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MLLT10 encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Additionally we are shipping MLLT10 Proteins (3) and MLLT10 Kits (1) and many more products for this protein.
Showing 10 out of 130 products:
Human Polyclonal MLLT10 Primary Antibody for IF, WB - ABIN1882102
Cai, Gao, Sheng, Miao, Cui, Wang, Zong, Koide: Characterization and potential function of a novel testis-specific nucleoporin BS-63. in Molecular reproduction and development 2002
Show all 6 Pubmed References
Rat (Rattus) Polyclonal MLLT10 Primary Antibody for ELISA, WB - ABIN4278553
Lin, Kakadia, Chen, Li, Deshpande, Buske, Zhang, Zhang, Xu, Bohlander: Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10-positive leukemias. in Blood 2009
In a retroviral transduction/transplantation mouse model, mice transplanted with MLL (show MLL Antibodies)/AF10(OM-LZ) cells harboring PTPN11 (show PTPN11 Antibodies)(wt) developed myelomonocytic leukemia. Those transplanted with cells harboring PTPN11 (show PTPN11 Antibodies)(G503A) -induced monocytic leukemia (show KAT6B Antibodies) in a shorter latency. Adding PTPN11 (show PTPN11 Antibodies)(G503A) to MLL (show MLL Antibodies)/AF10 affected cell proliferation, chemo-resistance, differentiation, in vivo BM recruitment/clonal expansion and faster progression.
Our results provide evidence for new loci influencing abdominal visceral (BBS9 (show BBS9 Antibodies), ADCY8 (show ADCY8 Antibodies), KCNK9 (show KCNK9 Antibodies)) and subcutaneous (MLLT10/DNAJC1 (show DNAJC1 Antibodies)/EBLN1 (show EBLN2 Antibodies)) fat, and confirmed a locus (THNSL2 (show THNSL2 Antibodies)) previously reported to be associated with abdominal fat in women
The PZP (show PZP Antibodies) domain of AF10 senses unmodified H3K27 to regulate DOT1L (show DOT1L Antibodies)-mediated methylation of H3K79.
we report that variants at the MLLT10 locus are unlikely to alter risk of glioma, and they have no prognostic value among patients with high-grade tumors (glioblastoma).
Results provide evidence that transformation driven by MLL (show MLL Antibodies) fusions as well as the recurrent AML (show RUNX1 Antibodies)-associated NUP98 (show NUP98 Antibodies)-NSD1 (show NSD1 Antibodies) fusion oncogene (show RAB1A Antibodies) is critically dependent on the ability of AF10 to stimulate DOT1L (show DOT1L Antibodies) activity.
detection of PICALM (show PICALM Antibodies)-MLLT10 fusion transcript occurs in 7% of children with T-lineage ALL and is not associated with a poorer outcome for patients treated with contemporary, intensive chemotherapy
In pediatric T-acute lymphoblastic leukemia, we have identified 2 RNA processing genes, that is, HNRNPH1 (show HNRNPH1 Antibodies)/5q35 and DDX3X (show DDX3X Antibodies)/Xp11.3 as new MLLT10 fusion partners.
results strongly indicate that the differential regulation of these three genes is not due to the break point effect but as a consequence of the CALM/AF10 fusion gene expression, though the mechanism of regulation is not well understood
In leukemia cells, full-length CALM-AF10 localized to the nucleus with no consistent effect on growth factor endocyctosis, and suppressed histone H3 lysine 79 methylation regardless of the presence of clathrin
a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 x 10(-14)) was identified.
During leukemogenesis, CALM-AF10 plays critical roles in the cytoplasm.
further suggest that future approaches to antagonize CALM-AF10-induced transformation should incorporate strategies, which aim at blocking these key domains
conclude that Mllt10/Af10-Dot1l (show DOT1L Antibodies) are essential, largely dedicated activators of Wnt (show WNT2 Antibodies)-dependent transcription, critical for maintenance of intestinal proliferation and homeostasis
This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene.
ALL1-fused gene from chromosome 10 protein
, protein AF-10
, type I AF10 protein
, type III AF10 protein
, type IV AF10 protein
, myeloid/lymphoid or mixed lineage-leukemia translocation to 10 homolog