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The protein encoded by RAD54B belongs to the DEAD-like helicase superfamily.
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Review of structural aspects of RAD54B, molecular functions associated with its cellular roles in preventing genome instability, and how aberrant function contributes to oncogenesis.
RAD54B expression has potential to serve as a novel prognostic biomarker, particularly for distant recurrence in colorectal cancer
Patients with expression of both FEN1 (show FEN1 Proteins) and RAD54B were prone to have advanced nodal involvement and significantly poor prognosis.
The scaffolding function of Rad54B dynamically regulates the maintenance of genome integrity by limiting checkpoint strength.
support a model in which RAD54L (show ATRX Proteins) and RAD54B counteract genome-destabilizing effects of direct binding of RAD51 (show RAD51 Proteins) to dsDNA in tumor cells
RAD54B-deficient cells are selectively killed relative to controls via siRNA-based silencing of SOD1 (show SOD1 Proteins)
RAD54B and GREB1 gene polymorphisms may not be associated with PCOS in the Han Chinese population.
These results suggest that hINO80 assists double-strand break repair by positively regulating the expression of the Rad54B and XRCC3 (show XRCC3 Proteins) genes.
Rad54B is a DNA-dependent ATPase and has biochemical properties different from its structural homolog in yeast, Tid1 (show DNAJA3 Proteins)/Rdh54
Rad54B enhanced the DNA strand-exchange activity of Dmc1 (show DMC1 Proteins) by stabilizing the Dmc1 (show DMC1 Proteins)-single-stranded DNA complex.
The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer.
RAD54 homolog B (S. cerevisiae)
, RAD54 homolog B-like
, DNA repair and recombination protein RAD54B-like
, DNA repair and recombination protein RAD54B
, RAD54, S. cerevisiae, homolog of, B
, fibrinogen silencer-binding protein