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Responsible for the dehydration step in very long-chain fatty acids (VLCFAs) synthesis. Additionally we are shipping Protein tyrosine Phosphatase-Like A Domain Containing 1 Antibodies (31) and many more products for this protein.
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HACD3 (PTPLAD1) is a new candidate gene for type-2 diabetes risk. HACD3 deletion decreases the autophosphorylation of insulin receptor in vitro. HACD3 may regulate the activity of CDK2 and RAB5C.Overexpression of HACD3 inhibits the tyrosine phosphorylation of CDK2 and RAB5C. HACD3 stimulates the physical association of insulin receptor with RAB11A and may regulate the recycling of insulin receptor to the plasma membrane.
Our results indicate that PTPLAD1 (HACD3) is in complex with insulin receptor (IR) in rat's liver and in human HEK293 cells. SiRNA-mediated partial knockdown of PTPLAD1 increased level of IR tyrosine phosphorylation and affect IR endocytosis. PTPLAD1 depletion strongly enhanced insulin effect on Glut2 translocation in HEK293 cells similar to the increase in AKT-ser473 phosphorylation. [PTPLAD1]
Genes in the erythroid differentiation and cell cycle regulation pathways influence interindividual variation in RBC indices. Our results provide insights into the molecular basis underlying variation in RBC traits.
The structure of the B-IND1 gene promoter region was determined.
results suggest that hB-ind1 plays a crucial role in HCV RNA replication and the propagation of JFH1 virus through interaction with viral and host proteins
These results suggest that an Hsp90-dependent chaperone pathway incorporating hB-ind1 is involved in protein folding in the membranous web for the circumvention of the UPR and that it facilitates HCV replication
Responsible for the dehydration step in very long-chain fatty acids (VLCFAs) synthesis. Involved in Rac1-signaling pathways leading to the modulation of gene expression.
3-hydroxyacyl-CoA dehydratase 3
, butyrate-induced protein 1
, butyrate-induced transcript 1
, protein tyrosine phosphatase-like protein PTPLAD1
, protein-tyrosine phosphatase-like A domain-containing protein 1
, very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3
, 3-hydroxyacyl-CoA dehydratase
, very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase
, Protein tyrosine phosphatase-like protein PTPLAD1