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Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. Additionally we are shipping PDXP Antibodies (28) and PDXP Proteins (9) and many more products for this protein.
Showing 10 out of 21 products:
Chronophin has a role in coordinating cell leading edge dynamics by controlling active cofilin (show CFL1 ELISA Kits) levels
Splicing of SH3BP1 and CIN gene loci produces the novel brain specific splice variant BGIN.
analysis of pyridoxal phosphatase cloning, expression and tissue distribution
We report the biochemical isolation of chronophin (CIN), a unique cofilin (show CFL1 ELISA Kits)-activating phosphatase of the haloacid dehalogenase (HAD) superfamily and an important novel regulator of cofilin (show CFL1 ELISA Kits)-mediated actin reorganization.
Results suggest that the transduction of the PEP-1-PLPP fusion protein can be one mode of PLP (show PLP1 ELISA Kits) level regulation, and to replenish this enzyme in the various neurological disorders related to vitamin B(6).
Study demonstrates the ATP-sensitive interaction of the cofilin (show CFL1 ELISA Kits) phosphatase chronophin (CIN) with the chaperone hsp90 (show HSP90 ELISA Kits) to form a biosensor that mediates cofilin (show CFL1 ELISA Kits)/actin rod formation.
Results provided novel evidence that PLPP is involved in controlling dendritic spine as well as synaptic plasticity. It showed also for the first time the role of PLPP in GluN functionality via regulation of GluN2A (show GRIN2A ELISA Kits) interaction with postsynaptic proteins. These findings suggest that PLPP/CIN may play an important role in information storage and recall capacity, which manifests as a learning memory.
Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities.
Dimer formation is essential for an intermolecular arginine-arginine-tryptophan stacking interaction that positions a critical histidine residue in the substrate specificity loop of chronophin for PLP (show C3 ELISA Kits) coordination.
Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al., 2003
, pyridoxal phosphate phosphatase
, pyridoxal phosphatase
, reg I binding protein I
, reg I-binding protein 1