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May play a role in vesicle formation and transport (By similarity).. Additionally we are shipping PACSIN1 Antibodies (81) and PACSIN1 Proteins (7) and many more products for this protein.
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Specifically, CKS1B and MAP2K5 significantly inhibited hepatitis C viral RNA replication. PACSIN1, by contrast, inhibited hepatitis C virus infection by decreasing the level of viral protein p7.
syndapin I functions reflected direct, SH3 domain-mediated associations and functional interactions with ProSAP1/Shank2.
Data indicate that the structural capacity of N17 to fold back toward distal regions within huntingtin requires an interacting protein, protein kinase C and casein kinase 2 substrate in neurons 1 (PACSIN1).
Pacsin-1 plays a versatile role in sculpting cellular membranes that is likely dependent both on protein structure and membrane properties.
PACSIN1 represents a pDC-specific adaptor molecule that plays an important role in the TLR7/9-mediated type I IFN responses by pDCs in vitro and in vivo.
Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation
PACSIN 1 (1-344) was crystallized & diffracted to resolution of 3.0 A. The crystal belonged to space group C2, with unit-cell parameters a=158.65, b=87.38, c=91.76 A, alpha=90.00, beta=113.61, gamma=90.00 degrees. There are 2 molecules in asymmetric unit.
The regulated deformation of membranes and promotion of tubule constrictions by Pacsin suggests a more versatile function of these proteins in vesiculation and endocytosis.
Overall, the global native-KCC2 interactome and subsequent characterization revealed PACSIN1 as a novel and potent negative regulator of KCC2.
Structure and function analysis reveals a requirement for the PACSIN1 F-BAR and SH3 domains in controlling NMDA receptor-dependent processes.
The SdpI-binding site was mapped to a proline-rich sequence of 22 amino acids within the intracellular loop of GlyRbeta.
upon BDNF signaling PACSIN 1 is phosphorylated by CK2 which is essential for spine formation
PACSIN1 is an important Tau binding partner in regulating microtubule dynamics and forming axonal plasticity.
These results implicate Pak5 in Pacsin1- and Synaptojanin1-mediated synaptic vesicle trafficking.
syndapin I acts as pivotal membrane anchoring factor for dynamins during regeneration of synaptic vesicles.
These findings suggest a novel function for PACSIN proteins 1, 2, and 3 in dynamic microtubule nucleation.
May play a role in vesicle formation and transport (By similarity).
protein kinase C and casein kinase substrate in neurons 1
, protein kinase C and casein kinase substrate in neurons 2
, protein kinase C and casein kinase substrate in neurons protein 1
, syndapin 1
, syndapin I
, Syndapin I
, dynamin PRD-interacting protein
, dynamin proline-rich domain-interacting protein
, synaptic, dynamin-associated protein I