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This intronless gene belongs to a family of RAS-related genes.
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these results revealed that Rap2B promotes renal cell carcinoma (show MOK Antibodies) angiogenesis via phosphoinositide 3-kinase/AKT (show AKT1 Antibodies)/vascular endothelial growth factor (show VEGF Antibodies) signaling pathway, which suggests that Rap2B is a novel therapeutic target for renal cell carcinoma (show MOK Antibodies) anti-angiogenesis therapy.
our results suggested that Rap2b may be a potential therapeutic target for lung cancer.
knockdown of Rap2B inhibits the proliferation and invasion in HCC (show FAM126A Antibodies) cells. These findings reveal that Rap2B plays an important role in the regulation of HCC (show FAM126A Antibodies) progression.
miR (show MLXIP Antibodies)-194 is inversely correlated with RAP2B.
Western blot analysis uncovered that elevated Rap2B leads to increased phosphorylation levels of FAK (show PTK2 Antibodies), suggesting that FAK (show PTK2 Antibodies)-dependent pathway might be responsible for the effect of Rap2B on PCa (show FLVCR1 Antibodies) cells migration and invasion.
Expression and DNA methylation (show HELLS Antibodies) status of the Rap2B gene in human bronchial epithelial cells treated by cigarette smoke condensate
Our collective findings provide preliminary evidence that miR (show MLXIP Antibodies)-342-3p acts as a tumor suppressor in small cell lung cancer through repression of RAP2B.
Rap2B itself is not necessary for p53 (show TP53 Antibodies)-dependent cell cycle arrest.
Data indicate that rap (show LRPAP1 Antibodies) GTP-binding protein (show HCAR3 Antibodies) Rap2B expression is significantly increased in suprarenal epithelioma and Rap2B can promote the cell migration and invasion abilities, suggesting a target for the treatment of suprarenal epithelioma.
Rap2b mediates the pro-survival function of p53 (show TP53 Antibodies) upon DNA damage.
Taken together, these findings shed light on Rap2B as a therapeutic target for breast cancer.
the putative Rap2 (show RAP2A Antibodies) binding site of the RPIPx (show RUFY3 Antibodies) RUN domain interacts with the extended segment in a segment-swapping manner
This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated.
RAP2B, member of RAS oncogene family
, ras-related protein Rap-2b
, ras-dva small GTPase
, ras-like small GTPase
, small GTP binding protein