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RRAGC encodes a member of the GTR/RAG GTP-binding protein family. Additionally we are shipping Ras-Related GTP Binding C Antibodies (74) and many more products for this protein.
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Multiple RRAGC mutations demonstrated elevated MTOR (show FRAP1 Proteins) activation.
Full-length RagA (show RRAGA Proteins)(GTP (show AK3 Proteins)):RagC(GDP) dimer binds to regulator to activate mTORC1.
The dynamic response of mTORC1 requires intersubunit communication by the Rag GTPases, providing a rationale for why they exist as a dimer and revealing a distinct mode of control for a GTP-binding protein.
These findings implicate mTORC1 dysregulation through a gain-of-function mutation in RagC as a novel molecular basis for syndromic forms of pediatric heart failure, and expand genotype-phenotype correlation in RASopathy-related syndromes
activating nature of the RRAGC mutations, their existence in the dominant clone and their stability during disease progression support their potential as an excellent candidate for therapeutic targeting
FLCN (show FLCN Proteins) and its binding partners, FNIP1/2, are Rag-interacting proteins with GAP activity for RagC/D, but not RagA (show RRAGA Proteins)/B.
The constitutively active RagA (show RRAGA Proteins)-RagC heterodimer blocks the inhibitory effect of alcohol (EtOH).
This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants.
GTPase-interacting protein 2
, Rag C protein
, ras-related GTP-binding protein C
, rag C
, small GTPase homolog
, small GTPase, homolog
, Ras-related GTP binding C
, ras-related gtp-binding protein c