Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B (PPP1R1B) ELISA Kits

PPP1R1B encodes a bifunctional signal transduction molecule. Additionally we are shipping Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B Antibodies (238) and Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B Proteins (8) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
PPP1R1B 360616 Q6J4I0
PPP1R1B 84152 Q9UD71
PPP1R1B 19049 Q60829
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Top Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B ELISA Kits at

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Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 0.054 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests 13 to 16 Days
  2 x 96 Tests 2 to 3 Days

More ELISA Kits for Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B Interaction Partners

Rhesus Monkey Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B (PPP1R1B) interaction partners

  1. DARPP-32 and I-1 were most frequently identified in dendritic shafts, unlike the D1R and PP1 isoforms. Moreover, DARPP-32 and I-1 were only present in approximately 4% and 8% of area 9 pyramidal cell spines, respectively.

Human Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B (PPP1R1B) interaction partners

  1. Single nucleotide polymorphisms related to dopamine are associated with individual differences in exploration strategies. Variation in a gene linked to prefrontal dopamine (COMT) predicted the degree of directed exploration, as well as the overall randomness of responding. Variation in a gene linked to striatal dopamine (DARPP-32) predicted the degree of both directed and random exploration.

  2. t-Darpp phosphorylation at T39 seems to be crucial for t-Darpp-mediated PKA activation and this activation appears to occur through an association with RI and sequestering of RI away from PKAc. The t-Darpp-RI interaction could be a druggable target to reduce PKA activity in drug-resistant cancer.

  3. our results lend support for a potential role of DARPP-32 genetic variants in neural response to potential reward triggering cues

  4. To facilitate live-cell identification, a human embryonic stem cell line was generated using CRISPR-mediated gene editing at the DARPP32 locus.

  5. Study associates polymorphisms in DRD2, DARPP-32, and COMT genes with novel category learning performance. Modeling results suggest that striatal dopaminergic genes influence selective attention processes whereas cortical genes mediate the ability to update complex rule representations.

  6. Results show that expression of human DARPP-32 protein isoforms depends on the striatal neurodevelopmental stage with t-DARPP being specific for the human adult striatum.

  7. In vivo xenograft models demonstrated that overexpression of DARPP-32 promotes angiogenesis and tumour growth.

  8. This study strongly suggests that inflammation-regulated DARPP-32 constitutes a key component of H. pylori-mediated gastric tumourigenesis.

  9. This study did not find any statistical difference in the state-anxiety dimension for the rs12601930C/T, rs879606A/G, and rs3764352A/G genotypes, but statistical differences in the trait-anxiety dimension for the rs879606A/G (F = 5.207, P = 0.006) and rs3764352A/G (F = 3.960, P = 0.020) genotype.

  10. DARPP-32 is mainly cleaved at Thr(153) by calpain and this cleavage of DARPP-32 reduces CREB phosphorylation via loss of its inhibitory function on PP1; results suggest a novel mechanism of DARPP-32-CREB signalling dysregulation in Alzheimer's disease

  11. No significant differences in mRNA expression levels of DRD2 and DARPP-32 were found among controls, patients with psychotic disorder not otherwise specified, and schizophrenia/schizophreniform disorder.

  12. Striatal function was indexed by a gene coding for DARPP-32, which is densely expressed in the striatum where it is necessary for synaptic plasticity

  13. Findings show that PPP1R1B-STARD3 fusion transcript has a key role in subsets of gastric cancers through the activation of PI3K/AKT signaling.

  14. The results of this study found that the mean t-DARPP expression level in the caudate was higher in patients with schizophrenia than in control individuals.

  15. Results suggest that variation in PPP1R1B affects the abundance of the splice variant t-DARPP-32 mRNA and may reflect potential molecular mechanisms implicated in schizophrenia and affective disorders

  16. The immunostaining was more decreased for DARPP-32 than for the morphological changes of striatal neurons in multiple system atrophy.

  17. This study showed that variations in genotypes relevant for DARPP-32 functions are associated more with aging-related impairments in the explicit than the implicit component of sequence learning.

  18. density of DARPP-32-immunoreactive (IR) neurons in the II and III layers of the RAIC was significantly decreased (p<0.05) in the schizophrenia group compared with the healthy control group.

  19. Bcl-2 and DARPP-32 have roles in regulating inositol 1,4,5-trisphosphate receptor phosphorylation and promoting cell survival

  20. High DARPP32/STAT3, DARPP32/STAT5B, and STAT5B/STAT3 ratios were associated with longer patient progression free survival.

Mouse (Murine) Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B (PPP1R1B) interaction partners

  1. This study strongly suggests that inflammation-regulated DARPP-32 constitutes a key component of H. pylori-mediated gastric tumourigenesis.

  2. the results suggest that by inducing dephosphorylation of DARPP-32 at Ser-97 and altering its cytonuclear distribution, glutamate may counteract dopamine/D1 receptor/PKA signaling at multiple cellular levels.

  3. Darpp32 interaction with beta-adducin may be the molecular pathway by which environmental changes may rapidly alter responsiveness of striatal neurons involved in the reward system.

  4. Results show that Darpp-32 was expressed in normal mouse mammary tissue and in some breast tumors, whereas t-Darpp was found exclusively in mammry tumors.

  5. analysis of cAMP-activated DARPP-32 signalling to the nucleus

  6. Results describe the development of new vascular mouse model with a conditional knockout allele of Tsc1 with a Darpp32-Cre allele. This mouse displayed accelerated formation of both kidney cystadenomas and paw hemangiosarcomas.

  7. Cannabinoid-stimulated G-protein activity did not differ between DARPP-32 KO and WT mice treated with vehicle or repeated THC.

  8. In this work, the dissected postsynaptic topology of the DARPP-32 phosphoprotein provides strong evidence for a compartmentalized and confined distribution in dendritic spines.

  9. Adenosine AA receptors in striatal glutamatergic terminals and GABAergic neurons oppositely modulate psychostimulant action and DARPP-32 phosphorylation.

  10. Data suggest that histone deacetylase inhibitors inhibit the induction of NGF1A-binding protein Nab2 by brain derived neurotrophic factor (BDNF), and thereby the relative induction of dopamine and cyclic AMP-regulated phosphoprotein, 32 kDa (DARPP-32).

  11. This study demonistrated that environment enhanced Darpp32 expression in brain and enhanced totaroad perfermance and short term working menory.

  12. DARPP32 has a role in pluripotent stem cell differentiation toward medium-sized spiny neurons

  13. l-DOPA-induced activation of ERK and mTORC1 requires DARPP-32 and indicates the importance of the cAMP/DARPP-32 signaling cascade in dyskinesia.

  14. DARPP-32 increases interactions between epidermal growth factor receptor and ERBB3 to promote tumor resistance to gefitinib.

  15. Data show that the loss of DARPP-32 in striatopallidal neurons produced a robust increase in locomotor activity.

  16. results indicate that under chronic dopamine deficiency (a) the A(2A)/cAMP/PKA/DARPP-32 cascade is overactive due to the elevated endogenous phospho-DARPP-32 levels and (b) the A(2A) receptor modulatory effect on ERK1/2 signaling is dysregulated

  17. Our data demonstrate that beta(1)- and alpha(2)-adrenoceptors regulate DARPP-32 phosphorylation in neostriatal neurons.

  18. Data confirmed that CR specifically increased dopamine- and cAMP-regulated phosphoprotein (Darpp-32), a key regulator of dopamine receptor signaling, in the amygdala.

  19. DARPP-32 is essential not only for dopaminergic but also for serotonergic neurotransmission.

  20. stimulatory effect of caffeine on motor activity in mice was greatly reduced following genetic deletion of DARPP-32 (dopamine- and cyclic AMP-regulated phosphoprotein of relative molecular mass 32,000)

Xenopus laevis Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B (PPP1R1B) interaction partners

  1. Areas of brain and spinal cord that are densely innervated by tyrosine hydroxylase-immunoreactive fibers display a remarkable immunoreactivity for DARPP-32/ppp1r1b in cell bodies and neuropil.

Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B (PPP1R1B) Antigen Profile

Antigen Summary

This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PPP1R1B

  • protein phosphatase 1 regulatory inhibitor subunit 1B (ppp1r1b) antibody
  • protein phosphatase 1 regulatory inhibitor subunit 1B (PPP1R1B) antibody
  • protein phosphatase 1, regulatory (inhibitor) subunit 1B (Ppp1r1b) antibody
  • protein phosphatase 1 regulatory inhibitor subunit 1B S homeolog (ppp1r1b.S) antibody
  • AU040756 antibody
  • DARPP-32 antibody
  • DARPP32 antibody

Protein level used designations for PPP1R1B

protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32) , neuronal phosphoprotein DARPP-32 , protein phosphatase 1 regulatory subunit 1B , protein phosphatase 1, regulatory (inhibitor) subunit 1B , dopamine- and cAMP-regulated neuronal phosphoprotein , dopamine- and cAMP-regulated phosphoprotein DARPP-32 , dopamine and cAMP-regulated neuronal phosphoprotein 32 , DARPP-32 , dopamine and cAMP regulated

100124928 Xenopus (Silurana) tropicalis
574203 Macaca mulatta
608394 Canis lupus familiaris
744755 Pan troglodytes
100355399 Oryctolagus cuniculus
100736966 Sus scrofa
360616 Rattus norvegicus
84152 Homo sapiens
19049 Mus musculus
733416 Xenopus laevis
282459 Bos taurus
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