Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A Proteins (PPP1R14A)

Zebrafish Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A) interaction partners

1. Hoxb1b is likely to directly regulate ppp1r14al expression in rhombomere 4. Furthermore, ppp1r14al is essential for establishment of the earliest hindbrain signaling-center in rhombomere 4 by regulating expression of fgf3.

Human Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A) interaction partners

1. CPI-17 drives Ras activity and tumorigenesis in melanomas in a two-fold way; inactivation of the tumor suppressor merlin and activation of the growth promoting ERM family.

2. The authors call the mutual sequestration mechanism through which pCPI-17 and myosin light-chain phosphatase interact inhibition by unfair competition: myosin light-chain phosphatase protects pCPI-17 from other phosphatases, while pCPI-17 blocks other substrates from the active site of myosin light-chain phosphatase.

3. Study finds that CPI-17 (PPP1R14A protein phosphatase 1 regulatory inhibitor subunit 14A, 17 kDa) is not expressed in the healthy peripheral nervous system or in nontumour pathologies of the peripheral nervous system. CPI-17 up-regulation, however, is observed in over 90% of schwannomas, but not in neurofibroma and only rarely in malignant peripheral nerve sheath tumour.

4. CPI-17 has a role in restoring skin homoeostasis in cutaneous field of cancerization lesions

5. analysis of the interaction between plakoglobin and CPI-17, which is affected by the phosphorylation status of CPI-17 in human lung microvascular endothelial cells

6. The N-terminal 21-residue tail domain of CPI-17 is necessary for nuclear localization. Phospho-mimetic Asp-substitution of CPI-17 at Ser12 attenuates the nuclear import.

7. The study characterized the CPI-17 promoter and identified binding sites for GATA-6 and nuclear factor kappa B (NF-kappaB).

8. a novel signaling cascade that links RhoA-mediated calcium sensitivity to MEF2-dependent myocardin expression in VSMCs through a mechanism involving p38 MAPK, PP1alpha, and CPI-17.

9. RACK1 may play a role in PKC/CPI-17 signaling pathway.

10. cAMP/PKA regulates the endothelial barrier via inhibition of the contractile machinery, mainly by the activation of MLCP via inhibition of CPI-17 and RhoA/Rock.

11. mapped to chromosome 19q13.13-q13.2

12. CPI-17 binds directly to protein kinase C and casein kinase I.

13. importance of PKC/CPI-17-mediated pathway in histamine-triggered cytoskeletal rearrangements leading to lung microvascular barrier compromise.

14. CPI-17 siRNA decreased the level of merlin phosphorylation and consequently Ras and ERK activity in human tumor cell lines

15. These data indicate that 14,15-epoxyeicosatrienoic acid hyperpolarizes airway smooth muscle cells and relaxes precontracted human bronchi and intracellular effects are related to a PKC-dependent process involving a lower phosphorylation level of CPI-17.

16. Human pregnancy is characterized by increases in PKN1 expression and PPP1R14A phosphorylation in the myometrium.

17. These results are consistent with a key molecular role for CPI-17 in airway hyperresponsiveness, in the absence of bronchial wall remodeling.

18. NF2 is rendered inactive by phosphorylation of Ser 518 and this can be explained at least in part by an increased expression of CPI-17.

Mouse (Murine) Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A) interaction partners

1. CPI-17 phosphorylation at T38 is essential for the maintenance of physiological blood pressure.

2. Enhanced vasorelaxation in early endotoxemia is mediated by redox signaling through PKG-1alpha but in later endotoxemia by myosin phosphatase isoform shifts enhancing sensitivity to NO/cGMP as well as smooth muscle atrophy.

3. The study characterized the CPI-17 promoter and identified binding sites for GATA-6 and nuclear factor kappa B (NF-kappaB).

4. a novel signaling cascade that links RhoA-mediated calcium sensitivity to MEF2-dependent myocardin expression in VSMCs through a mechanism involving p38 MAPK, PP1alpha, and CPI-17.

5. Data suggest that CPI-17 and both conventional and novel PKC isozymes contribute to the phasic and tonic contractile components of BALB/c colonic circular smooth muscle.

6. Organ-specific mechanisms involving MYPT1, M-RIP, and CPI-17 are critical to regulating basal LC20 phosphorylation in gastrointestinal smooth muscles.

7. calcium-independent phospholipase A2beta has a role in high glucose-induced activation of RhoA, Rho kinase, and CPI-17 in cultured vascular smooth muscle cells and vascular smooth muscle hypercontractility in diabetic animals

8. distribution of mouse and rat PPP1R14A was more specific and different from that of humans

9. concluded that actions downstream of cGMP/PKG can reverse PKC-mediated phosphorylation of CPI-17 and Ca(2+) sensitization in smooth muscle

10. findings suggest that CPI-17 was downregulated during intestinal inflammation and that TNF-alpha plays a central role in this process. Downregulation of CPI-17 may play a role in motility impairments in inflammation.

11. CPI-17 expression is reversibly controlled in response to the phenotype transition of smooth muscle cells that restricts the signal to differentiated smooth muscle cells and particular cell types.

Pig (Porcine) Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A) interaction partners

1. This study examined the protein expression and spatial-temporal distribution of PKCalpha and CPI-17 in intact smooth muscle tissues.