anti-Pterin-4 alpha-Carbinolamine Dehydratase/dimerization Cofactor of Hepatocyte Nuclear Factor 1 alpha (PCBD1) Antibodies

PCBD1 encodes pterin-4 alpha-carbinolamine dehydratase, an enzyme involved in phenylalanine hydroxylation. Additionally we are shipping PCBD1 Proteins (16) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PCBD1 13180 P61458
PCBD1 5092 P61457
PCBD1 29700 P61459
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Top anti-PCBD1 Antibodies at antibodies-online.com

Showing 10 out of 56 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PCBD1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: Human heart 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Pcbd1 Antibody Titration: 1.0 ug/ml Positive Control: Mouse Brain 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB PCBD1 Antibody (Center) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with PCBD1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. 0.4 mL 6 to 8 Days
$484.00
Details
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
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Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
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Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated IC, IF, WB Immunofluorescent analysis of PCBD1 staining in U2OS cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody Western blot analysis of PCBD1 expression in SW620 (A), mouse kidney (B), mouse pancreas (C), rat liver (D) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL 2 to 3 Days
$446.88
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL 2 to 3 Days
$446.88
Details
Human Rabbit Un-conjugated IF/ICC, WB Western blot analysis of extracts of various cell lines, using PCBD1 antibody (ABIN5973794) at 1/1000 dilution. Immunofluorescence analysis of U2OS cells using PCBD1 antibody (ABIN5973794). Blue: DAPI for nuclear staining. 100 μL 11 to 16 Days
$426.40
Details

More Antibodies against PCBD1 Interaction Partners

Mouse (Murine) Pterin-4 alpha-Carbinolamine Dehydratase/dimerization Cofactor of Hepatocyte Nuclear Factor 1 alpha (PCBD1) interaction partners

  1. DCoH acts as a cofactor for HNF1 that stabilizes the dimeric HNF1 complex.

  2. HNF1alpha binding kinetics may distinguish regulation by DCoH2, under thermodynamic control, from regulation by DCoH, under kinetic control

Human Pterin-4 alpha-Carbinolamine Dehydratase/dimerization Cofactor of Hepatocyte Nuclear Factor 1 alpha (PCBD1) interaction partners

  1. We provide the first genetic evidence that PCBD1 mutations can cause early-onset nonautoimmune diabetes with features similar to dominantly inherited HNF1A-diabetes.

  2. Coactivator of the HNFB1 (HNF1 homeobox B)-mediated transcription is necessary for fine tuning ATPase Na+/K+ transporting gamma 1 polypeptide (FXYD2) transcription in the distal convoluted tubule

  3. Pcbd1 is a moonlighting protein that has dehydratase activity in addition to functioning as a cofactor which regulates HNF1alpha.

  4. variants of the hepatocyte nuclear factor-1beta (HNF-1beta / TCF2) and the dimerization cofactor of HNF-1 (DcoH/PCBD) genes in relation to type 2 diabetes mellitus and beta-cell function

  5. Data reveal DCoH/HNF-1 alpha expression and transcriptional activity in human epidermal melanocytes in vitro and in situ and identified tyrosinase, the key enzyme for pigmentation, as a new transcriptional target.

  6. Albumin colocalized together with its transcription factor PCD/DCoH/HNF-1alpha in suprabasal keratinocytes in human full-thickness skin sections and in keratinocytes cultured in serum-free medium.

  7. Properties of dehydratase/DCoHalpha are consistent with hypothesis that activity of this isozyme could account for relatively mild symptoms reported for patients with a defect in dehydratase/DCoH

PCBD1 Antigen Profile

Protein Summary

This gene encodes pterin-4 alpha-carbinolamine dehydratase, an enzyme involved in phenylalanine hydroxylation. A deficiency of this enzyme leads to hyperphenylalaninemia. The enzyme regulates the homodimerization of the transcription factor hepatocyte nuclear factor 1 (HNF1).

Gene names and symbols associated with PCBD1

  • pterin-4a-carbinolamine dehydratase (Pcd) antibody
  • pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (pcbd1) antibody
  • pterin-4-alpha-carbinolamine dehydratase (Tb11.02.4890) antibody
  • pterin-4-alpha-carbinolamine dehydratase (pcbd) antibody
  • pterin-4-alpha-carbinolamine dehydratase (Fbal_2579) antibody
  • pterin-4-alpha-carbinolamine dehydratase (Ftrac_2004) antibody
  • pterin-4-alpha-carbinolamine dehydratase (Celal_2911) antibody
  • pterin-4-alpha-carbinolamine dehydratase (Isop_1133) antibody
  • pterin-4-alpha-carbinolamine dehydratase (Celly_0291) antibody
  • pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1 (Pcbd1) antibody
  • pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha L homeolog (pcbd1.L) antibody
  • pterin-4 alpha-carbinolamine dehydratase 1 (PCBD1) antibody
  • pterin-4 alpha-carbinolamine dehydratase 1 (Pcbd1) antibody
  • BcDNA:LP07248 antibody
  • CG1963 antibody
  • DCoH antibody
  • DDBDRAFT_0204977 antibody
  • DDBDRAFT_0305045 antibody
  • DDB_0204977 antibody
  • DDB_0305045 antibody
  • Dmel\\CG1963 antibody
  • PCBD antibody
  • pcd antibody
  • PHS antibody
  • TCF1 antibody
  • Xdcoh antibody
  • zgc:73389 antibody

Protein level used designations for PCBD1

CG1963-PA , Pcd-PA , pterin-4-alpha-carbinolamine dehydratase , 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) , 4-alpha-hydroxy-tetrahydropterin dehydratase , PCD , PHS , dimerization cofactor of HNF1 , dimerization cofactor of hepatocyte nuclear factor 1-alpha , dimerization cofactor of hepatocyte nuclear factor-1-alpha , phenylalanine hydroxylase-stimulating protein , pterin carbinolamine dehydratase , DCoH , XDCoH , 6-pyruvoyl-tetrahydropterin synthase , cDcoH , pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) , dimerizing cofactor for HNF1 , pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1

GENE ID SPECIES
43499 Drosophila melanogaster
393787 Danio rerio
496425 Xenopus (Silurana) tropicalis
3665797 Trypanosoma brucei brucei strain 927/4 GUTat10.1
8623790 Dictyostelium discoideum AX4
9771410 Ferrimonas balearica DSM 9799
10012150 Marivirga tractuosa DSM 4126
10145334 Cellulophaga algicola DSM 14237
10155246 Isosphaera pallida ATCC 43644
10262275 Cellulophaga lytica DSM 7489
13180 Mus musculus
397951 Xenopus laevis
395729 Gallus gallus
5092 Homo sapiens
530736 Bos taurus
29700 Rattus norvegicus
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