anti-Receptor Protein Tyrosine Phosphatase (PTPRT) Antibodies

The protein encoded by PTPRT is a member of the protein tyrosine phosphatase (PTP) family. Additionally we are shipping PTPRT Proteins (6) and PTPRT Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PTPRT 11122 O14522
PTPRT 19281 Q99M80
PTPRT    
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Top anti-PTPRT Antibodies at antibodies-online.com

Showing 10 out of 41 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Goat Un-conjugated ELISA, WB ABIN185288 staining (0.3µg/ml) of Human Brain lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg 6 to 7 Days
$429.84
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PTPRT Antibody Titration: 1.0 ug/ml Positive Control: COLO205 Whole Cell 100 μL 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p), WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with PTPRT antibody ABIN337325 at 5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. Anti-PTPRT antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg 11 to 14 Days
$484.00
Details
Human Goat Un-conjugated WB   0.1 mg 4 to 8 Days
$462.00
Details
Human Goat Un-conjugated EIA, IHC (p), WB 50 μg 6 to 8 Days
$495.00
Details
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL 11 to 13 Days
$335.04
Details
Human Mouse Un-conjugated ELISA, WB 100 μL 11 to 14 Days
$463.83
Details
Human Goat Un-conjugated IHC (p), ELISA, WB 50 μg 12 to 14 Days
$686.14
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemical staining of human pancreas with PTPRT polyclonal antibody  shows strong cytoplasmic positivity in exocrine glandular cells. 100 μL 11 to 12 Days
$577.33
Details

Top referenced anti-PTPRT Antibodies

  1. Human Monoclonal PTPRT Primary Antibody for ELISA, WB - ABIN534407 : Besco, Hooft van Huijsduijnen, Frostholm, Rotter: Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT). in Brain research 2006 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal PTPRT Primary Antibody for IP, WB - ABIN534441 : Zhang, Guo, Yu, Possemato, Chen, Zheng, Polakiewicz, Kinzler, Vogelstein, Velculescu, Wang: Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal PTPRT Primary Antibody for ELISA, WB - ABIN547345 : Wang, Shen, Parsons, Bardelli, Sager, Szabo, Ptak, Silliman, Peters, van der Heijden, Parmigiani, Yan, Wang, Riggins, Powell, Willson, Markowitz, Kinzler, Vogelstein, Velculescu: Mutational analysis of the tyrosine phosphatome in colorectal cancers. in Science (New York, N.Y.) 2004 (PubMed)

More Antibodies against PTPRT Interaction Partners

Human Receptor Protein Tyrosine Phosphatase (PTPRT) interaction partners

  1. A novel de novo 20q13.11q13.12 microdeletion was found in a boy with neurodevelopmental disorders. The established function of the PTPRT gene suggests that haploinsuficiency of this gene may result in the clinical features observed in our patient: stereotype movements, nervous tics, social and emotional disturbances and attention-span deficits.

  2. The single cell genotyping not only confirmed the co-occurrence of the PTPRT, CAND1 and DOCK6 mutations in the same AML clone but also revealed a clonal hierarchy, as the PTPRT mutation was likely acquired after the CAND1 and DOCK6 mutations.

  3. PTPRT promoter methylation is significantly associated with sensitivity to STAT3 inhibition in HNSCC cells, suggesting that PTPRT promoter methylation may serve as a predictive biomarker for responsiveness to STAT3 inhibitors in clinical development

  4. Data reported evidence that rs2866943 polymorphism in PTPRT 3'-UTR was involved in the occurrence of esophageal squamous cell carcinoma by acting as a protective factor while rs6029959 acts as a risk factor.

  5. Data show that hepatitis B virus X protein mutant HBxDelta127 enhances proliferation of hepatoma cells through up-regulating miR-215 targeting protein tyrosine phosphatase, receptor type T (PTPRT).

  6. tumor-specific mutational events in the PTPRT gene can serve as direct drivers for tumor growth by inducing hyperactivation of STAT3, a potent oncogenic transcription factor and PTPRT substrate

  7. The catalytic domain point mutants show a decreased thermal and thermodynamic stability and decreased activation energy relative to phosphatase activity, when compared to wild- type

  8. [review] High-throughput mutational analysis identifies loss-of-function mutations in six PTPs in human colon cancers, providing critical cancer genetics evidence that PTPs can act as tumour suppressor genes.

  9. Data show that paxillin is a direct substrate of PTPRT and that PTPRT specifically regulates paxillin phosphorylation at tyrosine residue 88(Y88).

  10. alterations of the PTPRT-mediated signaling pathway by PTPRT phosphatase domain mutation may not play a critical role in the development of common human cancers

  11. STAT3 is a substrate of receptor protein tyrosine phosphatase T

  12. brain-specific PTPRT regulates synapse formation through interaction with cell adhesion molecules, and this function and the phosphatase activity are attenuated through tyrosine phosphorylation by the synaptic tyrosine kinase Fyn.

Mouse (Murine) Receptor Protein Tyrosine Phosphatase (PTPRT) interaction partners

  1. Receptor protein tyrosine phosphatase rho (RPTPrho, gene symbol PTPRT) is a transmembrane protein expressed at high levels in the developing hippocampus, olfactory bulb, cortex, and cerebellum.

  2. These studies implicate PTPRT-modulated STAT3 signaling in the regulation of high-fat diet-induced obesity

  3. BCR is a novel substrate of PTPRT .

  4. Data show that paxillin is a direct substrate of PTPRT and that PTPRT specifically regulates paxillin phosphorylation at tyrosine residue 88(Y88).

PTPRT Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

Gene names and symbols associated with PTPRT

  • protein tyrosine phosphatase, receptor type T (PTPRT) antibody
  • protein tyrosine phosphatase, receptor type, T (Ptprt) antibody
  • mKIAA0283 antibody
  • RPTP-rfo antibody
  • RPTPrho antibody

Protein level used designations for PTPRT

R-PTP-T , RPTP-rho , receptor protein tyrosine phosphatase , receptor-type tyrosine-protein phosphatase T , receptor-type tyrosine-protein phosphatase rho , RPTPmam4 , mRPTPrho , receptor protein tyrosine phosphatase-rho

GENE ID SPECIES
11122 Homo sapiens
19281 Mus musculus
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