Receptor Accessory Protein 1 Proteins (REEP1)

REEP1 encodes a mitochondrial protein that functions to enhance the cell surface expression of odorant receptors. Additionally we are shipping Receptor Accessory Protein 1 Antibodies (97) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
REEP1 65055 Q9H902
REEP1 52250 Q8BGH4
Rat REEP1 REEP1 362384  
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Top Receptor Accessory Protein 1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,262.31
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Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$7,493.38
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
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REEP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Receptor Accessory Protein 1 (REEP1) Interaction Partners

Human Receptor Accessory Protein 1 (REEP1) interaction partners

  1. This study demonstrated that REEP1 gene mutation associated with hereditary spastic paraplegias in group of Polish patients

  2. we show that REEP1 facilitates endoplasmic reticulum mitochondria interactions, a function diminished by disease-associated mutations.

  3. Nonsense variants in REEP1 causing haploinsufficiency/loss of function are responsible for autosomal dominant hereditary spastic paraplegia (HSP)-type SPG31.

  4. Functional mutation analysis reveal that distinct pathomechanisms are associated with REEP1 mutations and shed new light on its probable functions.

  5. Expression of the REEP1/REEP2 subfamily appears to be restricted to neuronal and neuronal-like exocytotic tissues, consistent with neuronally restricted symptoms of REEP1 genetic disorders.

  6. REEP1 is a neuron-specific, membrane-binding, and membrane curvature-inducing protein that resides in the endoplasmic reticulum.

  7. A novel REEP1 mutation is identified in a cohort of patients with upper motor neuron syndrome.

  8. Whole-exome sequencing of two affected individuals revealed a single candidate variant within the linking regions, i.e., a splice-site alteration in REEP1

  9. Identification of 12 different heterozygous REEP1 mutations, including two exon deletions, associated with either a pure or a complex phenotype.

  10. previously unreported autosomal dominant mutations in the REEP1 gene in hereditary spastic paraplegia

  11. Hereditary spastic paraplegias(HSP) proteins atlastin-1, spastin, and REEP1 interact within the tubularER membrane in corticospinal neurons to coordinate ER shaping and microtubule dynamics.

  12. Receptor expression-enhancing protein 1 gene (SPG31) mutations are rare in Chinese Han patients with hereditary spastic paraplegia.

  13. RTP and REEP gene expression in human circumvallate papillae and testis, both of which are sites of taste receptor gene expression.

  14. REEP1 is widely expressed and localizes to mitochondria, which underlines the importance of mitochondrial function in neurodegenerative disease.

  15. Mutations in the receptor expression enhancing protein 1 (REEP1) have recently been reported to cause autosomal dominant hereditary spastic paraplegia type SPG31. We identified 13 novel and 2 known REEP1 mutations in 16 familial and sporadic patients.

  16. Our results confirm the previously observed mutation range of 3% to 6.5%, respectively, and they widen the spectrum of REEP1 mutations

  17. Results identify the frequency of REEP1 mutations in both autosomal dominant HSP (ADHSP) and sporadic spastic paraparesis (SSP) and analyse the genotype/phenotype correlation of mutations so far described in REEP1.

  18. A novel splice-site mutation (REEP1 c417+1g>a) was identified in chiease family of ADHSP.

Mouse (Murine) Receptor Accessory Protein 1 (REEP1) interaction partners

  1. REEP1 co-immunoprecipitates with seipin in cells. This strengthens the link between alterations in reticulum morphogenesis and lipid abnormalities, with important pathogenic implications for the most common forms of Hereditary spastic paraplegias.

  2. Functional mutation analysis reveal that distinct pathomechanisms are associated with REEP1 mutations and shed new light on its probable functions.

Receptor Accessory Protein 1 (REEP1) Protein Profile

Protein Summary

This gene encodes a mitochondrial protein that functions to enhance the cell surface expression of odorant receptors. Mutations in this gene cause spastic paraplegia autosomal dominant type 31, a neurodegenerative disorder. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with REEP1

  • receptor accessory protein 1 (REEP1)
  • receptor accessory protein 1 (Reep1)
  • C2orf23 protein
  • D6Ertd253e protein
  • HMN5B protein
  • RGD1305230 protein
  • SPG31 protein

Protein level used designations for REEP1

receptor expression-enhancing protein 1 , receptor expression enhancing protein 1

GENE ID SPECIES
65055 Homo sapiens
52250 Mus musculus
362384 Rattus norvegicus
771776 Gallus gallus
613003 Canis lupus familiaris
616916 Bos taurus
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