PDP Products
(Pyruvate Dehydrogenase Phosphatase (PDP))
Categories
Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported\; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009].
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Featured PDP Categories
PDP Antibodies
High quality antibodies with extensive validation data.
PDP ELISA Kits
Reliable ELISA kits for a wide range of species.
PDP Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PDP Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Rat
Application
WB, IHC (p)
Validations
- (1)
- (3)
Cat. No.
ABIN656386
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (4)
Cat. No.
ABIN6145404
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC
Validations
- (3)
Cat. No.
ABIN7262136
Quantity
200 μL
Datasheet
Datasheet
Recommended PDP ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
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Cat. No.
ABIN6969803
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959011
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
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Cat. No.
ABIN1116879
Quantity
96 tests
Datasheet
Datasheet
Recommended PDP Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3085625
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3122191
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7392629
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PDP products
: "Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours." in: Scientific reports, Vol. 6, pp. 31146, (2016) (PubMed).: "Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth." in: The Journal of biological chemistry, Vol. 289, Issue 31, pp. 21413-22, (2014) (PubMed).
Synonyms and alternative names related to PDP
Pyruvate dehydrogenase phosphatase (Pdp), pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1, mitochondrial (LOC413080), pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1), pyruvate dehyrogenase phosphatase catalytic subunit 1 (Pdp1), pyruvate dehyrogenase phosphatase catalytic subunit 1 (pdp1), pyruvate dehyrogenase phosphatase catalytic subunit 1 L homeolog (pdp1.L), 153332_at, CG12151, Dmel\\CG12151, Gm1024, im:7157162, PDH, PDP, pdp, pdp1, PDPC, PPM2C, Ppm2c, ppm2c, zgc:174908Protein level used designations for PDP
- CG12151-PA
- CG12151-PB
- Pdp-PA
- Pdp-PB
- pyruvate dehydrogenase phosphatase
- PDP 1
- PDPC 1
- [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
- protein phosphatase 2C, magnesium-dependent, catalytic subunit
- pyruvate dehydrogenase (Lipoamide) phosphatase-phosphatase
- pyruvate dehydrogenase phosphatase catalytic subunit 1
- protein phosphatase 2C, magnesium dependent, catalytic subunit
- pyruvate dehydrogenase phosphatase isoenzyme 2
- pyruvate dehydrogenase phosphatase isoenzyme 1
- pyruvate dehydrogenase phosphatase, catalytic subunit 1
- pyruvate dehyrogenase phosphatase catalytic subunit 1
- pyruvate dehyrogenase phosphatase catalytic subunit 1 L homeolog
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