anti-RAS P21 Protein Activator 3 (RASA3) Antibodies

The protein encoded by RASA3 is member of the GAP1 family of GTPase-activating proteins. Additionally we are shipping RAS P21 Protein Activator 3 Proteins (5) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RASA3 22821 Q14644
RASA3 19414 Q60790
RASA3 29372 Q9QYJ2
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Top anti-RAS P21 Protein Activator 3 Antibodies at antibodies-online.com

Showing 10 out of 95 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of RASA3 expression in HeLa (A), SP2/0 (B), H9C2 (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Goat Un-conjugated ELISA   100 μg 6 to 7 Days
$291.53
Details
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: H1299 7.5% SDS PAGE RASA3 antibody antibody diluted at 1:1000 100 μL 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB Western blot analysis of extracts from HeLa cells, using RASA3 antibody.The lane on the left is treated with the antigen-specific peptide. ABIN6275450 staining HeLa cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse embryo labeled with Anti-RASA3 Polyclonal Antibody, Unconjugated (ABIN760316) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat tongue labeled with Anti-RASA3 Polyclonal Antibody, Unconjugated (ABIN760316) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL 3 to 7 Days
$317.90
Details
Human Rabbit Un-conjugated WB Western blot analysis in ZR-75-1 cell line lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated WB Western Blot analysis of RASA3 expression in transfected 293T cell line by RASA3 MaxPab polyclonal antibody.Lane 1: RASA3 transfected lysate(91.74 KDa).Lane 2: Non-transfected lysate. 50 μL 11 to 12 Days
$440.00
Details
Bat Goat Un-conjugated ELISA   100 μg 11 to 14 Days
$507.83
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg 2 to 3 Days
$302.50
Details

Top referenced anti-RAS P21 Protein Activator 3 Antibodies

  1. Dog (Canine) Polyclonal RASA3 Primary Antibody for ELISA - ABIN547372 : Kuai, Wooters, Hall, Rao, Nickbarg, Li, Chatterjee-Kishore, Qiu, Lin: NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach. in The Journal of biological chemistry 2004 (PubMed)

More Antibodies against RAS P21 Protein Activator 3 Interaction Partners

Human RAS P21 Protein Activator 3 (RASA3) interaction partners

  1. Rasa3 is a critical regulator of Rap1 in endothelial cells which controls adhesions properties and vascular lumen integrity; its specific endothelial cell inactivation results in occluded blood vessels, hemorrhages and early embryonic death in mouse, mimicking thus the Rasa3-/- mouse phenotype.

  2. these results support an important role for Rasa3 in PI3K-dependent integrin alphaIIbbeta3-mediated outside-in signaling and cell spreading.

  3. the function of RASA3 during megakaryopoiesis, megakaryocyte adhesion and migration as well as integrin signaling has been reported.

  4. role in intracellular calcium homeostasis

  5. model in which the Ras GAP-related domain of GAP1(IP4BP) functions to stabilize the switch II region of Rap1, allowing stabilization of the transition state during GTP hydrolysis initiated by the arginine finger

  6. GAP1IP4BP is an inositol 1,3,4,5-tetrakisphosphate regulated plasma membrane associated Ras and Rap GAP. Membrane association results from its PH domain binding phosphatidylinositol 4,5-bisphosphate.

Mouse (Murine) RAS P21 Protein Activator 3 (RASA3) interaction partners

  1. RASA3 promoted proteasome-mediated IRF4 protein degradation by facilitating interaction of IRF4 with E3-ubiquitin ligase Cbl-b. Therefore, a RASA3-IRF4-Cbl-b pathway specifically directs pTh17 cell generation by balancing reciprocal Th17-Th2 cell programs. These findings indicate that a distinct molecular program directs pTh17 cell generation and reveals targets for treating pTh17 cell-related pathology and diseases.

  2. Rasa3 is a critical regulator of Rap1 in endothelial cells which controls adhesions properties and vascular lumen integrity; its specific endothelial cell inactivation results in occluded blood vessels, hemorrhages and early embryonic death in mouse, mimicking thus the Rasa3-/- mouse phenotype.

  3. these results support an important role for Rasa3 in PI3K-dependent integrin alphaIIbbeta3-mediated outside-in signaling and cell spreading.

  4. the function of RASA3 during megakaryopoiesis, megakaryocyte adhesion and migration as well as integrin signaling has been reported.

  5. our results indicate that Rasa3 catalytic activity controls Rap1 activation and integrin signaling during megakaryocyte differentiation in mouse.

  6. Expression of RASA3 led to premature platelet activation and markedly reduced the life span of circulating platelets.

  7. Identified is in the scat (severe combined anemia and thrombocytopenia) mouse model a missense mutation (G125V) in the Rasa3 gene, encoding a Ras GTPase activating protein.

  8. RASA3 plays a critical, conserved, and nonredundant role for RASA3 in vertebrate hematopoiesis.

RAS P21 Protein Activator 3 (RASA3) Antigen Profile

Protein Summary

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane.

Gene names and symbols associated with RASA3

  • RAS p21 protein activator 3 L homeolog (rasa3.L) antibody
  • RAS p21 protein activator 3 (RASA3) antibody
  • RAS p21 protein activator 3 (rasa3) antibody
  • ras GTPase-activating protein 3 (LOC100433573) antibody
  • RAS p21 protein activator 3 (Rasa3) antibody
  • AI326412 antibody
  • C86362 antibody
  • E130011G04 antibody
  • GAP1IP4BP antibody
  • GAPIII antibody
  • LOC100222817 antibody
  • MGC82492 antibody
  • R-ras gap antibody
  • RASA3 antibody
  • scat antibody

Protein level used designations for RASA3

RAS p21 protein activator 3 , ras GTPase-activating protein 3-like , GAP1(IP4BP) , GTPase activating protein III , Ins(1,3,4,5)P4-binding protein , inositol 1,3,4,5-tetrakisphosphate-binding protein , ins P4-binding protein , ras GTPase-activating protein 3 , GAPIII activator 3 , R-Ras gap , R-ras RTPase activating protein-3 , Ras GTPase-activating protein III , Ins P4-binding protein , R-Ras GTP activating protein , R-ras GTPase activating protein , RAS p21 protein activator (GTPase activating protein) 3 (Ins(1,3,4,5)P4-binding protein)

GENE ID SPECIES
446637 Xenopus laevis
452684 Pan troglodytes
698964 Macaca mulatta
100144662 Xenopus (Silurana) tropicalis
100222817 Taeniopygia guttata
100433573 Pongo abelii
100478760 Ailuropoda melanoleuca
100560638 Anolis carolinensis
100580920 Nomascus leucogenys
22821 Homo sapiens
19414 Mus musculus
29372 Rattus norvegicus
476998 Canis lupus familiaris
418736 Gallus gallus
282532 Bos taurus
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