Protein Phosphatase 1, Regulatory Subunit 8 Proteins (PPP1R8)

PPP1R8, through alternative splicing, encodes three different isoforms. Additionally we are shipping Protein Phosphatase 1, Regulatory Subunit 8 Antibodies (103) and Protein Phosphatase 1, Regulatory Subunit 8 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PPP1R8 5511 Q12972
Rat PPP1R8 PPP1R8 313030  
PPP1R8 100336 Q8R3G1
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Top Protein Phosphatase 1, Regulatory Subunit 8 Proteins at antibodies-online.com

Showing 6 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
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Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days
$400.00
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,955.33
Details

PPP1R8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

More Proteins for Protein Phosphatase 1, Regulatory Subunit 8 (PPP1R8) Interaction Partners

Human Protein Phosphatase 1, Regulatory Subunit 8 (PPP1R8) interaction partners

  1. NIPP1 could be activated by hypoxia and contributed to hypoxia-induced invasive and metastatic potential in hepatocellular carcinoma.

  2. Data suggest overexpression of NIPP1 in HeLa cells causes induction of genes of mesenchymal lineage with reduction in cell proliferation; thus, key dephosphorylation events may be involved in epithelial-mesenchymal transition or transdifferentiation.

  3. PP1 (show PPA1 Proteins)/NIPP1 is a novel molecular compass that controls directed cell migration.

  4. The molecular basis by which NIPP1 directs PP1 substrate specificity in the nucleus.

  5. The protein phosphatase-1 (show PPP1CB Proteins) regulator NIPP1 is also a splicing factor (show SLU7 Proteins) involved in a late step of spliceosome assembly

  6. NIPP1 has a role in the nuclear targeting and/or retention of PP1

  7. We demonstrate that interaction with NIPP1 mediates decreased PP1gamma activity in hypoxia, an event which may constitute an inherent part of the cellular oxygen-sensing machinery and may play a role in physiologic adaptation to hypoxia.

  8. Required for the global trimethylation of histone3 at lysine27 and is implicated in gene silencing by enhancer of zeste homolog (EZH)2.

  9. NIPP1 is present in a complex with EED (show EED Proteins) and EZH2 (show EZH2 Proteins) in vivo and has distinct binding sites for these proteins.

  10. NMR structure of the NIPP1 FHA (show CRY2 Proteins) domain.

Mouse (Murine) Protein Phosphatase 1, Regulatory Subunit 8 (PPP1R8) interaction partners

  1. NIPP1 does not regulate the proliferation of hepatocytes but is a suppressor of biliary epithelial cell proliferation, including progenitor cells, in the adult liver.

  2. activation of the RAGE (show AGER Proteins) by advanced glycation end products or other ligands suppresses NIPP1 expression in diabetic nephropathy, contributes to podocyte hypertrophy, and glomerular inflammation

  3. NIPP1(-/-) embryos showed severely retarded growth at embryonic day 6.5 (E6.5) and were resorbed by E8.5. This early embryonic lethality was not associated with increased apoptosis but correlated with impaired cell proliferation.

  4. NIPP1 has a role in the nuclear targeting and/or retention of PP1

  5. Required for the global trimethylation of Histone 3 at Lysine 27 and is implicated in gene silencing by enhancer of zeste homolog (EZH)2 (show EZH2 Proteins).

Protein Phosphatase 1, Regulatory Subunit 8 (PPP1R8) Protein Profile

Protein Summary

This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.

Gene names and symbols associated with PPP1R8

  • protein phosphatase 1 regulatory subunit 8 (PPP1R8)
  • protein phosphatase 1, regulatory subunit 8 (Ppp1r8)
  • protein phosphatase 1, regulatory (inhibitor) subunit 8 (Ppp1r8)
  • protein phosphatase 1, regulatory subunit 8b (ppp1r8b)
  • protein phosphatase 1 regulatory subunit 8 L homeolog (ppp1r8.L)
  • protein phosphatase 1 regulatory subunit 8 (Ppp1r8)
  • protein phosphatase 1, regulatory subunit 8a (ppp1r8a)
  • protein phosphatase 1 regulatory subunit 8 S homeolog (ppp1r8.S)
  • 6330548N22Rik protein
  • ard-1 protein
  • ard1 protein
  • AU044684 protein
  • nipp-1 protein
  • nipp1 protein
  • ppp1r8 protein
  • PRO2047 protein
  • si:ch211-206a7.1 protein

Protein level used designations for PPP1R8

RNase E , activator of RNA decay , nuclear inhibitor of protein phosphatase 1 , nuclear inhibitor of protein phosphatase-1 alpha , nuclear subunit of PP-1 , protein phosphatase 1 regulatory subunit 8 , protein phosphatase 1, regulatory (inhibitor) subunit 8 , NIPP-1 , protein phosphatase 1 regulatory inhibitor subunit 8 , protein phosphatase 1, regulatory inhibitor subunit 8 , uncharacterized protein LOC799896 , protein phosphatase 1, regulatory (inhibitor) subunit 8a , protein phosphatase 1, regulatory subunit 8a , protein phosphatase 1 regulatory subunit 8 S homeolog

GENE ID SPECIES
5511 Homo sapiens
313030 Rattus norvegicus
100336 Mus musculus
282319 Bos taurus
799896 Danio rerio
398974 Xenopus laevis
419564 Gallus gallus
487340 Canis lupus familiaris
100722083 Cavia porcellus
566830 Danio rerio
779310 Xenopus laevis
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