Pyruvate Dehydrogenase Phosphatase Proteins (PDP)

Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Additionally we are shipping Pyruvate Dehydrogenase Phosphatase Antibodies (68) and Pyruvate Dehydrogenase Phosphatase Kits (50) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PDP 54704 Q9P0J1
PDP 381511 Q3UV70
PDP 54705  
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Top Pyruvate Dehydrogenase Phosphatase Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$698.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,314.67
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$3,314.67
Details
Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
Details

PDP Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Pyruvate Dehydrogenase Phosphatase (PDP) Interaction Partners

Human Pyruvate Dehydrogenase Phosphatase (PDP) interaction partners

  1. High PDH expression is associated with glucose intolerance.

  2. YB-1 (show YBX1 Proteins) phosphorylation at Ser (show SIGLEC1 Proteins)-102 is an important prerequisite for CCL5 (show CCL5 Proteins) promoter activation during macrophage differentiation

  3. the pyruvate dehydrogenase complex is regulated by Tyr (show TYR Proteins) phosphorylation of PDP1, which toggles recruitment between ACAT1 (show ACAT1 Proteins) and SIRT3 (show SIRT3 Proteins)

  4. Although 7 days of bed rest induced whole body glucose intolerance, exercise-induced PDH regulation in skeletal muscle was not changed, suggesting that exercise-induced PDH regulation in skeletal muscle is maintained in glucose-intolerant individuals.

  5. catalytic subunit of PDP1 crystals belonged to space group P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters a = b = 65.1, c = 216.1 A.

  6. pyruvate dehydrogenase phosphatase PDP1 is down-regulated in circulating lymphocytes of obese subjects because it is poorly sensitive to magnesium/calcium; this defect is attenuated when plasma insulin (show INS Proteins) is greatly enhanced

  7. Lower accumulation of free ADP and AMP (show APRT Proteins) after the FAT-adapt trial may be responsible for the decreased glycogenolysis and PDH activation during sprinting.

  8. In cultured skin fibroblasts from three patients with congenital lactic acidemia due to a defect in activation of the pyruvate dehydrogenase complex, the PDP-activity was significantly reduced to 50.7%, 64.6% and 63.1% of that of control fibroblasts.

  9. In postmortem tissue samples, from male child with metabolic acidosis, PDK (show PDK2 Proteins) normally reduced PDH-activity in ATP-presence. Addition of Ca++ and Mg++ did not restored PDH-activity. The defect was attributed to a markedly reduced PDP-activity.

Mouse (Murine) Pyruvate Dehydrogenase Phosphatase (PDP) interaction partners

  1. Mitochondrial PDP1 is a potential regulator that controls cardiac differentiation at an early differentiation stage in mouse embryonic stem cells.

  2. defects in PP2Cm (show PPM1K Proteins) may be responsible for a subset of human maple syrup urine disease

Pyruvate Dehydrogenase Phosphatase (PDP) Protein Profile

Protein Summary

Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported\; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with PDP

  • Pyruvate dehydrogenase phosphatase (Pdp)
  • pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1, mitochondrial (LOC413080)
  • pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1)
  • pyruvate dehyrogenase phosphatase catalytic subunit 1 (Pdp1)
  • pyruvate dehyrogenase phosphatase catalytic subunit 1 (pdp1)
  • pyruvate dehyrogenase phosphatase catalytic subunit 1 L homeolog (pdp1.L)
  • 153332_at protein
  • CG12151 protein
  • Dmel\\CG12151 protein
  • Gm1024 protein
  • im:7157162 protein
  • PDH protein
  • pdp protein
  • pdp1 protein
  • PDPC protein
  • ppm2c protein
  • zgc:174908 protein

Protein level used designations for PDP

CG12151-PA , CG12151-PB , Pdp-PA , Pdp-PB , pyruvate dehydrogenase phosphatase , PDP 1 , PDPC 1 , [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial , protein phosphatase 2C, magnesium-dependent, catalytic subunit , pyruvate dehydrogenase (Lipoamide) phosphatase-phosphatase , pyruvate dehydrogenase phosphatase catalytic subunit 1 , protein phosphatase 2C, magnesium dependent, catalytic subunit , pyruvate dehydrogenase phosphatase isoenzyme 2 , pyruvate dehydrogenase phosphatase isoenzyme 1 , pyruvate dehydrogenase phosphatase, catalytic subunit 1 , pyruvate dehyrogenase phosphatase catalytic subunit 1 , pyruvate dehyrogenase phosphatase catalytic subunit 1 L homeolog

GENE ID SPECIES
31683 Drosophila melanogaster
413080 Apis mellifera
54704 Homo sapiens
381511 Mus musculus
54705 Rattus norvegicus
280891 Bos taurus
100153002 Sus scrofa
477941 Canis lupus familiaris
558728 Danio rerio
447514 Xenopus laevis
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