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RANBP3 encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm.
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Human Polyclonal RANBP3 Primary Antibody for ICC, IF - ABIN261724
Oka, Asally, Yasuda, Ogawa, Tachibana, Yoneda: The mobile FG nucleoporin Nup98 is a cofactor for Crm1-dependent protein export. in Molecular biology of the cell 2010
Computational docking simulation indicates that phosphorylation of RanBP3 at Ser58 could potentially stabilize the association of RanBP3 with importin-alpha through interactions between the phosphate moiety of phospho-Ser58 of RanBP3 and a cluster of basic residues (Arg96 and Lys97 in importin-alpha3) on armadillo repeat 1 of importin-alpha.
RANBP3 regulates melanoma cell proliferation and probably a potential target for molecular targeted therapy.
RanBP3 is involved in vRNP nuclear export. The function of RanBP3 during vRNP nuclear export is regulated by phosphorylation at Ser58. RanBP3 phosphorylation is modulated by both PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) and Ras/ERK (show EPHB2 Antibodies)/RSK (show RPS6KA1 Antibodies) pathways in the late phase of viral infection.
Crystal structure of the Ran-binding domain (RBD (show CACNA1D Antibodies)) from RanBP3 and compare it to RBD (show CACNA1D Antibodies) structures from RanBP1 (show RANBP1 Antibodies) and RanBP2 (show RANBP2 Antibodies) in complex with Ran and CRM1 (show XPO1 Antibodies).
RanBP3 stimulates export by enhancing the affinity of Crm1 (show XPO1 Antibodies) for Ran-GTP (show AK3 Antibodies) and cargo.
A multifunctional domain in CRM1 (exportin 1 (show XPO1 Antibodies)) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein.
RANBP3 phosphorylation links the Ras and PI3-kinase (show PIK3CA Antibodies) pathways to nucleocytoplasmic transport.
RanBP3 directly recognizes dephosphorylated Smad2 (show SMAD2 Antibodies)/3, which results from the activity of nuclear Smad (show SMAD1 Antibodies) phosphatases, and mediates nuclear export of Smad2 (show SMAD2 Antibodies)/3 in a Ran-dependent manner.
Protein phosphatase PPM1A (show PPM1A Antibodies) regulates the nuclear export of Smad2 (show SMAD2 Antibodies)/3 through targeting nuclear exporter RanBP3.
This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
, ran-binding protein 3
, ran binding protein 3
, RAN binding protein 3