Prodynorphin Proteins (PDYN)

The protein encoded by PDYN is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin.

list all proteins Gene Name GeneID UniProt
Human PDYN PDYN 5173 P01213
Mouse PDYN PDYN 18610  
Rat PDYN PDYN 29190  
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More Proteins for Prodynorphin (PDYN) Interaction Partners

Human Prodynorphin (PDYN) interaction partners

  1. Genetic and epigenetic factors within PDYN are related to risk for alcoholism.

  2. These results indicate that KOR (show OPRK1 Proteins) can form a heterodimer with B2R (show BDKRB2 Proteins) and this leads to increased protein kinase A activity by the CREB (show CREB1 Proteins) signaling pathway, leading to a significant increase in cell proliferation.

  3. This study found a significant haplotype-by-sex interaction, suggesting association with alcohol dependence in males but not females. The findings suggest that sex-dependent effects of PDYN variants in alcohol dependence are phenotype-specific.

  4. PDYN gene promoter polymorphism might contribute to familial-risk temporal lobe epilepsy. (Review, meta-analysis)

  5. The results demonstrate that DYN 1-17 and certain N-terminal fragments, produced in an inflamed environment, play an anti-inflammatory role by inhibiting NF-kappaB (show NFKB1 Proteins)/p65 (show GORASP1 Proteins) translocation.

  6. Enhanced event-related potentials amplitudes suggest a hyper-active performance monitoring system in high PDYN expression individuals, and this might also be an indicator of a higher risk for internalizing disorders

  7. This study generated the first mouse model for SCA23 and shown that mice expressing PDYN-R212W recapitulate many characteristics of the human phenotype of SCA23

  8. Studied differential DNA-protein interactions of PDYN and OPRK1 (show OPRK1 Proteins) SNPs significantly associated with alcohol dependence.

  9. REST represses PDYN expression in SH-SY5Y cells and the adult human brain and may have implications for mental health and brain/mental disorders.

  10. This study demonistratedn that Neurocognitive and neuroinflammatory correlates of PDYN mRNA expression in the anterior cingulate in postmortem brain of HIV-infected subjects.

Mouse (Murine) Prodynorphin (PDYN) interaction partners

  1. Mechanical allodynia produced by monosodium iodoacetate (MIA (show MIA Proteins)) was enhanced in mice lacking KOR (show OPRK1 Proteins) or PDYN gene. In contrast with the nociceptive manifestations induced by osteoarthritis, the increased microglial expression on the lumbar section of the spinal cord after MIA (show MIA Proteins) administration was similar in KOR (show OPRK1 Proteins)-KO, PDYN-KO and WT littermates. Moreover, anhedonic- and anxiolytic-like states were revealed after MIA (show MIA Proteins) administration.

  2. steroidal environment and energy state negatively regulate kisspeptin (Kiss1 (show KISS1 Proteins)), neurokinin B (Tac2), and dynorphin (Pdyn) gene expression.

  3. These pathways are consistent with previously reported behavioral and biochemical phenotypes that typify mice lacking ENT1 (show SLC29A1 Proteins). Moreover, we validated decreased expression of the SNARE (show VTI1B Proteins) complex protein VAMP1 (synaptobrevin-1 (show VAMP1 Proteins)) in the dHip as well as decreased expression of pro-dynorphin (PDYN), neuroendocrine convertase (PCSK1 (show PCSK1 Proteins)), and Leu-Enkephalin (dynorphin-A) in the nucleus accumbens

  4. DYN-A(2-17) interacts with Orexin A in the paraventricular hypothalamic nucleus to modulate food intake in mice.

  5. We found potential links between the alterations in expression of Tsc22d3 (show TSC22D3 Proteins), Nfkbia (show NFKBIA Proteins) and Pdyn, and different aspects of susceptibility to stress.

  6. This study identify that photostimulation of dyn-expressing cells in discrete subregions within the NAcSh drive opposing motivational behavioral states

  7. The results of this study indicated that PDYN have a differential role in cue-induced reinstatement of cocaine-seeking behavior.

  8. Double NPY (show NPY Proteins) and dynorphin deletion resulted in heavier mice, with increased adiposity, despite no significant changes in food intake or UCP-1 (show UCP1 Proteins) activity.

  9. These findings identify a unique cellular process by which orexin (show OX Proteins) can occlude the reward threshold-elevating effects of coreleased dynorphin and thereby act in a permissive fashion to facilitate reward.

  10. Data suggest that activation of neurokinin 3 and kappa-opioid receptors (NK3R (show TACR3 Proteins) and KOR (show OPRK1 Proteins)) excites and inhibits kisspeptin, neurokinin B (NKB), and dynorphin (KNDy neurons).

Cow (Bovine) Prodynorphin (PDYN) interaction partners

  1. The investigation of Dyn A 1-17 metabolism at the blood-brain barrier (BBB) is important since the metabolites exhibit unique biological functions compared to the parent compound.

Xenopus laevis Prodynorphin (PDYN) interaction partners

  1. The Xen-dorphin prohormone is a new opioid-like prohormone distinct from proenkephalin (show PENK Proteins) and prodynorphin.

Pig (Porcine) Prodynorphin (PDYN) interaction partners

  1. The expression of the genes coding for proopiomelanocortin (POMC (show POMC Proteins)), proenkephalin (PENK (show PENK Proteins)) and prodynorphin (PDYN) in porcine luteal cells isolated from corpora lutea (CL) collected on days 3-6, 8-10 and 13-16 of the oestrous cycle is reported.

Rhesus Monkey Prodynorphin (PDYN) interaction partners

  1. Influence of age and 17beta-estradiol on kisspeptin, neurokinin B, and prodynorphin gene expression in the arcuate-median eminence.

PDYN Protein Profile

Protein Summary

The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with Prodynorphin Proteins (PDYN)

  • prodynorphin (pdyn)
  • prodynorphin (PDYN)
  • prodynorphin (Pdyn)
  • prodynorphin L homeolog (pdyn.L)
  • prodynorphin S homeolog (pdyn.S)
  • ADCA protein
  • Dyn protein
  • olpa protein
  • olpb protein
  • PDYN protein
  • penkb protein
  • SCA23 protein
  • wu:fj38c03 protein
  • Xen-dorphin protein
  • XOLPA protein
  • XOLPB protein

Protein level used designations for Prodynorphin Proteins (PDYN)

Beta-neoendorphin-dynorphin , beta-neoendorphin-dynorphin , leu-enkephalin , leumorphin , neoendorphin-dynorphin-enkephalin prepropeptide , preprodynorphin , preproenkephalin B , proenkephalin-B , rimorphin , proenkephalin B , proenkephalin-B preproprotein , prodynorphin , dorphin A , dorphin B , fj38c03 , proenkephalin-b

GENE ID SPECIES
100195894 Salmo salar
5173 Homo sapiens
18610 Mus musculus
29190 Rattus norvegicus
281385 Bos taurus
403367 Xenopus laevis
403368 Xenopus laevis
414850 Danio rerio
445529 Sus scrofa
469860 Pan troglodytes
485808 Canis lupus familiaris
716341 Macaca mulatta
100135596 Cavia porcellus
100294654 Ovis aries
100341339 Oryctolagus cuniculus
100528666 Ictalurus punctatus
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