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The protein encoded by PTPRG is a member of the protein tyrosine phosphatase (PTP) family. Additionally we are shipping PTPRG Antibodies (38) and PTPRG Kits (5) and many more products for this protein.
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Co-localization experiments performed with both anti-PTPRG antibodies identified the presence of isoforms and confirmed protein downregulation at diagnosis in the Philadelphia-positive myeloid lineage (including CD34 (show CD34 Proteins)+/CD38bright/dim cells).
family-based GWAS of imputed SNPs revealed novel genomic variants in (or near) PTPRG, OSBPL6 (show OSBPL6 Proteins), and PDCL3 (show PDCL3 Proteins) that influence risk for Alzheimer's Disease. rs7609954 in the gene PTPRG, rs1347297 in the gene OSBPL6 (show OSBPL6 Proteins), and rs1513625 near PDCL3 (show PDCL3 Proteins). In addition, rs72953347 in OSBPL6 (show OSBPL6 Proteins) and two SNPs in the gene CDKAL1 (show CDKAL1 Proteins) showed marginally significant association with LOAD (rs10456232, P-value=4.76 x 10-7; rs62400067, P-value=3.54 x 10-7).
Results demonstrate that PTPRG plasmatic form (sPTPRG) represent a novel candidate protein biomarker in plasma whose increased expression is associated to hepatocyte damage.
Our results showed that there was no significant association between any of five reported SNPs of TCF4 (show TCF4 Proteins) and PTPRG genes and the occurrence of Fuchs' endothelial dystrophy; only rs7640737 in PTPRG showed an increased risk for corneal dystrophy.
SNPs in PTPRG were not associated with FCD in Caucasians.
PTPRG is a JAK2 (show JAK2 Proteins) phosphatase that negatively regulates leukocyte integrin beta2 activation.
Mutations in PDGFRB (show PDGFRB Proteins) cause infantile myofibromatosis while a mutation in PTPRG may act as an aggravating factor.
Germline polymorphisms in PTPRG gene is associated with lung adenocarcinoma.
PTPRG expression induces dephosphorylation of ERK, a downstream RAS target that may be critical for mutant RAS-induced cell growth.
found that the RPTP-gamma, RPTP-gamma(V948I, S970T) and RPTP-gamma(C858S, S970T) proteins could be stored at 193 K in their respective crystallization buffers without affecting crystallization or crystal quality
vasoconstriction promoted through RPTPgamma-dependent changes in VSMC Ca(2 (show CA2 Proteins)+)-sensitivity
Protein-tyrosine phosphatase receptor type G (RPTPgamma/PTPRG) interacts in vitro with contactin-3-6 (CNTN3-6), a group of glycophosphatidylinositol-anchored cell adhesion molecules involved in the wiring of the nervous system
confirm previous findings and enrich the current knowledge of RPTPgamma distribution in the CNS, highlighting a role of RPTPgamma during neuroinflammation processes
RPTPgamma is expressed in a variety of tissues during embryogenesis.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.
, protein tyrosine phosphatase gamma
, protein tyrosine phosphatase, receptor type, gamma polypeptide
, protein-tyrosine phosphatase gamma
, receptor type protein tyrosine phosphatase gamma
, receptor tyrosine phosphatase gamma
, receptor-type protein phosphatase gamma
, receptor-type tyrosine-protein phosphatase gamma
, Protein-tyrosine phosphatase gamma precursor (R-PTP-gamma)
, RPTP gamma A
, RPTP gamma B
, RPTP gamma C
, RPTP gamma S
, receptor-like protein tyrosine phosphatase gamma