anti-Proteolipid Protein 1 (PLP1) Antibodies

PLP1 encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. Additionally we are shipping Proteolipid Protein 1 Kits (43) and Proteolipid Protein 1 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PLP1 5354 P60201
PLP1 24943 P60203
PLP1 18823 P60202
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Top anti-Proteolipid Protein 1 Antibodies at antibodies-online.com

Showing 10 out of 68 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-PLP1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  721_B cell lysate Immunohistochemistry with Brain, cerebellum tissue at an antibody concentration of 5µg/ml using anti-PLP1 antibody (ARP33843_P050) 100 μL Log in to see 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PLP1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Hela cell lysate Host:  Mouse  Target Name:  PLP1  Sample Tissue:  Mouse Heart  Antibody Dilution:  1ug/ml 100 μL Log in to see 2 to 3 Days
$319.00
Details
Cow Mouse Un-conjugated FACS, IHC (fro), IF, IHC (p), WB   0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of Myelin PLP expression in rat brain extract ( Lane 1), mouse brain extract ( Lane 2) and SHG-44 whole cell lysates ( Lane 3). Myelin PLP at 34KD was detected using rabbit anti- Myelin PLP Antigen Affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). 100 μg Log in to see 4 to 6 Days
$240.00
Details
Mouse Rabbit Un-conjugated ICC, WB Western Blot: Myelin PLP Antibody [ABIN2615973] - Analysis of adult mouse brain samples. 0.1 mL Log in to see 7 to 9 Days
$446.35
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: Myelin PLP Antibody [NBP1-87781] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY400181) Immunohistochemistry-Paraffin: Myelin PLP Antibody [NBP1-87781] - Border of a demyelinated lesion. Image from verified customer review. 0.1 mL Log in to see 7 to 9 Days
$494.38
Details
Human Rabbit Un-conjugated IP, WB PLP1 MaxPab rabbit polyclonal antibody. Western Blot analysis of PLP1 expression in mouse testis. PLP1 MaxPab rabbit polyclonal antibody. Western Blot analysis of PLP1 expression in A-431. 100 μL Log in to see 11 to 12 Days
$425.71
Details
Cow Mouse Un-conjugated IHC, IHC (fro), IHC (p), WB Human Brain, Cerebellum (formalin-fixed, paraffin-embedded) stained with PLP1 antibody ABIN364261 at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with PLP1 antibody ABIN364261 at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. 0.05 mg Log in to see 11 to 14 Days
$484.00
Details
Human Mouse Un-conjugated ICC, IHC, IHC (fro), IHC (p), WB Anti-PLP1 antibody IHC staining of human brain cerebellum, neuropil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1103681 dilution 10 ug/ml. Anti-PLP1 antibody IHC of human brain cerebellum, neuropil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml. 50 μg Log in to see 11 to 14 Days
$727.83
Details
Human Chicken Un-conjugated ICC, IF, IHC (p), IHC, WB In this tissue section through an e 13 mouse brain, PLP (green staining) can be seen in immature oligodendrocytes of white matter tracts. DAPI (blue staining) allows visualization of nuclei. 0.25 mL Log in to see 7 to 9 Days
$418.10
Details

Top referenced anti-Proteolipid Protein 1 Antibodies

  1. Cow (Bovine) Monoclonal PLP1 Primary Antibody for IHC (fro), FACS - ABIN2475779 : Ballard: Retrospective studies of left atrial thrombus: does misclassification impair their clinical utility? in Journal of general internal medicine 1991 (PubMed)
    Show all 4 Pubmed References

  2. Mouse (Murine) Polyclonal PLP1 Primary Antibody for ICC, WB - ABIN261597 : Horiuchi, Maezawa, Itoh, Wakayama, Jin, Itoh, Decarli: Amyloid β1-42 oligomer inhibits myelin sheet formation in vitro. in Neurobiology of aging 2012 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal PLP1 Primary Antibody for ICC, IF - ABIN151155 : Cachón-González, Wang, Ziegler, Cheng, Cox: Reversibility of neuropathology in Tay-Sachs-related diseases. in Human molecular genetics 2014 (PubMed)

  4. Human Polyclonal PLP1 Primary Antibody for IHC, IHC (p) - ABIN4337000 : Li, Tsuneki, Krauthammer, Couture, Schwartz, Madri: Modulation of Sox10, HIF-1?, Survivin, and YAP by Minocycline in the Treatment of Neurodevelopmental Handicaps following Hypoxic Insult. in The American journal of pathology 2015 (PubMed)

More Antibodies against Proteolipid Protein 1 Interaction Partners

Human Proteolipid Protein 1 (PLP1) interaction partners

  1. PLP1 mutation is associated with hereditary spastic paraplegia.

  2. Findings suggest that PLP1 and CNTN1 gene variations modulate specific aspects of callosal microstructure that are in line with their gene function.

  3. three single nucleotide polymorphisms in PLP1 that were associated with interhemispheric integration via the corpus callosum in a previous study also are relevant for functional hemispheric asymmetries.

  4. This study demonstrated that the plp and alpha-synuclein transgenic mouse model of multiple system atrophy showed the Progressive striatonigral degeneration.

  5. Pelizaeus-Merzbacher disease (PMD) is an X-linked disorder caused by mutations in the PLP1 gene, which encodes the proteolipid protein of myelinating oligodendroglia.

  6. Proteolipid protein 1 and contactin 1 gene variation modulates interhemispheric integration

  7. Using whole exome sequencing, a novel pathogenic PLP1 missense mutation c.251C > A (p.Ala84Asp) was detected in a Moroccan family, allowing a diagnosis of Pelizaeus-Merzbacher Disease.

  8. down-regulated in cord blood by prenatal smoking

  9. Authors investigated the disease progression in mouse models carrying PLP1 point mutations previously found in patients displaying clinical features of multiple sclerosis. These mouse models show loss-of-function of PLP1 associated with neuroinflammation.

  10. Review focusing on sequences in hPLP1 intron 1 DNA deemed important for hPLP1 gene activity as well as a couple of "human-specific" supplementary exons within the first intron which are utilized to generate novel splice variants, and the potential role that these sequences may play in PLP1-linked disorders.

  11. it seems that the epitopes of some microorganisms mimicking PLP such as PLP58-74 might have a potential role in the initiation of Multiple Sclerosis.

  12. Human induced pluripotent stem cells-derived oligodendrocytes from 12 individuals with Pelizaeus-Merzbacher and identified individual and shared defects in PLP1 mRNA expression and splicing, oligodendrocyte progenitor development, and oligodendrocyte morphology and capacity for myelination.

  13. report a novel mutation of the PLP1 gene in two siblings with Pelizaeus-Merzbacher disease associated with a rare and protean neuroimaging finding of optic nerve enlargement

  14. Identification and functional study of novel PLP1 mutations in Chinese patients with Pelizaeus-Merzbacher disease. We identified PLP1 mutations in seven male patients with PMD.

  15. In major depressive disorder there was a significantly reduced expression of PLP1 mRNA.

  16. Study investigated 17 unrelated Pelizaeus-Merzbacher disease subjects with copy number gains at the PLP1 locus including triplication and quadruplication of specific genomic intervals-16/17 were found to have a duplication-inverted triplication-duplication rearrangement product.

  17. Myelin proteolipid protein is critical to regulating oligodendrocyte progenitor cell migration.

  18. PLP1 splicing mutations may result in a wide variety of disease phenotypes through a combination of multiple molecular pathogenic mechanisms.

  19. this study provides new insight into the genotype-phenotype correlations of patients with PLP1 splice-site mutations.

  20. Insertion of an extra copy of Xq22.2 into 1p36 results in functional duplication of the PLP1 gene in a girl with classical Pelizaeus-Merzbacher disease.

Mouse (Murine) Proteolipid Protein 1 (PLP1) interaction partners

  1. These results suggest that colitis promotes rapid enteric neurogenesis in adult mice and humans through differentiation of Sox2- and PLP1-expressing cells, which represent enteric glia and/or neural progenitors

  2. This study demonstrated that Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2.

  3. The rumpshaker missense mutation in the Plp1 gene gives rise to subcortical myoclonus

  4. axonal mitochondria, smooth endoplasmic reticulum, and microtubules were characterized in rodent optic nerves where PLP is replaced by the peripheral nerve myelin protein, P0.

  5. The observations collectively support the idea that GST-pi(Nuc)/DM-20 mRNA-expressing cells are the progeny of NG2-positive OPCs rather than a novel type of oligodendrocyte-lineage progenitor cells and that DM-20 mRNA expression is dynamically regulated during differentiation of OPCs into oligodendrocytes.

  6. In the absence of P0, thus, PLP also contributes to myelination by Schwann cells and to the preservation of peripheral axons

  7. while PLP can co-exist with P0 in peripheral nervous system(PNS) myelin, PLP cannot replace P0 as the major structural protein of PNS myelin.

  8. Both extracellular and intracellular epitopes of PLP contribute to the pathogenesis of MP4-induced experimental autoimmune encephalomyelitis already in the setting of intact myelin.

  9. The insertion of native PLP into Olg mitochondria of animals with PLP1/Plp1 regulates extracellular pH and adenosine triphosphate.

  10. This study shows for the first time that Plp-null mice exhibit severe early-onset thermal hyperalgesia that is not associated with changes in thermal allodynic behavior.

  11. A novel mechanism sheds light on the immune regulation by which sulfatide-reactive type II natural killer (NK)T cells suppress inflammatory class II histocompatibility-restricted pathogenic CD4+ T cell responses in a T cell-mediated autoimmune disease.

  12. that an early reactive glia response occurs following mutations in the PLP gene

  13. Result suggest that plp1 plays a role either in the structural integrity of oligodendrocyte progenitor cell processes or in their response to extracellular cues that orient process outgrowth.

  14. PLP significantly suppresses both models of experimental autoimmune encephalitis (EAE)even when there is some evidence of epitope spreading in the myelin oligodendrocyte (MOG)38-50-induced EAE model.

  15. PLP contributes to the high cholesterol content of myelin by association and co-transport in the central nervous system.

  16. Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum.

  17. PLP1 mutants inhibit Golgi apparatus to endoplasmic reticulum trafficking and have a role in pathogenesis of Pelizaeus-Merzbacher disease

  18. The results presented here suggest that the antisilencer/enhancer is largely dispensable for the developmental regulation of Plp1 gene expression in vivo.

  19. Our data indicate that miR-20a, a component of the cluster that controls oligodendrocyte cell number, regulates myelin proteolipid protein gene expression

  20. PLP gene expression is evident in both neuronal and oligodendroglial phenotypes in developing neostriatum.

Proteolipid Protein 1 (PLP1) Antigen Profile

Protein Summary

This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.

Gene names and symbols associated with PLP1

  • proteolipid protein 1 (PLP1) antibody
  • proteolipid protein 1 (Plp1) antibody
  • proteolipid protein 1 (plp1) antibody
  • proteolipid protein (myelin) 1 (Plp1) antibody
  • myelin proteolipid protein (Tsp_11640) antibody
  • myelin proteolipid protein (plp) antibody
  • proteolipid protein 1 L homeolog (plp1.L) antibody
  • proteolipid protein 1a (plp1a) antibody
  • DKFZp459O081 antibody
  • DKFZp459O113 antibody
  • DM20 antibody
  • DMalpha2c antibody
  • GPM6C antibody
  • hld1 antibody
  • jimpy antibody
  • jp antibody
  • mmpl antibody
  • msd antibody
  • plp antibody
  • PLP/DM20 antibody
  • plp1 antibody
  • plp1a antibody
  • pmd antibody
  • rsh antibody
  • spg2 antibody
  • wu:fc27f01 antibody
  • wu:fj36d03 antibody
  • wu:fj42d08 antibody
  • zgc:110499 antibody

Protein level used designations for PLP1

lipophilin , major myelin proteolipid protein , myelin proteolipid protein , Proteolipid protein (Pelizaeus-Merzbacher disease spastic paraplegia 2 uncomplicated) , Proteolipid protein (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated) , proteolipid protein (myelin) 1 , proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated) , proteolipid protein, lipophilin , proteolipid protein 1 , myelin synthesis deficiency , rump shaker , PLP , PLP-A , lipophilin-A , myelin proteolipid protein (PLP) , myelin proteolipid protein A , proteolipid protein 1 a , DMalpha1 , etID60288.14

GENE ID SPECIES
5354 Homo sapiens
24943 Rattus norvegicus
281410 Bos taurus
397029 Sus scrofa
465785 Pan troglodytes
481002 Canis lupus familiaris
613099 Xenopus (Silurana) tropicalis
100009169 Oryctolagus cuniculus
100173486 Pongo abelii
100174736 Pongo abelii
18823 Mus musculus
396214 Gallus gallus
10903177 Trichinella spiralis
100136749 Oncorhynchus mykiss
398334 Xenopus laevis
100220245 Taeniopygia guttata
64264 Danio rerio
100714212 Cavia porcellus
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