Protein Interacting With Protein Kinase C, alpha 1 Proteins (PICK1)

Human Protein Interacting With Protein Kinase C, alpha 1 (PICK1) interaction partners

1. PICK1 is a cargo-specific endocytic accessory protein required for efficient, activity-dependent AMPAR endocytosis.

2. Our results demonstrate that downregulation of PICK1 elicited by miR (show MLXIP Proteins)-210-3p overexpression activates the TGF-b pathway, which further promotes bone metastasis in PCa (show FLVCR1 Proteins), indicating that the miR (show MLXIP Proteins)- 210-3p/PICK1/TGF-b signalling axis plays an important role in PCa (show FLVCR1 Proteins) bone metastasis.

3. This study defines a novel mechanism whereby elevated [Ca(2 (show CA2 Proteins)+)] induced by NMDA receptor activation modulates Ago2 (show EIF2C2 Proteins) and miRNA activity via PICK1. Our work suggests a Ca(2 (show CA2 Proteins)+)-dependent process to regulate miRNA activity in neurons in response to the induction of long-term depression.

4. We propose that PICK1 negatively regulates neoplastic infiltration of astrocytic tumors and that manipulation of PICK1 is an attractive possibility for therapeutic intervention

5. PICK1 domain ACT links PICK1-associated vesicles to a motility factor, likely myosin, but, contrary to previous reports, PICK1 neither binds nor inhibits Arp2 (show ACTR2 Proteins)/3 complex.

6. Unlike accessory domains in other BAR domain proteins, the positioning of the PDZ domains is flexible, enabling PICK1 to perform long-range, dynamic scaffolding of membrane-associated proteins.

7. Data indicate three principal binding modes can account for protein interacting with C-kinase 1 (PICK1) PDZ domains binding specificity.

8. PICK1 promotes Ago2 (show EIF2C2 Proteins) localization at endosomal compartments in neuronal dendrites and inhibits Ago2 (show EIF2C2 Proteins) function in translational repression following neuronal stimulation.

9. These data indicate that Pick1 is involved in regulating the cell-cell junction in epithelial cells.

10. C-terminal domain of ICA69 (show ICA1 Proteins) interacts with PICK1 and acts on trafficking of PICK1-PKCalpha (show PKCa Proteins) complex and cerebellar plasticity.

Mouse (Murine) Protein Interacting With Protein Kinase C, alpha 1 (PICK1) interaction partners

1. the results indicate that PICK1 is a potent inhibitor of Parkin (show PARK2 Proteins), and the reduction of PICK1 enhances the protective effect of Parkin (show PARK2 Proteins).

2. PICK1 regulates glutamateinduced exocytosis in beta cells.

3. These results suggest that the PDZ domain of PICK1 directly interacts with calcineurin B in osteoclast progenitor cells and promotes osteoclast differentiation through activation of calcineurin-NFAT (show NFATC1 Proteins) signaling.

4. we summarize recent advances focusing on the structure and regulation of PICK1 and its functions in protein trafficking, neurological and non-neurological--{REVIEW}

5. Ca(2 (show CA2 Proteins)+) influx through ASIC1 (show ACCN2 Proteins) mediates chronic hypoxia and ET-1 (show EDN1 Proteins)-induced NFATc3 (show NFATC3 Proteins) nuclear import and 2) the scaffolding protein PICK1 is necessary for NFATc3 (show NFATC3 Proteins) nuclear import.

6. a dual role of PICK1 in regulating macrophage polarization

7. This study demonstrated that d-serine provent the behavioral deficits in adult Pick1 knockout mice.

8. PICK1 is an important regulator of P2Y6R (show P2RY6 Proteins) expression and microglial phagocytosis.

9. knocking-out PICK1 gene casts the neuroprotection effect by reducing ASICs current and the calcium transients in OGD (show FGFR1 Proteins)-Rep neuronal cells

10. ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis.