Pyruvate Dehydrogenase (Lipoamide) alpha 1 Proteins (PDHA1)

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. Additionally we are shipping PDHA1 Antibodies (171) and PDHA1 Kits (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PDHA1 5160 P08559
PDHA1 18597 P35486
PDHA1 29554  
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Top PDHA1 Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Baculovirus infected Insect Cells Human GST tag,His tag 100 μg Log in to see 20 to 21 Days
$437.80
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Yeast Wild boar His tag   1 mg Log in to see 60 to 71 Days
$2,986.50
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,986.50
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Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,986.50
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Yeast Cynomolgus His tag   1 mg Log in to see 60 to 71 Days
$2,986.50
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Yeast Chimpanzee His tag   1 mg Log in to see 60 to 71 Days
$2,986.50
Details

PDHA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) Interaction Partners

Human Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) interaction partners

  1. ATP5G1 (show ATP5G1 Proteins), ATP5G2 (show ATP5G2 Proteins), and ATP5G3 (show ATP5G3 Proteins) of the ATP synthase are not involved in forming the permeability transition pore.

  2. Case demonstrates fetal akinesia deformation sequence due to a de novo hemizygous c.498C > T splice-site mutation in the pyruvate dehydrogenase-alpha 1 (PDHA1) gene.

  3. Data show that metformin reduces hypoxia-inducible factor 1alpha (HIF-1alpha (show HIF1A Proteins)) gene expression and increases pyruvate dehydrogenase (PDH (show PDP Proteins)) expression.

  4. The report PDHA1 as a new component of brainstem-type Lewy bodies in idiopathic PD, DLB and PARK14, the level of PDHA1 protein being significantly decreased in the putamen and substantia nigra of patients with idiopathic Parkinson's disease .

  5. Findings show that serine-threonine-tyrosine kinase 1 (NOK (show STYK1 Proteins)) mediates glycolysis and nuclear pyruvate dehydrogenase (show PDP Proteins) complex (PDC (show PNKD Proteins)) associated histone acetylation.

  6. The association of mitochondrial microphthalmia-associated transcription factor (MITF (show MITF Proteins)) with pyruvate dehydrogenase (PDH (show PDP Proteins)) emerges as an important regulator of mast cell function. Our findings indicate that PDH (show PDP Proteins) could arise as a new target for the manipulation of allergic diseases.

  7. our results show that negative PDHA1 gene expressionis associated with significantly higher cell stemness in prostate cancer cells and reduced protein expression of this gene is associated with shorter clinical outcome in prostate cancers.

  8. ATP5G1 (show ATP5G1 Proteins) turnover increases upon depletion of ZC3H14 (show ZC3H14 Proteins), double knockdown of ZC3H14 (show ZC3H14 Proteins) and the nonsense-mediated decay factor, UPF1 (show UPF1 Proteins), rescues ATP5G1 (show ATP5G1 Proteins) transcript levels. Furthermore, fractionation reveals an increase in the amount of ATP5G1 (show ATP5G1 Proteins) pre-mRNA that reaches the cytoplasm when ZC3H14 (show ZC3H14 Proteins) is depleted and that ZC3H14 (show ZC3H14 Proteins) binds to ATP5G1 (show ATP5G1 Proteins) pre-mRNA in the nucleus.

  9. oncoprotein HBXIP (show HBXIP Proteins) enhances glucose metabolism reprogramming through suppressing SCO2 (show SCO2 Proteins) and PDHA1 in breast cancer

  10. MPO (show MPO Proteins) and BPI (show BPI Proteins) in CD4 (show CD4 Proteins)(+)T-lymphocytes, and PDHA1 and MRPL42 (show MRPL42 Proteins) in CD8 (show CD8A Proteins)(+) T-lymphocytes might be used as specific biomarkers of severe asthma progression.

Mouse (Murine) Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) interaction partners

  1. Cardiac PDH (show PDP Proteins) E1alpha deficiency impairs ischemic AMP-activated protein kinase (show PRKAA2 Proteins) signaling and sensitizes hearts to the toxicological actions of ischemic stress.

  2. Taken together, our results indicate that the redox sensing and ROS (show ROS1 Proteins) forming properties of Pdh (show PDP Proteins) and Ogdh (show alphaKGDHC Proteins) are linked to S-glutathionylation

  3. Systemic Pyruvate Dehydrogenase (show PDP Proteins) Deficiency is associated with Cerebral Developmental Abnormalities.

  4. The association of mitochondrial microphthalmia-associated transcription factor (MITF (show MITF Proteins)) with pyruvate dehydrogenase (PDH (show PDP Proteins)) emerges as an important regulator of mast cell function. Our findings indicate that PDH (show PDP Proteins) could arise as a new target for the manipulation of allergic diseases.

  5. skeletal muscle IL-6 (show IL6 Proteins) contributes to the regulation of PDH (show PDP Proteins) at rest and during prolonged exercise.

  6. The present findings suggest that IL-6 (show IL6 Proteins) contributes to regulating the PDHa activity and hence carbohydrate oxidation, but the metabolic state of the muscle seems to determine the outcome of this regulation

  7. Liver-specific pyruvate dehydrogenase (show PDP Proteins) complex deficiency upregulates lipogenesis in adipose tissue and improves peripheral insulin (show INS Proteins) sensitivity.

  8. PGC-1alpha regulates PDH (show PDP Proteins)-E1alpha protein content in parallel with mitochondrial oxidative proteins, but does not seem to influence PDH (show PDP Proteins) regulation in mouse skeletal muscle in response to fasting and in recovery from exercise.

  9. Embryos carrying predominantly the Pdha1(deletion in exon 8, Deltaex8) allele were found to be globally delayed in development by 9.5 days postcoitus, with resorption occurring over the following several days.

Zebrafish Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) interaction partners

  1. The study provired that pyruvate dehydrogenase (show PDK2 Proteins)-deficient mutant caused the retinal drficits in zebrafish.

PDHA1 Protein Profile

Protein Summary

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding the same protein have been identified.

Gene names and symbols associated with PDHA1

  • pyruvate dehydrogenase E1 alpha 1 subunit (PDHA1)
  • ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) (ATP5G1)
  • pyruvate dehydrogenase E1 alpha 1 (Pdha1)
  • pyruvate dehydrogenase E1 alpha 1 subunit (Pdha1)
  • pyruvate dehydrogenase (lipoamide) alpha 1 (PDHA1)
  • pyruvate dehydrogenase E1 alpha 1 subunit (pdha1)
  • pyruvate dehydrogenase (lipoamide) alpha 1 pseudogene (LOC719277)
  • 2-oxo acid dehydrogenase (VNG_RS07485)
  • pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha (RR_RS04695)
  • pyruvate dehydrogenase alpha subunit protein (pdhA1)
  • pyruvate dehydrogenase (acetyl-transferring) protein, alpha subunit (pdhA1)
  • precursor of dehydrogenase pyruvate dehydrogenase E1 component alpha subunit (PDHA1)
  • pyruvate dehydrogenase (PDHA1)
  • pyruvate dehydrogenase E1 alpha 1 subunit b (pdha1b)
  • pyruvate dehydrogenase (lipoamide) alpha 1 S homeolog (pdha1.S)
  • ATP5A protein
  • ATP5G protein
  • pdha protein
  • Pdha-1 protein
  • Pdha1 protein
  • pdha1-a protein
  • pdha1-b protein
  • pdhce1a protein
  • phe1a protein
  • wu:fp73b04 protein
  • zgc:92705 protein

Protein level used designations for PDHA1

PDHE1-A type I , pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial , pyruvate dehydrogenase complex, E1-alpha polypeptide 1 , ATP synthase lipid-binding protein, mitochondrial , ATP synthase proteolipid P1 , ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9) , ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9) , ATPase protein 9 , ATPase subunit 9 , ATPase subunit C , mitochondrial ATP synthase, subunit 9 , mitochondrial ATP synthase, subunit C , pyruvate dehydrogenase E1alpha subunit , pyruvate dehydrogenase E1 alpha 1 , pyruvate dehydrogenase E1 component alpha subunit , pyruvate dehydrogenase alpha 1 , pyruvate dehydrogenase (lipoamide) alpha 1 , PdhA1 , pyruvate dehydrogenase alpha subunit , pyruvate dehydrogenase E1 component subunit alpha , pyruvate dehydrogenase alpha subunit protein , pyruvate dehydrogenase (acetyl-transferring) protein, alpha subunit , precursor of dehydrogenase pyruvate dehydrogenase E1 component alpha subunit , pyruvate dehydrogenase , Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial , pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial-like , fp73b04 , pyruvate dehydrogenase (lipoamide) alpha 1 S homeolog

GENE ID SPECIES
5160 Homo sapiens
516 Homo sapiens
18597 Mus musculus
29554 Rattus norvegicus
407109 Bos taurus
418610 Gallus gallus
465525 Pan troglodytes
480858 Canis lupus familiaris
549826 Xenopus (Silurana) tropicalis
719277 Macaca mulatta
1448416 Halobacterium sp. NRC-1
3129238 Haloarcula marismortui ATCC 43049
3893971 Rhizobium etli CFN 42
6400117 Rhizobium etli CIAT 652
7195506 Phaeodactylum tricornutum CCAP 1055/1
7369176 Agrobacterium radiobacter K84
7450426 Thalassiosira pseudonana CCMP1335
100174745 Pongo abelii
100294678 Sus scrofa
100357349 Oryctolagus cuniculus
100400144 Callithrix jacchus
100471829 Ailuropoda melanoleuca
100587584 Nomascus leucogenys
436672 Danio rerio
100735725 Cavia porcellus
447434 Xenopus laevis
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