anti-Proline-Rich Transmembrane Protein 2 (PRRT2) Antibodies

PRRT2 encodes a transmembrane protein containing a proline-rich domain in its N-terminal half. Additionally we are shipping PRRT2 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PRRT2 112476 Q7Z6L0
PRRT2 69017  
PRRT2    
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Top anti-PRRT2 Antibodies at antibodies-online.com

Showing 10 out of 29 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, IHC (p) Western Blot: PRRT2 Antibody [NBP1-84168] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp.Lane 4: Human plasma (IgG/HSA depleted).Lane 5: Human liver tissue Immunohistochemistry-Paraffin: PRRT2 Antibody [NBP1-84168] - Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in cells in granular layer. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, IHC (p), WB Anti-PRRT2 antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated WB PRRT2 Antibody (Center)  western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the PRRT2 antibody detected the PRRT2 protein (arrow). Overlay histogram showing U-2 OS cells stained with ABIN2849225(green line). The cells were fixed with 2% paraformaldehyde (10 min) and then permeabilized with 90% methanol for 10 min. The cells were then icubated in 2% bovine serum albumin to block non-specific protein-protein interactions followed by the antibody (ABIN2849225, 1:25 dilution) for 60 min at 37ºC. The secondary antibody used was Goat-Anti-Rabbit IgG, DyLight® 488 Conjugated Highly Cross-Adsorbed(1583138) at 1/200 dilution for 40 min at 37ºC. Isotype control antibody (blue line) was rabbit IgG1 (1μg/1x10^6 cells) used under the same conditions. Acquisition of >10, 000 events was performed. Dilution: 1:25 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, WB Western blot analysis of PRRT2 in mouse brain tissue with PRRT2 polyclonal antibody  at 1 ug/mL. 100 μg Log in to see 11 to 12 Days
$356.00
Details
Human Rabbit Un-conjugated ELISA, IF, IHC (p), WB   0.1 mg Log in to see 2 to 3 Days
$360.00
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB   100 μg Log in to see 15 to 19 Days
$527.03
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 1 to 2 Days
$394.90
Details
Human Mouse Un-conjugated WB Western Blot analysis of PRRT2 expression in transfected 293T cell line by PRRT2 MaxPab polyclonal antibody.Lane 1: PRRT2 transfected lysate(37.4 KDa).Lane 2: Non-transfected lysate. 50 μg Log in to see 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated ELISA, WB   200 μL Log in to see 11 to 16 Days
$658.43
Details
Human Rabbit APC ELISA, WB   200 μL Log in to see 11 to 14 Days
$1,013.83
Details

More Antibodies against PRRT2 Interaction Partners

Human Proline-Rich Transmembrane Protein 2 (PRRT2) interaction partners

  1. Benign infantile epilepsy with PRRT2 mutation is characterized by early onset of seizure mostly before 6 months, focal seizures with or without secondary generalization, a high incidence of a cluster of seizures, rapid resolution of seizure by antiepileptic drugs and cessation of seizure mostly before 2 years of age; most PRRT2 gene mutations are heterozygous mutations, and a few are the overall deletion of PRRT2 gene

  2. This study identified a PRRT2 variant in a family with paroxysmal kinesigenic dyskinesia/benign familial infantile seizures and confirmed STX1B as a new binding partner of PRRT2, which suggested that the loss of the interaction between PRRT2 and STX1B may contribute to the pathogenesis of PKD/BFIS.

  3. Case Report: acute cerebellar ataxia associated with heterozygous PRRT2 mutation and transient cerebellar hyperintensity on diffusion MRI.

  4. This study showed that there is no significant difference in the the age at onset between the PKD patients with (n = 27) and without (n = 46) PRRT2 mutation.

  5. miR-30b promotes glioblastoma cell proliferation, migration, and invasion via targeting PRRT2.

  6. Results identified PRRT2 and DAB2IP to be frequently mutated in all different cancer cell line types. Further analysis showed that both genes were also frequently mutated in colorectal and endometrial cancer patient samples. Functional studies revealed PRRT2 to be implicated in cellular proliferation and migration with the truncated microsatellite instability-derived PRRT2 form promoting both processes.

  7. the expression level of PRRT2 was much higher in the human brain than in other human tissues, thus providing experimental evidence for a potential relationship between PRRT2 and neurogenesis. To the best of our knowledge, this study is the first to report the expression pattern of PRRT2 in human tissues.

  8. PRRT2 mutations have roles in neuronal dysfunction and neurodevelopmental defects

  9. The cases reported here constitute the first genetic-confirmed series of paroxysmal kinesigenic dyskinesia (PKD) in Hong Kong. The PRRT2 c.649dupC screening is recommened for all patients with all forms of PKD.

  10. Data show that proline-rich transmembrane protein 2 (PRRT2) is decreased in glioma and is targeted by microRNA miR-30a-5p.

  11. These findings indicate a novel role for zinc regulation in the PKCalpha/beta-catenin pathway and explain an important mechanism for controlling of stem cell program in lung cancer cells.

  12. PRRT2 mutations most likely not associated with benign epilepsy with centrotemporal spikes in Chinese mainland population.

  13. Exome sequencing was conducted and a duplication mutation c.649dupC (p.R217Pfs*8) in the proline-rich transmembrane protein 2 gene (PRRT2) was identified in patients with febrile seizures.

  14. In this study, 20 probands with BPEI were negative for family history of BPEI and negative for PRRT2 mutation.

  15. we found three new mutations in PRTTS in patients with Paroxysmal Kinesigenic Dyskinesia: c.insT27 p.Ser9*, c.G967A p.Gly323Arg and c.delCA215_216 p.Thr72Argfs*62.

  16. a novel intronic PRRT2 mutation causes paroxysmal kinesigenic dyskinesia with infantile convulsions

  17. comprehensive review of PRRT2-associated diseases.

  18. study highlights the frequency, novel mutations and clinical and molecular spectrum of PRRT2, SLC2A1 and PNKD mutations as well as the phenotype-genotype overlap among these paroxysmal movement disorders.

  19. 649dupC frameshift mutation of the PRRT2 gene is associated paroxysmal kinesigenic dyskinesia.

  20. mutant PRRT2, probably through its weakened interaction with SNAP25, affects glutamate signaling and glutamate receptor activity, resulting in the increase of glutamate release and subsequent neuronal hyperexcitability.

Mouse (Murine) Proline-Rich Transmembrane Protein 2 (PRRT2) interaction partners

  1. Study describes the phenotype of KO mice for PRRT2 and shows that its loss-of-function recapitulates the human phenotype in terms of episodic disturbances in motor coordination and paroxysmal dyskinesias, suggesting that PRRT2 plays a critical role in the development of cortical connectivity and functional stability of neuronal networks.

  2. PRRT2 mutations have roles in neuronal dysfunction and neurodevelopmental defects

  3. PRRT2 interacts with the Src homology 3 domain-bearing protein Intersectin 1, an intracellular protein involved in synaptic vesicle cycling.

  4. Mutants associated with paroxysmal kinesigenic dyskinesia with infantile convulsions C lead to dramatically reduced PRRT2 levels.

PRRT2 Antigen Profile

Protein Summary

This gene encodes a transmembrane protein containing a proline-rich domain in its N-terminal half. Studies in mice suggest that it is predominantly expressed in brain and spinal cord in embryonic and postnatal stages. Mutations in this gene are associated with episodic kinesigenic dyskinesia-1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PRRT2

  • proline rich transmembrane protein 2 (PRRT2) antibody
  • proline-rich transmembrane protein 2 (Prrt2) antibody
  • 1500031I19Rik antibody
  • AI195361 antibody
  • BFIC2 antibody
  • BFIS2 antibody
  • DSPB3 antibody
  • DYT10 antibody
  • EKD1 antibody
  • ICCA antibody
  • IFITMD1 antibody
  • PKC antibody

Protein level used designations for PRRT2

dispanin subfamily B member 3 , interferon induced transmembrane protein domain containing 1

GENE ID SPECIES
112476 Homo sapiens
69017 Mus musculus
100444066 Pongo abelii
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