation in silva leads to defects in melansome biogenesis and alterations in the visual system in the mutant fading vision.

PMEL Antigen Profile

Antigen Summary

This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with Premelanosome Protein (PMEL) ELISA Kits

  • premelanosome protein (PMEL) antibody
  • premelanosome protein (Pmel) antibody
  • premelanosome protein a (pmela) antibody
  • cb397 antibody
  • D10H12S53E antibody
  • D12S53E antibody
  • D12S53Eh antibody
  • fdv antibody
  • gp87 antibody
  • gp100 antibody
  • ME20 antibody
  • ME20-M antibody
  • ME20M antibody
  • MMP115 antibody
  • P1 antibody
  • P100 antibody
  • pmel17 antibody
  • RPE1 antibody
  • sb:cb397 antibody
  • Si antibody
  • SIL antibody
  • Silv antibody
  • silva antibody
  • silver antibody
  • wu:fc11g11 antibody
  • wu:fj24g11 antibody
  • zgc:136622 antibody

Protein level used designations for Premelanosome Protein (PMEL) ELISA Kits

melanocyte protein PMEL , melanocyte protein Pmel 17 , melanocyte protein mel 17 , melanocytes lineage-specific antigen GP100 , melanoma-associated ME20 antigen , melanosomal matrix protein17 , silver locus protein homolog , silver, mouse, homolog of , melanocyte protein pmel 17 , silver locus protein , retinal pigment epithelial-specific protein , silver homolog , 115 kDa melanosomal matrix protein , PMEL17 protein , melanocyte protein 17 , premelanosomal protein , fading vision , melanosomal matrix protein , silver homolog a

GENE ID SPECIES
6490 Homo sapiens
20431 Mus musculus
281487 Bos taurus
362818 Rattus norvegicus
396007 Gallus gallus
481102 Canis lupus familiaris
594851 Sus scrofa
102176102 Capra hircus
100033885 Equus caballus
100347477 Oryctolagus cuniculus
321239 Danio rerio
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