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RBM39 encodes a member of the U2AF65 family of proteins.
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Human Polyclonal RBM39 Primary Antibody for IP, WB - ABIN223403
Sotgia, Del Galdo, Casimiro, Bonuccelli, Mercier, Whitaker-Menezes, Daumer, Zhou, Wang, Katiyar, Xu, Bosco, Quong, Aronow, Witkiewicz, Minetti, Frank, Jimenez, Knudsen, Pestell, Lisanti: Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts. in The American journal of pathology 2009
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RBM39 is extensively involved in alternative splicing of RNA and helps regulate transcript levels. RBM39 may modulate alternative splicing similarly to U2AF65 (show U2AF59 Antibodies) by either directly binding to RNA or recruiting other splicing factors, such as U2AF65 (show U2AF59 Antibodies).
The results provide a mechanism for exon 16 3' splice site activation in which a coordinated effort among TIA1 (show TIA1 Antibodies), Pcbp1 (show PCBP1 Antibodies), and RBM39 stabilizes or increases U2 snRNP (show LSM2 Antibodies) recruitment, enhances spliceosome A complex formation, and facilitates exon definition through RBM39-mediated splicing regulation.
This study therefore establishes a structural basis for specific UHM-ULM interactions by splicing factors such as U2AF35 (show U2AF1 Antibodies), U2AF65 (show U2AF59 Antibodies), RBM39 and SF3b155 (show SF3B1 Antibodies), and a platform for continued studies of intermolecular interactions governing disease-related alternative splicing in eukaryotic cells.
mammalian c-Abl (show ABL1 Antibodies) plays an important role in steroid hormone receptor (show NR4A1 Antibodies)-mediated transcription by regulating RBM39
Knockdown of CAPER expression markedly reduced human breast cancer cell proliferation in both in vitro and in vivo settings. Mechanistically, knockdown of CAPER abrogated the activity of proliferative and protein synthesis pathways.
identify SF3b155 (show SF3B1 Antibodies) as the relevant ULM-containing partner of full-length CAPERalpha in human cell extracts.
Data show that CSE1L (show CSE1L Antibodies), DIDO1 (show DIDO1 Antibodies) and RBM39 mRNA expression levels correlated with chromosome 20q DNA copy number status.
Increased VEGF (show VEGFA Antibodies)(165) expression is secondary to the down-regulation of CAPER-alpha by EWS (show EWSR1 Antibodies)/FLI-1 (show FLI1 Antibodies). CAPER-alpha mediates alternative splicing and controls the shift from VEGF (show VEGFA Antibodies)(189) to VEGF (show VEGFA Antibodies)(165) .
this study identifies CAPERalpha (RNA binding motif protein 39) as a new transcriptional coregulator for v-Rel (show NFkBP65 Antibodies) and reveals an important role in modulating Rel's oncogenic activity.
Analysis of human breast cancer samples revealed that CAPER is overexpressed and undergoes a cytoplasmic-to-nuclear shift during the transition from pre-malignancy to ductal carcinoma in situ
this study shows that negative autoregulation of BMP4 (show BMP4 Antibodies) dependent transcription by SIN3B (show SIN3B Antibodies) splicing reveals a role for RBM39
CAPER integrates mitochondrial energy metabolism by coactivating ERR-alpha (show ESRRA Antibodies)-Gabpa (show GABPA Antibodies) and stress-induced adaptive metabolic responses via NF- kappaB (show NFKB1 Antibodies)/c-Myc (show MYC Antibodies).
This gene encodes a member of the U2AF65 family of proteins. The encoded protein is found in the nucleus, where it co-localizes with core spliceosomal proteins. It has been shown to play a role in both steroid hormone receptor-mediated transcription and alternative splicing, and it is also a transcriptional coregulator of the viral oncoprotein v-Rel. Multiple transcript variants have been observed for this gene. A related pseudogene has been identified on chromosome X.
RNA binding motif protein 39
, RNA binding motif protein 39, isoform 1
, RNA-binding protein 39
, RNA-binding protein 39-like
, RNA-binding region (RNP1, RRM) containing 2
, coactivator of activating protein-1 and estrogen receptors
, functional spliceosome-associated protein 59
, hepatocellular carcinoma protein 1
, splicing factor HCC1
, RNA-binding motif protein 39
, RNA-binding region-containing protein 2
, coactivator of AP-1 and ERs
, coactivator of activating protein 1 and estrogen receptors
, transcription coactivator CAPER