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The protein encoded by PCSK7 belongs to the subtilisin-like proprotein convertase family. Additionally we are shipping Proprotein Convertase Subtilisin/kexin Type 7 Proteins (8) and many more products for this protein.
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SPC7 is required for normal development of the eye and brain, possibly through processing BMPs, though other potential substrates cannot be excluded.
PCSK7 is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.
Our present data suggest that PCSK7 as well as PCSK9 (show PCSK9 Antibodies) may be associated with lipids, especially triglyceride, and may serve as a candidate for a new drug target to treat lipid abnormality syndromes.
PCSK7 rs236918 C allele is a risk factor for cirrhosis development in Italian patients with HFE-Hemochromatosis (show HFE Antibodies).
Furin (show FURIN Antibodies) and PC7 siRNAs induced HIF-1alpha (show HIF1A Antibodies) protein by increasing its translation, resulting in upregulation of VEGF-A (show VEGFA Antibodies).
The data suggest that PCSK7 genotypes may interact with dietary CHO (show COL11A1 Antibodies) intake on changes in insulin (show INS Antibodies) sensitivity in the white Americans.
Results demonstrate that PCSK7 variation is a strong host risk factor of liver cirrhosis in hereditary hemochromatosis (show HFE Antibodies) patients homozygous for HFE (show HFE Antibodies) C282Y.
overexpression of PCs, furin (show FURIN Antibodies) and PC5 (show PCSK5 Antibodies), but not PC7, which are all expressed in SMC (show DYM Antibodies), increase PKGI (show PRKG1 Antibodies) cleavage in a dose-dependent manner
Among the PC family members, only furin (show FURIN Antibodies) activates hepcidin (show HAMP Antibodies) in hepatocytes, and uniquely the full-length membrane-bound PC7 can directly shed hTfR1 by cleavage at Arg100
PCSK7 is involved in sTfR (show TFRC Antibodies) generation and iron homeostasis.
Proprotein convertase PC7 enhances the activation of the EGF receptor (show EGFR Antibodies) pathway through processing of the EGF (show EGF Antibodies) precursor.
PC7 is distinct from other proprotein convertases in its zymogen activation, subcellular localization, and trafficking.
PC7 has a critical role in normal processing of cholecystokinin (show CCK Antibodies) in mouse brain
PC7 and the related proteases Furin (show FURIN Antibodies) and Pace4 (show PCSK6 Antibodies) regulate E-cadherin (show CDH1 Antibodies) function during blastocyst formation.
Data show that BDNF (show BDNF Antibodies) and PC7 mRNAs are colocalized in hippocampus and amygdala and that mature BDNF (show BDNF Antibodies) protein levels are reduced in these brain areas in proprotein convertase PC7 knockout mice.
in binding VEGFR-2 (show KDR Antibodies), furin (show FURIN Antibodies) and PC5 (show PCSK5 Antibodies) promote cleavage of N-and C-terminal VEGF-D (show Figf Antibodies) propeptides, whereas PC7 promotes cleavage of the C-terminal propeptide only
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease. It is structurally related to its family members, PACE and PACE4. This protein is concentrated in the trans-Golgi network, associated with the membranes, and is not secreted. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes. Multiple alternatively spliced transcripts are described for this gene but their full length nature is not yet known. Downstream of this gene's map location at 11q23-q24, nucleotides that match part of this gene's 3' end are duplicated and inverted. A translocation breakpoint associated with lymphoma occurs between this gene and its inverted counterpart.
proprotein convertase PC7
, proprotein convertase subtilisin/kexin type 7
, proprotein convertase subtilisin/kexin type 7-like
, lymphoma proprotein convertase
, prohormone convertase 7
, prohormone convertase PC7
, proprotein convertase 7
, proprotein convertase 8
, subtilisin/kexin-like protease PC7
, subtilisin-like proprotein convertase 7