Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Predicted Reactivity
B, Rb, Rat
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This PTGER4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242-269 amino acids from the Central region of human PTGER4.
PTGER4
Reactivity: Human
WB, ELISA, IF
Host: Rabbit
Polyclonal
unconjugated
Application Notes
WB: 1:1000. IHC-P: 1:25
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Mori, Tanaka, Kotani, Miyaoka, Sando, Muro, Sasaki, Nakagawa, Ogawa, Usui, Ozaki, Ichikawa, Narumiya, Nakao: "Gene expression of the human prostaglandin E receptor EP4 subtype: differential regulation in monocytoid and lymphoid lineage cells by phorbol ester." in: Journal of molecular medicine (Berlin, Germany), Vol. 74, Issue 6, pp. 333-6, (1996) (PubMed).
Foord, Marks, Stolz, Bufflier, Fraser, Lee: "The structure of the prostaglandin EP4 receptor gene and related pseudogenes." in: Genomics, Vol. 35, Issue 1, pp. 182-8, (1996) (PubMed).
Bastien, Sawyer, Grygorczyk, Metters, Adam: "Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype." in: The Journal of biological chemistry, Vol. 269, Issue 16, pp. 11873-7, (1994) (PubMed).
An, Yang, Xia, Goetzl: "Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2." in: Biochemical and biophysical research communications, Vol. 197, Issue 1, pp. 263-70, (1994) (PubMed).
Target
PTGER4
(Prostaglandin E Receptor 4 (Subtype EP4) (PTGER4))
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.