CPI-17 Protein (His tag)
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- Target See all CPI-17 (PPP1R14A) Proteins
- CPI-17 (PPP1R14A) (Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This CPI-17 protein is labelled with His tag.
- Purpose
- Recombinant Human PPP1R14A Protein (His Tag)
- Sequence
- Met 1-Pro147
- Characteristics
- Recombinant Human Protein Phosphatase 1 Regulatory Subunit 14A is produced by our E.coli expression system and the target gene encoding Met1-Pro147 is expressed with a 6His tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product PPP1R14A Protein
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Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A) (AA 1-147) protein (GST tag)
PPP1R14A Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A) (AA 1-147) protein (Strep Tag)Crystallography grade PPP1R14A Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A) (AA 1-147) protein (Strep Tag)Crystallography grade PPP1R14A Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A) protein (Myc-DYKDDDDK Tag)PPP1R14A Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 0.2 mM EDTA, 1 mM DTT, 10 % Glycerol, pH 8.0.
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- CPI-17 (PPP1R14A) (Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A))
- Alternative Name
- PPP1R14A (PPP1R14A Products)
- Synonyms
- MGC81874 Protein, cpi-17 Protein, ppp1inl Protein, CPI-17 Protein, im:7147597 Protein, ppp1r14a Protein, zgc:110700 Protein, PPP1R14A Protein, CPI17 Protein, PPP1INL Protein, Cpi17 Protein, 1110001M11Rik Protein, protein phosphatase 1 regulatory inhibitor subunit 14A L homeolog Protein, protein phosphatase 1 regulatory inhibitor subunit 14A Protein, protein phosphatase 1, regulatory (inhibitor) subunit 14Aa Protein, protein phosphatase 1, regulatory (inhibitor) subunit 14A Protein, ppp1r14a.L Protein, ppp1r14a Protein, ppp1r14aa Protein, PPP1R14A Protein, Ppp1r14a Protein
- Background
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Background: Protein Phosphatase 1 Regulatory Subunit 14A (PPP1R14A) belongs to the PP1 inhibitor family. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. Meantime, PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. PPP1R14A is the inhibitor of PPP1CA. When phosphorylated, PPP1R14A has over 1000-fold higher inhibitory activity, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. In addition, inhibition of PPP1R14A also enhances contraction of smooth muscle in the absence of increment of intracellular Ca2+ concentration.
Synonym: Protein Phosphatase 1 Regulatory Subunit 14A, 17 kDa PKC-Potentiated Inhibitory Protein of PP1, Protein Kinase C-Potentiated Inhibitor Protein of 17 kDa, CPI-17, PPP1R14A, CPI17, PPP1INL
- Molecular Weight
- 17.8 kDa
- UniProt
- Q96A00
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