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PDCD2 encodes a nuclear protein expressed in a variety of tissues.
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PDCD2 and NCoR1 (show NCOR1 Proteins) may act as tumor suppressors in Gastrointestinal stromal tumors cells through the Smad (show SMAD1 Proteins) signaling pathway.
PDCD2 may play an important role in tumor suppression in osteosarcoma. These mechanisms might be related to immune response induced by CD4 (show CD4 Proteins)(+) and CD8 (show CD8A Proteins)(+) T cells.
Low PDCD2 expression is associated with gastric cancer.
Loss of PDCD2 expression could contribute to gastric cancer development and progression.
Expression of human PDCD2 fully rescues the Drosophila Zfrp8 phenotype, underlining the functional conservation of Zfrp8/PDCD2.
PDCD2 RNA expression in acute leukemia patients correlates with disease status and is a significant predictor of clinical relapse.
PDCD2 has a novel regulatory role in human hematopoiesis and is essential for erythroid development.
Transfection of a construct expressing PDCD2 induces apoptosis in human cell lines through activation of the caspase (show CASP3 Proteins) cascade.
To study the role of PDCD2_C domain in apoptosis, the cDNAs of two isoforms of PDCD2 and MGC13096 were cloned. PDCD2 (NM_002598) was over expressed when endothelial cells treated with leukotriene D4 or natural killer cells were activated by IL-2 (show IL2 Proteins).
repression of PDCD2 by BCL6 (show BCL6 Proteins) is likely important in the pathogenesis of certain human lymphomas
Pdcd2(-/-) embryos underwent implantation but did not undergo further development. Inner cell masses from Pdcd2(-/-) blastocysts failed to outgrow in vitro.
This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12.
programmed cell death 2
, programmed cell death 2 alternative transcript
, programmed cell death protein 2
, zinc finger MYND domain-containing protein 7
, zinc finger protein Rp-8