anti-Prostaglandin E Receptor 4 (Subtype EP4) (PTGER4) Antibodies

The protein encoded by PTGER4 is a member of the G-protein coupled receptor family. Additionally we are shipping PTGER4 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PTGER4 5734 P35408
PTGER4 19219 P32240
PTGER4 84023 P43114
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Top anti-PTGER4 Antibodies at antibodies-online.com

Showing 10 out of 87 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated ELISA, WB ABIN185578 (0.1µg/ml) staining of Human Testes lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated WB Western blot analysis of PTGER4 using anti- PTGER4 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: SW620 whole Cell lysates,   Lane 2: MCF-7 whole cell lysates.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti- PTGER4 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for PTGER4 at approximately 53KD. The expected band size for PTGER4 is at 53KD. 100 μg Log in to see 4 to 6 Days
$240.00
Details
Bat Rabbit Un-conjugated ICC, IHC, IHC (p) 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ICC, IHC, IHC (p) 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ICC, IHC, IHC (p) 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of EP4 expression in Ramos (A), HeLa (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from COLO205 cells, using PE2R4 Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of MCF7 cells, using PE2R4 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, IF, WB Western Blot (WB) analysis of specific cells using EP4 Polyclonal Antibody. 100 μL Log in to see Available
$363.46
Details
Human Rabbit Un-conjugated ICC, IHC, IHC (p) Anti-PTGER4 / EP4 antibody  ABIN1049261 IHC staining of human colon, ganglion. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-PTGER4 / EP4 antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Cow Rabbit Un-conjugated IHC, IHC (p) Anti-PTGER4 / EP4 antibody  ABIN1049259 IHC staining of human colon, ganglion. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-PTGER4 / EP4 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details

Top referenced anti-PTGER4 Antibodies

  1. Human Polyclonal PTGER4 Primary Antibody for WB - ABIN1881704 : Bastien, Sawyer, Grygorczyk, Metters, Adam: Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype. in The Journal of biological chemistry 1994 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal PTGER4 Primary Antibody for ELISA, WB - ABIN251245 : Parida, Parekh, Dey, Ghosh, Mandal: Molecular inhibition of prostaglandin E2 with GW627368X: Therapeutic potential and preclinical safety assessment in mouse sarcoma model. in Cancer biology & therapy 2015 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal PTGER4 Primary Antibody for ICC, IF - ABIN4348399 : Prijatelj, Celhar, Mlinaric-Rascan: Prostaglandin EP4 receptor enhances BCR-induced apoptosis of immature B cells. in Prostaglandins & other lipid mediators 2011 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal PTGER4 Primary Antibody for IHC, IHC (p) - ABIN4348401 : Oll, Baumann, Behbahani, von Ruecker, Müller, Ellinger: Identification of prostaglandin receptors in human ureters. in BMC urology 2013 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal PTGER4 Primary Antibody for WB - ABIN519449 : Xiao, Li, Jones-Brando, Yolken: Abnormalities of neurotransmitter and neuropeptide systems in human neuroepithelioma cells infected by three Toxoplasma strains. in Journal of neural transmission (Vienna, Austria : 1996) 2013 (PubMed)

  6. Dog (Canine) Polyclonal PTGER4 Primary Antibody for ELISA, WB - ABIN547619 : Echeverria, Clerman, Doré: Stimulation of PGE receptors EP2 and EP4 protects cultured neurons against oxidative stress and cell death following beta-amyloid exposure. in The European journal of neuroscience 2005 (PubMed)

More Antibodies against PTGER4 Interaction Partners

Zebrafish Prostaglandin E Receptor 4 (Subtype EP4) (PTGER4) interaction partners

  1. Lkt/ABCC4-mediated PGE2 signalling acts through a ciliary G-protein-coupled receptor, EP4, to upregulate cAMP synthesis and increase anterograde intraflagellar transport, thereby promoting ciliogenesis.

  2. Ep4a, a PGE2 receptor isoform of EP4, is involved in lymphoid precursor development in zebrafish.

Human Prostaglandin E Receptor 4 (Subtype EP4) (PTGER4) interaction partners

  1. Data indicates that PGE2 suppression of TNF-alpha by human monocytic cells occurs via EP2R and EP4R expression. However EP4Rs also control their own expression and that of EP2 whereas the EP2R does not affect EP4R expression. This implies that EP4 receptors have an important master role in controlling inflammatory responses.

  2. discovery of recurrent PTGER4 amplification implies a potential of exploring targeting therapy to the prostaglandin synthesis pathways in a subset of these tumors

  3. High EP4 expression is associated with chemoresistant breast carcinoma.

  4. Study demonstrated that the expression of EP4 receptors was up-regulated by c-Myc by binding to Sp-1 under low cellular density conditions but was down-regulated under high cellular density conditions via the increase in the expression levels of HIF-1alpha protein, which may pull out c-Myc and Sp-1 from DNA-binding.

  5. results indicate that PGE2 inhibits hCAP18/LL-37 expression, especially VD3-induced cathelicidin and autophagy, which may reduce host defense against Mtb. Accordingly, antagonists of EP4 may constitute a novel adjunctive therapy in Mtb infection.

  6. Case Report: elevated EP4 expression in pulmonary hypertension patient with dissecting pulmonary aneurysm.

  7. Collectively, these results indicate that COX-1/PGE2/EP4 upregulates the beta-arr1 mediated Akt signaling pathway to provide mucosal protection in colitis.

  8. Reprogramming of mammary epithelial cells can result from EP4 -mediated stem cell property transfer by extracellular vesicles/exosomes containing caveolae-associated proteins, between mammary basal and luminal epithelial cells.

  9. High PTGER4 methylation is associated with Lung cancer.

  10. in breast cancer cells overexpression of S1P3 and its activation by S1P has pro-inflammatory and pro-metastatic potential by inducing COX-2 expression and PGE2 signaling via EP2 and EP4.

  11. These results indicate that the blockage of PGE2-EP4 signaling prevents the bone destruction required for prostate cancer metastases, and that this is, in part due to the abrogation of bone cell responses. The study provides further evidence that an EP4 antagonist is a candidate for the treatment of prostate cancer in the blockade of bone metastasis.

  12. The results show that stimulation with the selective EP4 agonist CAY10598 or PGE2 promotes invadopodia-mediated degradation of the ECM, as well as the invasion of breast cancer cells in in vitro models.

  13. EP4 expression can promote the development of resistance to aromatase inhibitor therapy for breast cancer

  14. Findings suggest SUMO-1 protein and PGE2 receptor subtype 4 (EP4) as two potential targets for new therapeutic or prevention strategies for endometrial cancers.

  15. GW627368X therefore effectively inhibits cervical cancer survival, motility, proliferation and angiogenesis by blocking EP4/EGFR interactive signaling.

  16. The cross-talk between SP1 and p65, and the positive feedback regulatory loop of PI3-K/Akt signaling by EP4 contribute to the overall responses of solamargine in this process

  17. The PTGER4 gene is a candidate risk factor for radiological progression in rheumatoid arthritis

  18. IP and EP4 receptors have a role in prostanoid regulation of angiogeneis

  19. miRNA 526b is a COX-2 upregulated, oncogenic miRNA promoting stem-like cells, the expression of which follows EP4 receptor-mediated signaling.

  20. Altered inhibitory function of the EP4R in eosinophils and monocytes from aspirin-intolerant patients

Mouse (Murine) Prostaglandin E Receptor 4 (Subtype EP4) (PTGER4) interaction partners

  1. Overexpression of EP4 improves cardiac function post myocardial infarction.

  2. Study reports that mPGES-1 protects against acute myocardial ischemia-reperfusion (I/R) injury in mice and this is attributed to its critical role in preserving microcirculation and limiting inflammation in I/R. The cardioprotective effect of mPGES-1 is partially mediated through PGE2 action on the endothelial PGE receptor-4.

  3. Our data suggest that deletion of EP4 in S100a4-lineage cells inhibits range of motion-limiting scar tissue without further compromising mechanical properties.

  4. EP4 enhancement aggravated imbalanced mesangial cell proliferation stimulated by TGFbeta1 and GS of mice treated with 5/6 nephrectomy through the Smad and mitogenactivated protein kinase pathways.

  5. EP4 is a novel regulator of bile acid synthesis, and its activation protects against hypercholesterolemia.

  6. Paricalcitol also attenuated the infiltration of inflammatory cells and production of proinflammatory cytokines after IR injury. EP4 antagonist abolished these antioxidant, anti-inflammatory, and antiapoptotic effects. The EP4 plays a pivotal role in the protective effects of paricalcitol in renal IR injury.

  7. These results demonstrate a novel role for prostaglandin receptor EP4 in the mediation of barrier-enhancing and anti-inflammatory effects caused by oxidized phospholipids.

  8. The deletion of EP4 increases mitochondrial biogenesis and oxidative capacity in WAT, and fat mass loss ensues in mice.

  9. Myeloid cell Ptger4 modulates interleukin production but not atherogenesis in type I diabetic mice.

  10. These data suggest that vascular EP4 receptors buffer the actions of AngII on renal hemodynamics and oxidative injury.

  11. the roles of prostaglandin E2 (PGE2) receptor (EP) signaling in enhancement of lymphangiogenesis in wound healing processes

  12. these studies have demonstrated an important but unexpected role for macrophage COX-2/prostaglandin E2/PGE2 receptor subtype 4 signaling to lessen progression of diabetic kidney disease, unlike the pathogenic effects of increased COX-2 expression in intrinsic renal cells.

  13. data demonstrate that endogenous PGE2, EP2 receptors, and EPAC are prerequisites for maximal LPS-induced IL-33 expression and that exogenous PGE2 can amplify IL-33 production via EP2 and EP4 receptors.

  14. The data presented highlight a key role for EP2 and EP4 receptors in microvascular leak induced by PGE2.

  15. It mediates neuritogenesis in sensory neuron.

  16. These results suggest that Il23a expression in DCs is synergistically triggered by the PG E2-EP4-cAMP-PKA pathway and canonical/non-canonical NF-kappaB pathways and CREB activated by CD40 stimulation.

  17. autocrine prostaglandin E2 signaling through EP receptors is essential for optimal CD4(+) T-cell activation.

  18. PGE2-mediated EP4 signaling in myeloid cells promotes tumorigenesis.

  19. the blockade of EP2 and EP4 promotes mouse survival after cryptococcus infection by promoting the production of cytokines via TLR4, as well as the enhanced M1 polarization of alveolar macrophages

  20. the lean phenotype of EP4-deficient mice resulted from reduction in adipose tissue and accretion of other peripheral organs caused by impaired triglyceride clearance

Cow (Bovine) Prostaglandin E Receptor 4 (Subtype EP4) (PTGER4) interaction partners

  1. Data suggest that lysophosphatidic acid (LPA) up-regulates expression of SLCO2A1 (prostaglandin [PG] transporter), PTGER2/PTGER4 (PG receptors EP2/EP4), and mPGES1/cPGES (microsomal/cytosolic PG E synthases) in luteal cells.

  2. Data suggest that estradiol up-regulates mRNA and protein expression of 3 prostanoid receptors in oviduct smooth muscle: EP2/PTGER2 (prostaglandin E receptor 2); EP4/PTGER4 (prostaglandin E receptor 4); and FP/PTGFR (prostaglandin F2alpha receptor).

  3. The PGE2-mediated down-regulation of CD25 expression on T cells is mediated via the EP4 receptor, although selective activation of the EP2 receptor up-regulates the CD25 expression on these cells.

  4. EP4 is undetectable in endometrium and myometrium during the estrous cycle

  5. Quantitative RT-PCR revealed significant higher expression of EP2 and EP4 in the pre-ovulatory phase compared with the luteal phase in the bovine oviduct

PTGER4 Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.

Gene names and symbols associated with PTGER4

  • prostaglandin E receptor 4 (PTGER4) antibody
  • prostaglandin E receptor 4 (subtype EP4) (PTGER4) antibody
  • prostaglandin E receptor 4 (subtype EP4) a (ptger4a) antibody
  • prostaglandin E receptor 4 (ptger4) antibody
  • prostaglandin E receptor 4 subtype EP4 (ptger4) antibody
  • prostaglandin E receptor 4 (subtype EP4) (Ptger4) antibody
  • prostaglandin E receptor 4 (Ptger4) antibody
  • ep4 antibody
  • EP4R antibody
  • PGE2R-EP4 antibody
  • Ptger antibody
  • PTGER4 antibody
  • ptger4l antibody
  • Ptgerep4 antibody

Protein level used designations for PTGER4

prostaglandin E receptor 4, subtype EP4 , prostaglandin E2 receptor EP4 subtype , prostaglandin E2 receptor subtype 4 , prostaglandin E receptor 4 (subtype EP4) , ep4 , ep4a , prostaglandin E receptor 4 , prostaglandin E receptor 4 subtype EP4 , PGE receptor EP4 subtype , PGE receptor, EP4 subtype , PGE2 receptor EP4 subtype , prostanoid EP4 receptor , prostaglandin E receptor 4 (EP4 subtype) , prostaglandin E receptor EP4 subtype , prostaglandin E2 receptor type 4 , PGE receptor, subtype EP4 , prostaglandin receptor EP4 subtype , prostaglandin E2 subtype EP4 receptor

GENE ID SPECIES
427183 Gallus gallus
443222 Ovis aries
562469 Danio rerio
695220 Macaca mulatta
100145708 Xenopus (Silurana) tropicalis
100169968 Felis catus
100510774 Anolis carolinensis
5734 Homo sapiens
19219 Mus musculus
84023 Rattus norvegicus
403589 Canis lupus familiaris
282331 Bos taurus
100009081 Oryctolagus cuniculus
450195 Pan troglodytes
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