anti-Ras and Rab Interactor 1 (RIN1) Antibodies

Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Additionally we are shipping RIN1 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RIN1 9610 Q13671
RIN1 225870 Q921Q7
RIN1 207119 P97680
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Top anti-RIN1 Antibodies at antibodies-online.com

Showing 10 out of 64 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of RIN1 expression in HeLa (A), NIH3T3 (B), rat brain (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from K562 cells, using RIN1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB Western blot analysis of extracts from K562 cells, using RIN1 antibody. ABIN6275448 staining Hela cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Available
$363.46
Details
Human Rabbit Un-conjugated IP, WB RIN1 MaxPab rabbit polyclonal antibody. Western Blot analysis of RIN1 expression in IMR-32. Immunoprecipitation of RIN1 transfected lysate using anti-RIN1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with RIN1 purified MaxPab mouse polyclonal antibody (B01P) . 100 μL 11 to 12 Days
$425.71
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB Western Blot analysis of RIN1 expression in transfected 293T cell line by RIN1 MaxPab polyclonal antibody.Lane 1: RIN1 transfected lysate(84.10 KDa).Lane 2: Non-transfected lysate. RIN1 MaxPab rabbit polyclonal antibody. Western Blot analysis of RIN1 expression in IMR-32. 100 μg 11 to 12 Days
$425.71
Details
Human Mouse Un-conjugated WB Western Blot analysis of RIN1 expression in transfected 293T cell line by RIN1 MaxPab polyclonal antibody.Lane 1: RIN1 transfected lysate(86.13 KDa).Lane 2: Non-transfected lysate. RIN1 MaxPab polyclonal antibody. Western Blot analysis of RIN1 expression in rat brain. 50 μg 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated WB   100 μL 11 to 14 Days
$522.50
Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged RIN1 is approximately 0.03ng/ml as a capture antibody. 100 μg 11 to 12 Days
$440.00
Details

Top referenced anti-RIN1 Antibodies

  1. Human Polyclonal RIN1 Primary Antibody for IHC, IHC (p) - ABIN4350556 : Balaji, French, Miller, Colicelli: The RAB5-GEF function of RIN1 regulates multiple steps during Listeria monocytogenes infection. in Traffic (Copenhagen, Denmark) 2014 (PubMed)

More Antibodies against RIN1 Interaction Partners

Human Ras and Rab Interactor 1 (RIN1) interaction partners

  1. Findings suggest that RIN1 plays an important oncogenic role in clear cell renal cell carcinoma malignancy by activation of EGFR signaling through interacting with Rab25.

  2. Smad2 is a key scaffold, allowing RIN1 to act as a GTP exchange factor for MFN2-GTPase activation to promote mitochondrial ATP synthesis and suppress superoxide production during mitochondrial fusion.

  3. Overexpression experiments in tandem with pull-down assays indicated that specific Ser291/292 phosphorylation of RIN1 favored binding to activated Ras

  4. analysis of a novel deregulated mechanism in chronic myeloid leukemia patients, indicating BIN1 and RIN1 as players in the maintenance of the abnormal RTK signaling in this hematological disease

  5. Findings suggest that RIN1 orchestrates RAB5 activation, ABL kinase activation and BIN1 recruitment to determine EGFR fate.

  6. over-expression of RIN1 may play an important role in the progression of non-small cell lung cancer and RIN1 expression may offer a valuable marker for predicting the outcome of patients with NSCLC

  7. RIN1 plays an important role in gastric adenocarcinoma progression and that a high RIN1 expression predicts an unfavorable prognosis in gastric adenocarcinoma patients.

  8. RIN1 expression could be a potential prognostic predictor for the melanoma patients and provide a potential target therapy for melanoma treatment.

  9. RIN1 expression could be a potential prognostic predictor for bladder urothelial carcinoma (UC) patients.

  10. These data identify a novel PKD signaling pathway through RIN1 and Abl kinases that is involved in the regulation of actin remodeling and cell migration.

  11. BCR-ABL1 kinase activity is regulated by RIN1

  12. Plays an important role in both insulin receptor membrane trafficking and signaling.

  13. These results indicate that the RIN1 gene serves as an important signal transduction system for evaluating the malignancy of colorectal cancer.

  14. Rin1 regulates EGFR degradation in cooperation with STAM

  15. In a tumor cell line, RIN1 silencing may contribute to breast cancer progression.

  16. Specific residues of RIN1 are required for its interaction with Rab5, binding to the endosomal membranes and subsequent regulation of the fusion reaction.

  17. Mutations in the Vps9 domain of Rin1 lead to a loss-of-function phenotype, indicating a specific structure-function relationship between Rab5 and Rin1.

  18. Data demonstrate that proper internalization and endocytic trafficking are critical for EGFR-mediated signaling in A549 cells and suggest that up-regulation of Rin1 in A549 cell lines may contribute to their proliferative nature.

  19. the novel RIN1 mRNA was found to be expressed in gastric and colon cancer cell lines, suggesting that it is an important gene for the function of cancer cells.

Mouse (Murine) Ras and Rab Interactor 1 (RIN1) interaction partners

  1. BCR-ABL1 kinase activity is regulated by RIN1

  2. These results provide insight into regulated expression of Rin1, define a promoter useful in telencephalic neuron studies, and describe a novel REST site variant directing expression to mature neurons.

  3. This study provided evidence that Rin1 normally functions as a negative regulator of fear learning and memory (Rin1-/- mice have enhanced fear conditioning and diminished fear extinction).

  4. Rin1 links histone ubiquitylation to gene silencing and X inactivation.

  5. RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration.

  6. the EphA4 receptor is required for synaptic plasticity in the amygdala, raising the possibility that an underlying mechanism of Rin1 function in amygdala is to down-regulate EphA4 signaling by promoting its endocytosis.

RIN1 Antigen Profile

Protein Summary

Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.

Gene names and symbols associated with RIN1

  • Ras and Rab interactor 1 (RIN1) antibody
  • Ras and Rab interactor 1 (Rin1) antibody
  • RIN1 antibody

Protein level used designations for RIN1

Ras and Rab interactor 1 , ras and Rab interactor 1-like , ras and Rab interactor 1 , ras inhibitor 1 , ras inhibitor JC99 , ras inhibitor RIN1 , ras interaction/interference protein 1 , ras inhibitor

GENE ID SPECIES
611928 Canis lupus familiaris
714321 Macaca mulatta
100058267 Equus caballus
100395614 Callithrix jacchus
100437658 Pongo abelii
100482238 Ailuropoda melanoleuca
9610 Homo sapiens
225870 Mus musculus
207119 Rattus norvegicus
100520715 Sus scrofa
509295 Bos taurus
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