Protein tyrosine Phosphatase, Receptor Type, G Proteins (PTPRG)

The protein encoded by PTPRG is a member of the protein tyrosine phosphatase (PTP) family. Additionally we are shipping PTPRG Antibodies (38) and PTPRG Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTPRG 5793 P23470
PTPRG 19270 Q05909
Rat PTPRG PTPRG 171357  
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Top PTPRG Proteins at antibodies-online.com

Showing 4 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Log in to see 15 to 18 Days
$698.00
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PTPRG Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)
,

More Proteins for Protein tyrosine Phosphatase, Receptor Type, G (PTPRG) Interaction Partners

Human Protein tyrosine Phosphatase, Receptor Type, G (PTPRG) interaction partners

  1. Co-localization experiments performed with both anti-PTPRG antibodies identified the presence of isoforms and confirmed protein downregulation at diagnosis in the Philadelphia-positive myeloid lineage (including CD34 (show CD34 Proteins)+/CD38bright/dim cells).

  2. family-based GWAS of imputed SNPs revealed novel genomic variants in (or near) PTPRG, OSBPL6 (show OSBPL6 Proteins), and PDCL3 (show PDCL3 Proteins) that influence risk for Alzheimer's Disease. rs7609954 in the gene PTPRG, rs1347297 in the gene OSBPL6 (show OSBPL6 Proteins), and rs1513625 near PDCL3 (show PDCL3 Proteins). In addition, rs72953347 in OSBPL6 (show OSBPL6 Proteins) and two SNPs in the gene CDKAL1 (show CDKAL1 Proteins) showed marginally significant association with LOAD (rs10456232, P-value=4.76 x 10-7; rs62400067, P-value=3.54 x 10-7).

  3. Results demonstrate that PTPRG plasmatic form (sPTPRG) represent a novel candidate protein biomarker in plasma whose increased expression is associated to hepatocyte damage.

  4. Our results showed that there was no significant association between any of five reported SNPs of TCF4 (show TCF4 Proteins) and PTPRG genes and the occurrence of Fuchs' endothelial dystrophy; only rs7640737 in PTPRG showed an increased risk for corneal dystrophy.

  5. SNPs in PTPRG were not associated with FCD in Caucasians.

  6. PTPRG is a JAK2 (show JAK2 Proteins) phosphatase that negatively regulates leukocyte integrin beta2 activation.

  7. Mutations in PDGFRB (show PDGFRB Proteins) cause infantile myofibromatosis while a mutation in PTPRG may act as an aggravating factor.

  8. Germline polymorphisms in PTPRG gene is associated with lung adenocarcinoma.

  9. PTPRG expression induces dephosphorylation of ERK, a downstream RAS target that may be critical for mutant RAS-induced cell growth.

  10. found that the RPTP-gamma, RPTP-gamma(V948I, S970T) and RPTP-gamma(C858S, S970T) proteins could be stored at 193 K in their respective crystallization buffers without affecting crystallization or crystal quality

Mouse (Murine) Protein tyrosine Phosphatase, Receptor Type, G (PTPRG) interaction partners

  1. vasoconstriction promoted through RPTPgamma-dependent changes in VSMC Ca(2 (show CA2 Proteins)+)-sensitivity

  2. Protein-tyrosine phosphatase receptor type G (RPTPgamma/PTPRG) interacts in vitro with contactin-3-6 (CNTN3-6), a group of glycophosphatidylinositol-anchored cell adhesion molecules involved in the wiring of the nervous system

  3. Results demonstrate that PTPRG plasmatic form (sPTPRG) represent a novel candidate protein biomarker in plasma whose increased expression is associated to hepatocyte damage.

  4. confirm previous findings and enrich the current knowledge of RPTPgamma distribution in the CNS, highlighting a role of RPTPgamma during neuroinflammation processes

  5. RPTPgamma is expressed in a variety of tissues during embryogenesis.

PTPRG Protein Profile

Protein Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.

Gene names and symbols associated with PTPRG

  • protein tyrosine phosphatase, receptor type G (PTPRG)
  • protein tyrosine phosphatase, receptor type, G (Ptprg)
  • 5430405N12Rik protein
  • AW046354 protein
  • AW549872 protein
  • HPTPG protein
  • Ptpg protein
  • R-PTP-GAMMA protein
  • RPTPG protein
  • RPTPgamma protein

Protein level used designations for PTPRG

H_RG317H01.1 , protein tyrosine phosphatase gamma , protein tyrosine phosphatase, receptor type, gamma polypeptide , protein-tyrosine phosphatase gamma , receptor type protein tyrosine phosphatase gamma , receptor tyrosine phosphatase gamma , receptor-type protein phosphatase gamma , receptor-type tyrosine-protein phosphatase gamma , Protein-tyrosine phosphatase gamma precursor (R-PTP-gamma) , R-PTP-gamma , RPTP gamma A , RPTP gamma B , RPTP gamma C , RPTP gamma S , receptor-like protein tyrosine phosphatase gamma

GENE ID SPECIES
5793 Homo sapiens
19270 Mus musculus
374208 Gallus gallus
171357 Rattus norvegicus
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