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anti-Protease, serine, 12 (Neurotrypsin, Motopsin) (PRSS12) Antibodies

PRSS12 encodes a member of the trypsin family of serine proteases. Additionally we are shipping Protease, serine, 12 (Neurotrypsin, Motopsin) Kits (23) and Protease, serine, 12 (Neurotrypsin, Motopsin) Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PRSS12 8492 P56730
PRSS12 19142 O08762
PRSS12 85266 G3V801
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Top anti-Protease, serine, 12 (Neurotrypsin, Motopsin) Antibodies at antibodies-online.com

Showing 10 out of 32 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Human Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg 11 to 14 Days
$616.00
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg 6 to 8 Days
$495.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB   0.1 mg 4 to 8 Days
$522.50
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Used in DAB staining on fromalin fixed paraffin-embedded Brain tissue 100 μg 13 to 16 Days
$342.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μg 15 to 19 Days
$527.03
Details
Human Mouse Un-conjugated ELISA, WB   100 μg 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg 12 to 14 Days
$686.14
Details
Human Mouse Un-conjugated WB Western Blot analysis of PRSS12 expression in transfected 293T cell line by PRSS12 MaxPab polyclonal antibody.Lane 1: PRSS12 transfected lysate(55.55 KDa).Lane 2: Non-transfected lysate. 50 μL 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated IF, IHC (p) Immunofluorescent staining of U-2 OS with PRSS12 polyclonal antibody (Green) shows localization to actin filaments. Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cerebral cortex with PRSS12 polyclonal antibody shows moderate cytoplasmic positivity in neuronal cells. 100 μL 11 to 12 Days
$637.32
Details
Human Rabbit Un-conjugated ELISA, FM, IHC, WB Immunofluorescence of Neurotrypsin Antibody Immunofluorescence Microscopy of Neurotrypsin antibody. Tissue: Human brain cells. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: Neurotrypsin antibody at 20 µg/mL for 1 h at RT. Secondary antibody: Fluorescein rabbit secondary antibody at 1:10,000 for 45 min at RT. Staining: Neurotrypsin as red fluorescent signal. Western Blot of Neurotrypsin Antibody Western Blot of Neurotrypsin antibody.   Lane A:  SK-N-SH cell lysate at 0.5 µg/mL.   Lane B:  SK-N-SH cell lysate at 1 µg/mL.               Lane C:  SK-N-SH cell lysate at 2 µg/mL. Load:  35 µg per lane. Secondary antibody:   Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Block:  5% BLOTTO overnight at 4°C. Predicted/Observed size:  97 kDa, ~53 & ~116 kDa for Neurotrypsin. Other band(s): Neurotrypsin splice variants and isoforms. 100 μg 1 to 2 Days
$394.90
Details

Top referenced anti-Protease, serine, 12 (Neurotrypsin, Motopsin) Antibodies

  1. Human Polyclonal PRSS12 Primary Antibody for IHC (p), WB - ABIN541302 : Gschwend, Krueger, Kozlov, Wolfer, Sonderegger: Neurotrypsin, a novel multidomain serine protease expressed in the nervous system. in Molecular and cellular neurosciences 1997 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal PRSS12 Primary Antibody for IHC, ELISA - ABIN1002901 : Mitsui, Yamaguchi, Osako, Yuri: Enzymatic properties and localization of motopsin (PRSS12), a protease whose absence causes mental retardation. in Brain research 2007 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Protease, serine, 12 (Neurotrypsin, Motopsin) Interaction Partners

Human Protease, serine, 12 (Neurotrypsin, Motopsin) (PRSS12) interaction partners

  1. 4-base pair deletion in the neurotrypsin gene was associated with autosomal recessive nonsyndromic mental retardation; findings suggest that neurotrypsin-mediated proteolysis is required for normal synaptic function

Mouse (Murine) Protease, serine, 12 (Neurotrypsin, Motopsin) (PRSS12) interaction partners

  1. This study identifies Tequila and neurotrypsin as new genes repressed by presenilins and reveals a novel mechanism used by presenilins to modulate CREB signaling based on controlling CREB recruitment.

  2. co-expression of sez-6 with motopsin restored the effect of motopsin at the basal level, while sez-6 expression alone showed no effects on cell morphology. Our results suggest that the interaction of motopsin and sez-6 modulates neuronal cell morphology

  3. Our results indicate that an extracellular protease, motopsin, preferentially affects social behaviors, and modulates the functions of hippocampal neurons.

  4. motopsin has multiple functions, such as axon outgrowth, arranging perineuronal environment, and maintaining neuronal plasticity, partly in coordination with other proteases including tissue plasminogen activator.

  5. neurotrypsin exclusively cleaves glycanated variants of agrin; neurotrypsin-dependent cleavage of agrin was concentrated at synapses, where the most heavily glycanated variants of agrin predominate

  6. Detailed analyses indicated that presynaptic action potential firing is necessary for the release of neurotrypsin, whereas postsynaptic NMDA receptor activation is necessary for the neurotrypsin-dependent cleavage of agrin.

Protease, serine, 12 (Neurotrypsin, Motopsin) (PRSS12) Antigen Profile

Protein Summary

This gene encodes a member of the trypsin family of serine proteases. Studies in mouse suggest that the encoded enzyme may be involved in structural reorganizations associated with learning and memory. The enzyme is also expressed in Leydig cells in the testis, but its function in this tissue is unknown. Defects in this gene are a cause of mental retardation autosomal recessive type 1 (MRT1).

Gene names and symbols associated with PRSS12

  • protease, serine 12 (PRSS12) antibody
  • 26S proteasome regulatory SU (prsS12) antibody
  • prsS12 (HAN_3g451) antibody
  • neurotrypsin (CpipJ_CPIJ005457) antibody
  • neurotrypsin (CpipJ_CPIJ005852) antibody
  • protease, serine 12 neurotrypsin (motopsin) (Prss12) antibody
  • protease, serine 12 (Prss12) antibody
  • Bssp-3 antibody
  • BSSP3 antibody
  • motopsin antibody
  • MRT1 antibody
  • Nt antibody
  • PRSS12 antibody

Protein level used designations for PRSS12

protease, serine, 12 (neurotrypsin, motopsin) , 26S proteasome regulatory SU , prsS12 , neurotrypsin , brain-specific serine protease 3 , leydin , serine protease 12 , peptidase, serine, 12 (neurotrypsin, motopsin)

GENE ID SPECIES
422685 Gallus gallus
512034 Bos taurus
857479 Guillardia theta
5739504 Hemiselmis andersenii
6037525 Culex quinquefasciatus
6037801 Culex quinquefasciatus
10447290 Cryptomonas paramecium
100353449 Oryctolagus cuniculus
100524882 Sus scrofa
8492 Homo sapiens
704461 Macaca mulatta
471291 Pan troglodytes
19142 Mus musculus
85266 Rattus norvegicus
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