anti-Purinergic Receptor P2Y, G-Protein Coupled, 8 (P2RY8) Antibodies

Human Purinergic Receptor P2Y, G-Protein Coupled, 8 (P2RY8) interaction partners

1. S-Geranylgeranyl-L-glutathione(GGG) is identified as an intercellular signalling molecule that is involved in organizing and controlling germinal-centre responses; as the P2RY8 locus is modified in several other types of cancer in addition to GCB-DLBCL and Burkitt lymphoma, GGG might have organizing and growth-regulatory roles in multiple human tissues

2. P2RY8-CRLF2 fusion is associated with childhood B-cell acute lymphoblastic leukemia.

3. P2RY8 promotes clustering of activated B cells within follicles in a follicular dendritic cell (FDC)-dependent manner.

4. P2RY8-CRLF2-positive clones do not have the necessary proliferative or selective advantage to evolve into a disease-relevant relapse clone.

5. Poor prognosis for P2RY8-CRLF2 fusion but not for CRLF2 over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemia.

6. Study reports an extremely high incidence of relapse (71% +/- 19%) in non-high-risk precursor B-cell acute lymphoblastic leukemia patients with P2RY8-CRLF2 rearrangement.

7. P2RY8 is expressed in leukemic cells and has an unexpected role in the pathogenesis of acute leukemia

8. SOX5 is upregulated by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma