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The protein encoded by PPA1 is a member of the inorganic pyrophosphatase (PPase) family. Additionally we are shipping Pyrophosphatase (Inorganic) 1 Proteins (11) and Pyrophosphatase (Inorganic) 1 Kits (9) and many more products for this protein.
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Proteomic profiling identifies the inorganic pyrophosphatase (PPA1) protein as a potential biomarker of metastasis in laryngeal squamous cell carcinoma.
Results show that PPA1 expression is significantly higher in many tumors, especially those of lung and ovarian origin, which suggests that PPA1 plays an important role in carcinogenesis and in the development of some tumors.
PPA1 serves as a potential prognostic biomarker for patients with Ovarian serous carcinoma.
enhanced NEK2 (show NEK2 Antibodies) expression in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) promotes HCC (show FAM126A Antibodies) progression and drug resistance by promoting PP1/Akt (show AKT1 Antibodies) and Wnt (show WNT2 Antibodies) pathway activation, which may represent a new therapeutic target for HCC (show FAM126A Antibodies).
Thus, the Ska complex, specifically the Ska1 C-terminal domain, recruits PP1 to kinetochores to oppose spindle checkpoint signaling kinases and promote anaphase onset.
PPA1 may serve as a potential biomarker of poor prognosis in patients with gastric cancer
PP-1 and Akt (show AKT1 Antibodies) have roles in AR-v7 protein expression and activities when AR is functionally blocked
The Newcastle disease virus-induced translation shutoff at late infection times was attributed to sustaining phosphorylation of eIF2a, which is mediated by continual activation of PKR and degradation of PP1.
The human PP1 interaction with the measles V protein is mediated by a conserved PP1-binding motif in the C-terminal region of the V protein.
Measles virus binding to DC-SIGN (show CD209 Antibodies) leads to inhibition of PP1 phosphatase activity and hence inhibition of RIG-I (show DDX58 Antibodies) and Mda5 (show IFIH1 Antibodies) dephosphorylation.
PPA1 may play a role in neuronal differentiation via JNK (show MAPK8 Antibodies) dephosphorylation.
IRBIT (show AHCYL1 Antibodies) opposes the effects of WNKs and SPAK (show STK39 Antibodies) by recruiting PP1 (show PPP1CC Antibodies) to the complex to dephosphorylate CFTR (show CFTR Antibodies) and NBCe1 (show SLC4A4 Antibodies)-B, restoring their cell surface expression, in addition to stimulating their activities
The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in bovine suggested a cytoplasmic localization of this enzyme.
, Inorganic pyrophosphatase
, cytosolic inorganic pyrophosphatase
, diphosphate phosphohydrolase
, inorganic diphosphatase
, inorganic pyrophosphatase 1
, pyrophosphatase 1
, pyrophosphate phospho-hydrolase