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Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum. Additionally we are shipping RINT1 Proteins (3) and and many more products for this protein.
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Study presents evidence that in the Caucasian population, RINT1 does not represent a moderate- penetrance breast cancer susceptibility gene, and find no evidence to support an association of RINT1 mutation with Lynch syndrome-related cancer incidence in breast cancer families.
these data are more consistent with the hypothesis that RINT1 functions as an oncogene rather than a tumor suppressor gene in the context of colorectal cancer.
HPV E2 protein targets Rad50-interacting protein 1 (Rint1) to facilitate virus genome replication.
RINT-1 interacts with MSP58 and UBF within nucleoli and plays a role in ribosomal gene transcription.
Results suggest that high RAD50 interactor 1 (RINT1) expression may represent a risk factor for low-grade gliomas (LGGs)-related seizures.
Results identified RINT1 as a putative breast cancer predisposition gene that also seems to be associated with risk for a spectrum of other cancers similar to those that have previously been described for Lynch syndrome.
RINT-1 is also required for endosome-to-trans-Golgi network trafficking.
RINT1 was validated as a novel glioblastoma oncogene
RINT-1 coordinates the localization and function of ZW10 by serving as a link between ZW10 and the SNARE complex comprising syntaxin 18.
These findings suggest that RINT-1 serves as a novel tumor suppressor essential for maintaining the dynamic integrity of the Golgi apparatus and the centrosome, a prerequisite to their proper coordination during cell division.
Rab6 regulates distinct Golgi trafficking pathways involving two separate protein complexes: ZW10/RINT-1 and COG.
Results together suggest that NAG links between p31 and ZW10-RINT-1 and is involved in Golgi-to-ER transport.
RINT1 has a role as a multitasking protein with roles in genomic stability, ER homeostasis, and autophagy
A crucial role of Rint1 in vivo in genomic stability maintenance, as well as in prevention of endoplasmic reticulum stress and autophagy.
Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum. May play a role in cell cycle checkpoint control. Essential for telomere length control.
RAD50-interacting protein 1