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PRSS3 encodes a trypsinogen, which is a member of the trypsin family of serine proteases.
Showing 9 out of 11 products:
PRSS3 is downregulated by intragenic hypermethylation in HCC (show FAM126A Proteins). * Epigenetic silencing of PRSS3 facilitates growth, migration, and invasion of HCC (show FAM126A Proteins). * PRSS3 intragenic methylation has implication in diagnosis of HCC (show FAM126A Proteins).
PRSS3 acts as an oncogene (show RAB1A Proteins) in invasive ductal carcinoma of the breast development and progression
Study developed a new high resolution crystal structure of mesotrypsin complexed with diminazene through a structure-based molecular docking screen that could help facilitate derivatization efforts, addressing current pan-inhibition of human trypsins through rigidification of diminazene to select for a conformation that maximizes interactions with the non-conserved Arg-193 residue.
Data show that silencing tumor-endothelial cells (EC) for trypsinogen 4 accumulated tissue factor pathway inhibitor-2 (TFPI-2 (show TFPI2 Proteins)) in the matrix.
These findings suggest that inhibitor cleavage represents a functional adaptation of mesotrypsin that may have evolved in response to positive selection pressure.
High PRSS3 expression in EOC tissues was significantly associated with advanced FIGO stage and lymph node metastasis.
Data suggest that mesotrypsin cleavage of Kunitz domains may contribute to cancer progression.
Mesotrypsin generated saposins A-D from prosaposin (show PSAP Proteins), and mature caspase-14 (show CASP14 Proteins) contributed to this process by activating mesotrypsinogen to mesotrypsin. Knockdown of these proteases markedly down-regulated saposin A synthesis in skin equivalent models.
extra-pancreatic trypsinogen 3 is produced by esophageal adenocarcinoma cells and activates PAR-2 (show F2RL1 Proteins) in an autocrine manner.
IFN regulatory factor 2 (Irf2 (show IRF2 Proteins)) has a regulatory role in trypsinogen5 gene transcription, which is resistant to a major endogenous trypsin inhibitor, Spink3 (show SPINK1 Proteins)
Intra-acinar activation of trypsinogen is sufficient to initiate acute pancreatitis.
the initiation of acute pancreatitis depends on endocytic vacuole formation and trypsinogen activation in pancreatic acinar cells
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene.
, brain trypsinogen
, pancreatic trypsinogen III
, protease, serine, 4 (trypsin 4, brain)
, trypsin III
, trypsin IV
, trypsinogen 4
, trypsinogen 5
, trypsinogen IV
, trypsin 3
, trypsinogen 15
, cationic trypsin III
, cationic trypsin-3
, cationic trypsinogen
, pretrypsinogen III