Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A Proteins (PPP1R14A)

Zebrafish Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A) interaction partners

1. Hoxb1b is likely to directly regulate ppp1r14al expression in rhombomere 4. Furthermore, ppp1r14al is essential for establishment of the earliest hindbrain signaling-center in rhombomere 4 by regulating expression of fgf3 (show FGF3 Proteins).

Human Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A) interaction partners

1. CPI-17 drives Ras activity and tumorigenesis in melanomas in a two-fold way; inactivation of the tumor suppressor merlin (show NF2 Proteins) and activation of the growth promoting ERM (show ETV5 Proteins) family.

2. The authors call the mutual sequestration mechanism through which pCPI-17 and myosin light-chain phosphatase interact inhibition by unfair competition: myosin light-chain phosphatase protects pCPI-17 from other phosphatases, while pCPI-17 blocks other substrates from the active site of myosin light-chain phosphatase.

3. Study finds that CPI-17 (PPP1R14A protein phosphatase 1 regulatory inhibitor subunit 14A, 17 kDa) is not expressed in the healthy peripheral nervous system or in nontumour pathologies of the peripheral nervous system. CPI-17 up-regulation, however, is observed in over 90% of schwannomas, but not in neurofibroma and only rarely in malignant peripheral nerve sheath tumour.

4. CPI-17 has a role in restoring skin homoeostasis in cutaneous field of cancerization lesions

5. analysis of the interaction between plakoglobin (show JUP Proteins) and CPI-17, which is affected by the phosphorylation status of CPI-17 in human lung microvascular endothelial cells

6. The N-terminal 21-residue tail domain of CPI-17 is necessary for nuclear localization. Phospho-mimetic Asp (show ASIP Proteins)-substitution of CPI-17 at Ser12 attenuates the nuclear import.

7. The study characterized the CPI-17 promoter and identified binding sites for GATA-6 (show GATA6 Proteins) and nuclear factor kappa B (NF-kappaB (show NFKB1 Proteins)).

8. a novel signaling cascade that links RhoA (show RHOA Proteins)-mediated calcium sensitivity to MEF2 (show MEF2A Proteins)-dependent myocardin expression in VSMCs through a mechanism involving p38 MAPK (show MAPK14 Proteins), PP1alpha (show PPP1CA Proteins), and CPI-17.

9. RACK1 (show GNB2L1 Proteins) may play a role in PKC (show PRRT2 Proteins)/CPI-17 signaling pathway.

10. cAMP/PKA regulates the endothelial barrier via inhibition of the contractile machinery, mainly by the activation of MLCP via inhibition of CPI-17 and RhoA (show RHOA Proteins)/Rock.

Mouse (Murine) Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A) interaction partners

1. Enhanced vasorelaxation in early endotoxemia is mediated by redox signaling through PKG-1alpha but in later endotoxemia by myosin phosphatase isoform shifts enhancing sensitivity to NO/cGMP as well as smooth muscle atrophy.

2. The study characterized the CPI-17 promoter and identified binding sites for GATA-6 (show GATA6 Proteins) and nuclear factor kappa B (NF-kappaB (show NFKB1 Proteins)).

3. a novel signaling cascade that links RhoA (show RHOA Proteins)-mediated calcium sensitivity to MEF2 (show MEF2C Proteins)-dependent myocardin expression in VSMCs through a mechanism involving p38 MAPK (show MAPK14 Proteins), PP1alpha (show PPP1CA Proteins), and CPI-17.

4. Data suggest that CPI-17 and both conventional and novel PKC isozymes contribute to the phasic and tonic contractile components of BALB/c colonic circular smooth muscle.

5. Organ-specific mechanisms involving MYPT1 (show PPP1R12A Proteins), M-RIP, and CPI-17 are critical to regulating basal LC20 (show MYL9 Proteins) phosphorylation in gastrointestinal smooth muscles.

6. calcium-independent phospholipase A2beta has a role in high glucose-induced activation of RhoA (show RHOA Proteins), Rho kinase (show ROCK2 Proteins), and CPI-17 in cultured vascular smooth muscle cells and vascular smooth muscle hypercontractility in diabetic animals

7. distribution of mouse and rat PPP1R14A was more specific and different from that of humans

8. concluded that actions downstream of cGMP/PKG (show PRKG1 Proteins) can reverse PKC-mediated phosphorylation of CPI-17 and Ca(2 (show CA2 Proteins)+) sensitization in smooth muscle

9. findings suggest that CPI-17 was downregulated during intestinal inflammation and that TNF-alpha (show TNF Proteins) plays a central role in this process. Downregulation of CPI-17 may play a role in motility impairments in inflammation.

10. CPI-17 expression is reversibly controlled in response to the phenotype transition of smooth muscle cells that restricts the signal to differentiated smooth muscle cells and particular cell types.

Pig (Porcine) Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A) interaction partners

1. This study examined the protein expression and spatial-temporal distribution of PKCalpha (show PKCa Proteins) and CPI-17 in intact smooth muscle tissues.