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The protein encoded by P2RY8 belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides.
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P2RY8-CRLF2 fusion (show CRLF2 Antibodies) is associated with childhood B-cell acute lymphoblastic leukemia.
P2RY8 promotes clustering of activated B cells within follicles in a follicular dendritic cell (FDC)-dependent manner.
P2RY8-CRLF2 (show CRLF2 Antibodies)-positive clones do not have the necessary proliferative or selective advantage to evolve into a disease-relevant relapse clone.
Poor prognosis for P2RY8-CRLF2 fusion (show CRLF2 Antibodies) but not for CRLF2 (show CRLF2 Antibodies) over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemia.
Study reports an extremely high incidence of relapse (71% +/- 19%) in non-high-risk precursor B-cell acute lymphoblastic leukemia patients with P2RY8-CRLF2 (show CRLF2 Antibodies) rearrangement.
P2RY8 is expressed in leukemic cells and has an unexpected role in the pathogenesis of acute leukemia
SOX5 (show SOX5 Antibodies) is upregulated by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y.
P2Y purinoceptor 8
, G-protein coupled purinergic receptor P2Y8