anti-Protein Kinase D3 (PRKD3) Antibodies

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. Additionally we are shipping Protein Kinase D3 Proteins (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PRKD3 23683 O94806
PRKD3 75292 Q8K1Y2
PRKD3 313834  
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Top anti-Protein Kinase D3 Antibodies at antibodies-online.com

Showing 10 out of 126 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated IF, IHC (p), WB   0.4 mL 4 to 8 Days
$522.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB   0.4 mL 4 to 8 Days
$522.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-PKCnu C-term Pab in NCI-H460 cell lysate western blot analysis of GFP fusion protein expression in Panc-1 cells by using an anti-GFP antibody. Lanes 1 and 5: non-transfected cells; lanes 2 and 6: GFP-PKD-transfected cells; lanes 3 and 7: GFP-PKD2-transfected cells; lanes 4 and 8: GFP-PKD3 transfected cells. Center panel, western blot analysis of GFP fusion protein expression in Panc-1 cells by using PKD3 N-term and C-term antibodies. Lower panel, indirect immunofluorescence analysis of GFP-PKD3 fusion protein expression in Panc-1 cells by using antibodies. Data courtesy of Dr. Osvaldo Rey, University of California Los Angeles. 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-PRKD3 Polyclonal Antibody, Unconjugated (ABIN754678) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat kidney tissue labeled with Anti-PRKD3 Polyclonal Antibody, Unconjugated (ABIN754678) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL 3 to 7 Days
$317.90
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of Prkd3 using rabbit polyclonal Mouse Prkd3 Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the Prkd3 gene. Mouse Prkd3 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded mouse duodenum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-PKCnu Pab in lysate of HL60 cells stimulated with PMA (lane A) and mouse brain tissue lysate (lane B) western blot analysis of GFP fusion protein expression in Panc-1 cells by using an anti-GFP antibody. Lanes 1 and 5: non-transfected cells; lanes 2 and 6: GFP-PKD-transfected cells; lanes 3 and 7: GFP-PKD2-transfected cells; lanes 4 and 8: GFP-PKD3 transfected cells. Center panel, western blot analysis of GFP fusion protein expression in Panc-1 cells by using PKD3 N-term and C-term antibodies. Lower panel, indirect immunofluorescence analysis of GFP-PKD3 fusion protein expression in Panc-1 cells by using antibodies. Data courtesy of Dr. Osvaldo Rey, University of California Los Angeles. 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of PRKD3 expression in HEK293 cells ,The lane on the left is treated with the antigen-specific peptide. 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$463.83
Details
Human Rabbit Un-conjugated IF, IHC, IHC (p), WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) 400 μL 11 to 14 Days
$493.17
Details
Human Rabbit Un-conjugated IHC, ELISA, WB IHC analysis of FFPE human hepatocarcinoma tissue stained with the PKC nu antibody Western blot analysis of PKC nu antibody and NCI-H460 cell lysate 0.4 mL 2 to 3 Days
$452.38
Details

Top referenced anti-Protein Kinase D3 Antibodies

  1. Human Polyclonal PRKD3 Primary Antibody for IP, WB - ABIN250697 : Watkins, Lewandowski, Meek, Storz, Toker, Piwnica-Worms: Phosphorylation of the Par-1 polarity kinase by protein kinase D regulates 14-3-3 binding and membrane association. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 6 Pubmed References

  2. Human Polyclonal PRKD3 Primary Antibody for WB - ABIN541112 : Nakashima: Protein kinase C alpha (PKC alpha): regulation and biological function. in Journal of biochemistry 2002 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal PRKD3 Primary Antibody for IF, IHC (p) - ABIN545469 : Matthews, Dayalu, Thompson, Scharenberg: Regulation of protein kinase Cnu by the B-cell antigen receptor. in The Journal of biological chemistry 2003 (PubMed)
    Show all 3 Pubmed References

  4. Human Monoclonal PRKD3 Primary Antibody for ELISA, WB - ABIN565151 : Borges, Döppler, Perez, Andorfer, Sun, Anastasiadis, Thompson, Geiger, Storz: Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis. in Breast cancer research : BCR 2014 (PubMed)

  5. Human Polyclonal PRKD3 Primary Antibody for IF, IHC (p) - ABIN545468 : Chen, Deng, Singh, Wang: Protein kinase D3 (PKD3) contributes to prostate cancer cell growth and survival through a PKCepsilon/PKD3 pathway downstream of Akt and ERK 1/2. in Cancer research 2008 (PubMed)

More Antibodies against Protein Kinase D3 Interaction Partners

Human Protein Kinase D3 (PRKD3) interaction partners

  1. exogenous SCF, CCL5 and CCL11 reversed the effect on MCs migration inhibited by PKD2/3 silencing. Mechanistically, PKD2/3 interacted with Erk1/2 and activated Erk1/2 or NF-kappaB signaling pathway, leading to AP-1 or NF-kappaB binding to the promoter of scf, ccl5 and ccl11.

  2. Our findings suggest that abnormal PKD3 expression might contribute to hepatocellular carcinoma progression. Furthermore, high PKD3 expression predicts a poor prognosis in hepatocellular carcinoma patients after hepatectomy

  3. The enriched pathway analysis reveals that PRKD3 regulates pathways contributing to multiple cancer related events, including cell cycle, migration and others.

  4. None of the Polymorphous low-grade adenocarcinoma (PLGA) lacking PRKD1 somatic mutations or PRKD gene family rearrangements harboured somatic mutations in the kinase domains of the PRKD2 or PRKD3 genes.

  5. This study discovered and characterized a novel, highly conserved N-terminal domain, comprising 92 amino acids, which mediates dimerization of Protein Kinase D (PKD) isoforms, PKD1, PKD2, and PKD3 monomers.

  6. Studies indicate that the loss of protein kinase D PKD1 is thought to promote invasion and metastasis, while PKD2 and upregulated PKD3 to be positive regulators of proliferation.

  7. Loss of PKD2 enhanced KC proliferative potential while loss of PKD3 resulted in a progressive proliferation defect, loss of clonogenicity and diminished tissue regenerative ability.

  8. for the first time, PKD3 is implicated in the transcription activation of latent HIV-1 provirus, and our results revealed a molecular mechanism of prostratin-induced HIV-1 transcription via PKCepsilon/PKD3/NF-kappaB signaling pathway.

  9. Activation of PKD2 and further increase of PKD3 activity leads to additional phosphorylation and inhibition of endogenous phosphatase slingshot 1L.

  10. PKD3 in TNBC cells provides a molecular connection between the Golgi and endolysosomal compartments to enhance proliferative mTORC1-S6K1 signaling.

  11. PKD3 negatively regulates human airway epithelial barrier formation and integrity through down-regulation of claudin-1, which is a key component of tight junctions.

  12. PKD3 may contribute to the malignant progression of prostate cancer cells through negative regulation of MMP-7 expression.

  13. PKD3 contributes to the proliferation and malignant growth of androgen-dependent prostate cancer cells in part by upregulating PSA expression.

  14. We have identified PKD2 and PKD3, especially PKD3, as novel cell growth regulators in HCC1806 triple-negative breast cancer cells

  15. PKD antagonists inhibited differentiation and viability of human hematopoietic stem cells, and had less HDAC phosphorylation, confirming the need for PKD-HDAC signaling in erythropoiesis.

  16. phosphorylation of GIT1 on serine 46 by PKD3 represents a molecular switch by which GIT1 localization, paxillin trafficking, and cellular protrusive activity are regulated.

  17. Data demonstrate the functional role of protein kinase D1 and protein kinase D3 in modulating physiological responses to Ox1R activation.

  18. Novel isoforms regulate human keratinocyte differentiation by activating a p38 delta mitogen-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha.

  19. PKCnu is an important component of signaling pathways downstream from novel PKC enzymes after B-cell receptor engagement

  20. the effect of G protein-coupled receptor agonists on the regulatory properties, continuous shuttling, and intracellular distribution of Protein kinase C nu/protein kinase D3

Mouse (Murine) Protein Kinase D3 (PRKD3) interaction partners

  1. These data provide new insights of a specific PKD3 signaling pathway by identifying a new function, which has not been identified before.

  2. Erythropoietin regulates GATA1 through protein kinase D activation, promoting histone deacetylase 5 dissociation from GATA1, and subsequent GATA1 acetylation.

  3. These data validate PKD3 as a promising therapeutic target in prostate cancer and shed light on the role of secreted tumor-promoting factors in prostate cancer progression.

  4. PKCnu is an important component of signaling pathways downstream from novel PKC enzymes after B-cell receptor engagement

  5. the catalytic activity of PKD3 may regulate its nuclear import through autophosphorylation and/or interaction with another protein

  6. PKD3 is increasingly expressed in neuronal as well as in the supporting connective tissue and in skeletal muscles

  7. reveal a novel distinction between the exocrine and endocrine cells of the pancreas and further identify PKD3 as a signaling molecule that promotes hormone-stimulated amylase secretion

Protein Kinase D3 (PRKD3) Antigen Profile

Protein Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the involvement of other PKC family members.

Gene names and symbols associated with PRKD3

  • protein kinase D3 (PRKD3) antibody
  • protein kinase D3 (prkd3) antibody
  • protein kinase D3 (Prkd3) antibody
  • 4930557O20Rik antibody
  • 5730497N19Rik antibody
  • EPK2 antibody
  • nPKC-NU antibody
  • PKC-NU antibody
  • Pkcnu antibody
  • PKD3 antibody
  • Prkcn antibody
  • PRKD3 antibody

Protein level used designations for PRKD3

protein kinase C nu type , protein kinase C, nu , protein kinase EPK2 , protein-serine/threonine kinase , serine/threonine-protein kinase D3 , protein kinase D3 , serine/threonine-protein kinase D3-like , nPKC-nu

GENE ID SPECIES
23683 Homo sapiens
421478 Gallus gallus
459158 Pan troglodytes
483036 Canis lupus familiaris
538447 Bos taurus
709647 Macaca mulatta
100397078 Callithrix jacchus
100438207 Pongo abelii
100466224 Ailuropoda melanoleuca
100523181 Sus scrofa
100077901 Ornithorhynchus anatinus
100563064 Anolis carolinensis
100581692 Nomascus leucogenys
75292 Mus musculus
313834 Rattus norvegicus
100712662 Cavia porcellus
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