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RNA-binding protein that regulates alternative splicing events (By similarity).. Additionally we are shipping NEUN Proteins (3) and many more products for this protein.
Showing 10 out of 110 products:
Human Polyclonal NEUN Primary Antibody for IF (p), IHC (p) - ABIN732068
Jiang, Tian, Fu, Zhu, Hou: Neuroprotective efficacy and therapeutic window of Forsythoside B: in a rat model of cerebral ischemia and reperfusion injury. in European journal of pharmacology 2010
Show all 13 Pubmed References
Human Polyclonal NEUN Primary Antibody for ICC, IF - ABIN4349539
Sámano, Nasrabady, Nistri: A study of the potential neuroprotective effect of riluzole on locomotor networks of the neonatal rat spinal cord in vitro damaged by excitotoxicity. in Neuroscience 2012
Show all 9 Pubmed References
Cow (Bovine) Monoclonal NEUN Primary Antibody for CyTOF, FACS - ABIN4349542
Morfini, Bosco, Brown, Gatto, Kaminska, Song, Molla, Baker, Marangoni, Berth, Tavassoli, Bagnato, Tiwari, Hayward, Pigino, Watterson, Huang, Banker, Brown, Brady: Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase. in PLoS ONE 2013
Show all 4 Pubmed References
Human Polyclonal NEUN Primary Antibody for ICC, IF - ABIN4349540
Bergmann, Liebl, Bernard, Alkass, Yeung, Steier, Kutschera, Johnson, Landén, Druid, Spalding, Frisén: The age of olfactory bulb neurons in humans. in Neuron 2012
Show all 2 Pubmed References
Human Polyclonal NEUN Primary Antibody for ICC, IF - ABIN4349562
Robinson, Chapani, Styan, Vaidyanathan, Willerth: Functionalizing Ascl1 with Novel Intracellular Protein Delivery Technology for Promoting Neuronal Differentiation of Human Induced Pluripotent Stem Cells. in Stem cell reviews 2016
Cow (Bovine) Polyclonal NEUN Primary Antibody for ICC, IF - ABIN4349544
Zhang, Wang, Tang, Dong, Chan, Sareddy, Vadlamudi, Brann: Brain-derived estrogen exerts anti-inflammatory and neuroprotective actions in the rat hippocampus. in Molecular and cellular endocrinology 2014
Cow (Bovine) Monoclonal NEUN Primary Antibody for FACS - ABIN4349556
Cohen, Ke, Liu, Fu, Majnik, Lane: Adverse early life environment increases hippocampal microglia abundance in conjunction with decreased neural stem cells in juvenile mice. in International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2016
Human Polyclonal NEUN Primary Antibody for IF (p) - ABIN908077
Fontes, Ramsey, Polk, Koop, Denisova, Belousov: Death of Neurons following Injury Requires Conductive Neuronal Gap Junction Channels but Not a Specific Connexin. in PLoS ONE 2015
Human Polyclonal NEUN Primary Antibody for IF (p) - ABIN732072
Song, Gaudin, King, Seo, Suh, Deng, Cui, Tietjen, Huttner, Saltzman: Surface chemistry governs cellular tropism of nanoparticles in the brain. in Nature communications 2017
Human Polyclonal NEUN Primary Antibody for IF (p) - ABIN732074
Ridder, Sevko, Heide, Dams, Rupp, Macas, Starmann, Tjwa, Plate, Sültmann, Altevogt, Umansky, Momma: Extracellular vesicle-mediated transfer of functional RNA in the tumor microenvironment. in Oncoimmunology 2015
RBFOX3 knockdown synergized with 5-FU to inhibit the growth and invasion of HCC (show FAM126A Antibodies) cells through PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) and epithelial-mesenchymal transition (EMT (show ITK Antibodies)) signaling, and promote apoptosis by activating the cytochrome-c (show CYCS Antibodies)/caspase (show CASP3 Antibodies) signaling pathway.
In human lung tissue, Claudin-1 (show CLDN7 Antibodies) is higher in RBFOX3-positive cells than in RBFOX3-negative cells. Immunostaining and mRNA quantification revealed that protein levels, but not mRNA levels, of Claudin-1 (show CLDN7 Antibodies) are increased by RBFOX3.
SNPs (rs9900428, rs9907432 and rs7211029) in RBFOX3 associate with sleep latency.
this study show that TGF-beta (show TGFB1 Antibodies)-induced RBFOX3 inhibition plays an important role in epithelial-mesenchymal transition and lung cancer progression
NeuN was recently eventually identified as an epitope of Rbfox3. NeuN is highly conserved among species and is stably expressed during specific stages of development. NeuN has been considered to be a reliable marker of mature neurons, however, this role has been challenged by recent studies indicating that NeuN staining is variable and even absent during certain diseases and states. Review.
RBFOX proteins can facilitate the splicing of micro-exons. We also found that PTBP1 (show PTBP1 Antibodies) likely regulates the inclusion of micro-exons, possibly by repressing the inclusion of micro-exons that are enhanced by RBFOX proteins and other splicing factors.[RBFOX]
RNA splicing occurs in the nucleus hence, the altered localization of RbFox3 to the cytoplasm may lead to the downregulation of neuronal gene expression.
Exome sequencing of 242 rolandic epilepsy patients revealed two novel probably deleterious variants in RBFOX1 (show A2BP1 Antibodies), a frameshift mutation (p.A233Vfs*74) and a hexanucleotide deletion (p.A299_A300del), and a novel nonsense mutation in RBFOX3 (p.Y287*).
High NeuN levels are associated with supratentorial ependymomas.
NeuN immunocytochemical reaction in neurons of human substantia nigra was expressed much weaker than in the nucleus rubrum neurons located in the same sections.
Rbfox3-/- mice displayed normal non-image and image forming functions. Taken together, our results suggest RBFOX3 is dispensable for visual function
Results demonstrate the important role of RBFOX3 during neural development and maturation and show that abnormalities in synaptic structure and function occur in Rbfox3 homozygous knockout mice. These findings may offer mechanistic explanations for human brain diseases associated with dysfunctional RBFOX3.
RBFOX3/NeuN is Required for Hippocampal Circuit Balance and Function.
In vitro analyses revealed that Rbfox3 functions as a positive and a negative regulator at the stage of pri-miRNA processing to precursor miRNA (pre-miRNA).
Rbfox3-dependent Numb (show NUMB Antibodies) alternative splicing plays an important role in the progression of neuronal differentiation during vertebrate development.
the negative regulation of Rbfox2 (show RBM9 Antibodies) by Rbfox3 through a novel mechanism
During the development of olfactory bulb and epithelium, NeuN is expressed only in mature neural cells migrating from margin area to the inner granule cells layer of olfactory bulb.
NeuN is the Fox-3 gene product and its expression is restricted to neural tissues.
Enzymatic dephosphorylation abolishes NeuN immunoreactivity, confirming that NeuN is indeed a phosphoprotein, and establishing that binding of the defining antibody depends on its state of phosphorylation.
Data show that inhibition of ZNF238 (RP58 (show ZNF238 Antibodies)) expression in mouse GNPs decreases the expression of the neuronal differentiation markers MAP2 and NeuN and downregulates the expression of the cell cycle arrest protein p27 (show CDKN1B Antibodies), a regulator of GNP differentiation.
RNA-binding protein that regulates alternative splicing events (By similarity).
RNA binding protein fox-1 homolog 3
, fox-1 homolog C
, hexaribonucleotide binding protein 3
, neuronal nuclei
, neuronal nuclear antigen A60
, RNA binding protein, fox-1 homolog 3