Protein tyrosine Phosphatase, Receptor Type, B Proteins (PTPRB)

The protein encoded by PTPRB is a member of the protein tyrosine phosphatase (PTP) family. Additionally we are shipping PTPRB Antibodies (22) and PTPRB Kits (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTPRB 314843  
PTPRB 5787 P23467
PTPRB 19263 B2RU80
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Top PTPRB Proteins at antibodies-online.com

Showing 9 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$688.00
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$704.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$860.20
Details
Escherichia coli (E. coli) Human His-SUMO Tag   50 μg Log in to see 11 Days
$341.00
Details
Yeast Human His tag   50 μg Log in to see 8 to 11 Days
$341.00
Details
Escherichia coli (E. coli) Rat His tag   100 μg Log in to see 15 to 18 Days
$720.00
Details
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$639.61
Details

PTPRB Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human , , ,
, , ,
Mouse (Murine) ,
,

More Proteins for Protein tyrosine Phosphatase, Receptor Type, B (PTPRB) Interaction Partners

Human Protein tyrosine Phosphatase, Receptor Type, B (PTPRB) interaction partners

  1. PTPRB was down-regulated in non-small-cell lung cancer patients and was associated with patient overall survival.

  2. STIM1 (show STIM1 Proteins)-induced Ca(2 (show CA2 Proteins)+) signaling activates Pyk2 (show PTK2B Proteins) to inhibit the interaction of VE-PTP and VE-cadherin (show CDH5 Proteins) and hence increase endothelial permeability.

  3. Results provide evidence that PTPRB and PLCG1 (show PLCG1 Proteins) mutations are driving events in a subset of secondary angiosarcomas.

  4. VE-PTP activates TIE2 (show TEK Proteins) and stabilizes retinal and choroidal blood vessels

  5. these results suggest that the polarized redistribution of VE-PTP in response to shear stress plays an important role in the regulation of endothelial cells function by blood flow.

  6. The endothelial phosphatase PTPRB, a negative regulator of vascular growth factor tyrosine kinases, harbored predominantly truncating mutations in 10 of 39 angiosarcoma tumors.

  7. zinc(II) ions regulate receptor protein-tyrosine phosphatase (show PTPRT Proteins) beta activity at picomolar concentrations.

  8. vascular endothelial protein tyrosine phosphatase contributes to endothelial morphogenesis. Silencing of VE-PTP expression was accompanied by increased VEGF receptor-2 tyrosine phosphorylation and activation of downstream signaling pathways.

  9. Suggest that VE-PTP, in cooperation with integrins, regulates the spreading and migration of endothelial cells during angiogenesis.

  10. The PTP1B (show PTPN1 Proteins) has been observed over expressed in human breast cancer patients, suggesting its role in cell proliferation.

Mouse (Murine) Protein tyrosine Phosphatase, Receptor Type, B (PTPRB) interaction partners

  1. PTPRB regulates branching morphogenesis in the mammary epithelium by modulating the response of the FGFR (show FGFR2 Proteins) signalling pathway to FGF stimulation

  2. STIM1 (show STIM1 Proteins)-induced Ca(2 (show CA2 Proteins)+) signaling activates Pyk2 (show PTK2B Proteins) to inhibit the interaction of VE-PTP and VE-cadherin (show CDH5 Proteins) and hence increase endothelial permeability.

  3. In the absence of Tie-2 (show TEK Proteins), VE-PTP inhibition destabilizes endothelial barrier integrity in agreement with the VE-cadherin (show CDH5 Proteins)-supportive effect of VE-PTP.

  4. The Lewis X (show FUT4 Proteins) epitope is mainly expressed on phosphacan (show PTPRZ1 Proteins)/receptor protein tyrosine phosphatase (show PTPRT Proteins) beta (RPTPbeta) in the developing mouse brain.

  5. VE-PTP activates TIE2 (show TEK Proteins) and stabilizes retinal and choroidal blood vessels

  6. We suggest that lymphocyte binding to vascular cell adhesion molecule 1 (show VCAM1 Proteins) triggers a signaling process that enables a VE-PTP substrate to dissociate VE-PTP from VE-cadherin (show CDH5 Proteins), thereby facilitating efficient transmigration.

  7. We conclude that the role of Tie2 (show TEK Proteins) in maintenance of vascular quiescence involves VE-PTP-dependent dephosphorylation of VEGF receptor-2, and that VEGF receptor-2 activity regulates VE-cadherin (show CDH5 Proteins) tyrosine phosphorylation, endothelial cell polarity

  8. IGFBP-2 bound receptor protein tyrosine phosphatase (show PTPRT Proteins) beta, which led to its dimerization and inactivation. Analysis of aortas obtained from IGFBP-2(-/-) mice showed that receptor protein tyrosine phosphatase (show PTPRT Proteins) beta was activated.

  9. Suggest that VE-PTP, in cooperation with integrins, regulates the spreading and migration of endothelial cells during angiogenesis.

  10. Data show that vascular endothelial protein tyrosine phosphatase (VE-PTP) is a transmembrane binding partner of VE-cadherin (show CDH5 Proteins) that reduces the tyrosine phosphorylation of VE-cadherin (show CDH5 Proteins) and cell layer permeability.

PTPRB Protein Profile

Protein Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PTPRB

  • protein tyrosine phosphatase, receptor type B (PTPRB)
  • receptor-type tyrosine-protein phosphatase beta (LOC100380677)
  • protein tyrosine phosphatase, receptor type, B (Ptprb)
  • protein tyrosine phosphatase, receptor type B (Ptprb)
  • 3230402H02Rik protein
  • C130094E24 protein
  • HPTP-BETA protein
  • HPTPB protein
  • PTPB protein
  • PTPRB protein
  • Ptpz protein
  • R-PTP-BETA protein
  • Rptpb protein
  • VE-PTP protein
  • Veptp protein

Protein level used designations for PTPRB

protein tyrosine phosphatase, receptor type, B , Receptor-type tyrosine-protein phosphatase beta , receptor-type tyrosine-protein phosphatase beta-like , receptor-type tyrosine-protein phosphatase beta , VE-PTP , protein tyrosine phosphatase, receptor type, beta polypeptide , vascular endothelial protein tyrosine phosphatase , R-PTP-beta , protein-tyrosine phosphatase beta

GENE ID SPECIES
718564 Macaca mulatta
100063580 Equus caballus
100380677 Salmo salar
100456419 Pongo abelii
100548729 Meleagris gallopavo
100582561 Nomascus leucogenys
314843 Rattus norvegicus
5787 Homo sapiens
19263 Mus musculus
100350989 Oryctolagus cuniculus
100720273 Cavia porcellus
100156181 Sus scrofa
481162 Canis lupus familiaris
505696 Bos taurus
417853 Gallus gallus
101121760 Ovis aries
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