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The protein encoded by RAP2C is a member of the Ras-related protein subfamily of the Ras GTPase superfamily.
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Human Polyclonal RAP2C Primary Antibody for WB - ABIN1881727
Guo, Yuan, Tang, Chen, Gu, Luo, Wang, Wan, Yu: Cloning and characterization of the human gene RAP2C, a novel member of Ras family, which activates transcriptional activities of SRE. in Molecular biology reports 2007
Study found that SCII (show SMC2 Antibodies) upregulated the expression of miR (show MLXIP Antibodies)-204 and downregulated the expression of RAP2C; that hypoxia increased the expression of miR (show MLXIP Antibodies)-204 and decreased the expression of RAP2C, and overexpression of RAP2C attenuates the effect of hypoxia on apoptosis rate; and miR (show MLXIP Antibodies)-204 could directly bind to RAP2C, and could regulate the expression of RAP2C.
JAM-A (show F11R Antibodies) regulates epithelial permeability via association with ZO-2 (show TJP2 Antibodies), afadin (show MLLT4 Antibodies), and PDZ-GEF1 (show RAPGEF2 Antibodies) to activate Rap2c and control contraction of the apical cytoskeleton.
This work demonstrates that Rap2C is a new member of the Rap2 (show RAP2A Antibodies) subfamily of proteins, able to bind guanine nucleotides with peculiar properties, and differently expressed by various hematopoietic subsets
RAP2C is a novel member of the Ras family, belonging to the Rap (show LRPAP1 Antibodies) branch of small GTPase (show RACGAP1 Antibodies) proteins and may be involved in SRE-mediated gene transcription.
The protein encoded by this gene is a member of the Ras-related protein subfamily of the Ras GTPase superfamily. Members of this family are small GTPases that act as molecular switches to regulate cellular proliferation, differentiation, and apoptosis. This protein has been reported to activate in vitro transcriptional activity of the serum response element. Alternative splicing results in multiple transcript variants.
RAP2C, member of RAS oncogene family
, ras-related protein Rap-2c
, small GTPase RAP2C