Protein Interacting With Protein Kinase C, alpha 1 Proteins (PICK1)

The protein encoded by PICK1 contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). Additionally we are shipping PICK1 Antibodies (147) and PICK1 Kits (37) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PICK1 9463 Q9NRD5
PICK1 18693  
PICK1 84591 Q9EP80
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Top PICK1 Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$736.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$888.80
Details
Escherichia coli (E. coli) Human GST tag 100 μg Log in to see 11 Days
$411.40
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Cynomolgus His tag   1 mg Log in to see 60 to 71 Days
$3,153.33
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,157.00
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$3,160.67
Details
Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
Details

PICK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for Protein Interacting With Protein Kinase C, alpha 1 (PICK1) Interaction Partners

Human Protein Interacting With Protein Kinase C, alpha 1 (PICK1) interaction partners

  1. this is the first study to indicate that PICK1 polymorphisms may associate with cognitive functions in schizophrenic patients.

  2. Coincident with the loss of PICK1 by GBF1-activated ARF1, CDC42 recruitment leads to the activation of IRSp53 and the ARP2/3 complex, resulting in a burst of F-actin polymerisation potentially powering scission.

  3. PICK1 is a cargo-specific endocytic accessory protein required for efficient, activity-dependent AMPAR endocytosis.

  4. Our results demonstrate that downregulation of PICK1 elicited by miR-210-3p overexpression activates the TGF-b pathway, which further promotes bone metastasis in PCa, indicating that the miR- 210-3p/PICK1/TGF-b signalling axis plays an important role in PCa bone metastasis.

  5. This study defines a novel mechanism whereby elevated [Ca(2+)] induced by NMDA receptor activation modulates Ago2 and miRNA activity via PICK1. Our work suggests a Ca(2+)-dependent process to regulate miRNA activity in neurons in response to the induction of long-term depression.

  6. We propose that PICK1 negatively regulates neoplastic infiltration of astrocytic tumors and that manipulation of PICK1 is an attractive possibility for therapeutic intervention

  7. PICK1 domain ACT links PICK1-associated vesicles to a motility factor, likely myosin, but, contrary to previous reports, PICK1 neither binds nor inhibits Arp2/3 complex.

  8. Unlike accessory domains in other BAR domain proteins, the positioning of the PDZ domains is flexible, enabling PICK1 to perform long-range, dynamic scaffolding of membrane-associated proteins.

  9. Data indicate three principal binding modes can account for protein interacting with C-kinase 1 (PICK1) PDZ domains binding specificity.

  10. PICK1 promotes Ago2 localization at endosomal compartments in neuronal dendrites and inhibits Ago2 function in translational repression following neuronal stimulation.

  11. These data indicate that Pick1 is involved in regulating the cell-cell junction in epithelial cells.

  12. C-terminal domain of ICA69 interacts with PICK1 and acts on trafficking of PICK1-PKCalpha complex and cerebellar plasticity.

  13. Family-based association study failed to observe a statistically significant association for any of the genotyped SNPs in the PICK1 gene and attention-deficit hyperactivity disorder.

  14. PICK1 increases caveolin-mediated endocytosis, ubiquitination and degradation of TGF-beta type I receptor.

  15. The binding affinities of all major PICK1 interacting proteins are reported and the effects of PICK1 mutations on these interactions are described.

  16. Our data suggest a selective role of PICK1 in clustering and reducing the recycling rates of PDZ domain binding partners sorted to the Rab11-dependent recycling pathway.

  17. PICK1 is a suppressor of spinocerebellar ataxia 3-associated neurodegeneration.

  18. Neph proteins and PICK1 synergistically regulate cell recognition and contact formation; Binding required dimerization of PICK1, was dependent on PDZ domain protein interactions, and mediated stabilization of Neph1 at the plasma membrane.

  19. we have identified a homozygous mutation in the PICK1 gene that is associated with globozoospermia in humans

  20. The PICK1 mRNA is elevated in patient with schizophrenia.

Mouse (Murine) Protein Interacting With Protein Kinase C, alpha 1 (PICK1) interaction partners

  1. The beta cell-specific deletion of Pick1 in mice led to hyperglycemia and eventually to diabetes.

  2. Study demonstrates a key role of protein interacting with C-kinase 1 (PICK1) in mediating behavioral effects of cocaine. Data also revealed a so far unappreciated role of PICK1 in dopamine homeostasis that possibly involves negative regulation of striatal tyrosine hydroxylase levels.

  3. PICK1 Deficiency Induces Autophagy Dysfunction via Lysosomal Impairment and Amplifies Sepsis-Induced Acute Lung Injury

  4. the results indicate that PICK1 is a potent inhibitor of Parkin, and the reduction of PICK1 enhances the protective effect of Parkin.

  5. PICK1 regulates glutamateinduced exocytosis in beta cells.

  6. These results suggest that the PDZ domain of PICK1 directly interacts with calcineurin B in osteoclast progenitor cells and promotes osteoclast differentiation through activation of calcineurin-NFAT signaling.

  7. we summarize recent advances focusing on the structure and regulation of PICK1 and its functions in protein trafficking, neurological and non-neurological--{REVIEW}

  8. Ca(2+) influx through ASIC1 mediates chronic hypoxia and ET-1-induced NFATc3 nuclear import and 2) the scaffolding protein PICK1 is necessary for NFATc3 nuclear import.

  9. a dual role of PICK1 in regulating macrophage polarization

  10. This study demonstrated that d-serine provent the behavioral deficits in adult Pick1 knockout mice.

  11. PICK1 is an important regulator of P2Y6R expression and microglial phagocytosis.

  12. knocking-out PICK1 gene casts the neuroprotection effect by reducing ASICs current and the calcium transients in OGD-Rep neuronal cells

  13. ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis.

  14. results indicate that PICK1 is a crucial regulator in glutathione homeostasis and may play important roles in oxidative stress.

  15. In cultured neurons, PICK1 deletion increases surface AMPARs and blocks Abeta42-induced reduction in surface GluA2.

  16. This study demonstrated that PICK1 functions in vesicle biogenesis and is necessary to maintain normal vesicle numbers and size.

  17. C-terminal domain of ICA69 interacts with PICK1 and acts on trafficking of PICK1-PKCalpha complex and cerebellar plasticity.

  18. we found that PICK1's expression in testis rescued the spermatogenic abnormalities and male infertility in Pick1 knockout mice. Our results indicate that the infertility is caused by the lack of PICK1 in the testis rather than in other organs.

  19. PICK1 is a critical DHHC8 substrate whose palmitoylation is necessary for long-term depression

  20. PICK1 and ICA69 are key regulators of the formation and maturation of insulin granules.

PICK1 Protein Profile

Protein Summary

The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with PICK1

  • protein interacting with PRKCA 1 (PICK1)
  • protein interacting with C kinase 1 (Pick1)
  • protein interacting with PRKCA 1 (Pick1)
  • protein interacting with PRKCA 1 (pick1)
  • protein interacting with PRKCA 1 L homeolog (pick1.L)
  • DKFZp470L2127 protein
  • MGC131295 protein
  • PICK protein
  • PICK1 protein
  • prkcabp protein

Protein level used designations for PICK1

PRKCA-binding protein , protein interacting with C kinase 1 , protein kinase C-alpha-binding protein , protein kinase C, alpha binding protein , protein that interacts with C kinase 1 , protein interacting with PRKCA 1

GENE ID SPECIES
9463 Homo sapiens
18693 Mus musculus
84591 Rattus norvegicus
418030 Gallus gallus
533737 Bos taurus
610191 Canis lupus familiaris
734086 Xenopus (Silurana) tropicalis
735226 Xenopus laevis
100171712 Pongo abelii
100055023 Equus caballus
100158107 Sus scrofa
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