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Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Additionally we are shipping RCAN Family Member 3 Antibodies (82) and many more products for this protein.
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The tumor suppressor effect of RCAN3 in breast cancer depends on the interaction with calcineurin.
Studies indicate that RCAN3 is composed of a multigene system that includes at least 21 alternative spliced isoforms.
Data shows RCAN3 inhibits HUVEC proliferation both basally and under VEGF (show VEGFA Proteins) or phorbol 12-myristate 13-acetate-stimulated conditions, however it does not modulate gene expression of the chosen inflammatory genes.
our data have elucidated the molecular and cellular mechanism whereby PGF (show PGF Proteins)(2alpha) regulates CXCL8 (show IL8 Proteins) expression via the FP receptor (show PTGFR Proteins) in endometrial adenocarcinomas and have highlighted RCAN1 (show RCAN1 Proteins)-4 as a negative regulator of CXCL8 (show IL8 Proteins) expression
The yeast cotransformation and GST fusion protein assay demonstrated the interaction between this new DSCR1L2 variant and the human cardiac troponin I.
human RCAN3, encoded by the RCAN3 (also known as DSCR1L2) gene, interacts physically and functionally with calcineurin
The interaction between TNNI3 (show TNNI3 Proteins) and the new R variants of RCAN3, RCAN3-2,3,5 and RCAN3-2,4,5, is reported.
found that RCAN1 (show RCAN1 Proteins)/3 interact with RAF (show RAF1 Proteins) kinases and CN in a non-exclusive manner. Our data suggests that the balance of RCAN interactions with CN and/or RAF (show RAF1 Proteins) kinases may influence T cell positive selection
the adult mice, RCAN3 was mainly expressed in the neuropil throughout the brain.
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity).
RCAN family member 3
, Down syndrome critical region gene 1-like 2
, regulator of calcineurin 3
, Down syndrome candidate region 1-like 2
, down syndrome candidate region 1-like protein 2
, myocyte-enriched calcineurin-interacting protein 3
, regulator of calcineurin 3 isoform 1b,2