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RCAN2 encodes a member of the regulator of calcineurin (RCAN) protein family. Additionally we are shipping RCAN2 Antibodies (54) and and many more products for this protein.
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RCAN2 expression is upregulated in human masticatory mucosa during wound healing
our data have elucidated the molecular and cellular mechanism whereby PGF (show PGF Proteins)(2alpha) regulates CXCL8 (show IL8 Proteins) expression via the FP receptor (show PTGFR Proteins) in endometrial adenocarcinomas and have highlighted RCAN1 (show RCAN1 Proteins)-4 as a negative regulator of CXCL8 (show IL8 Proteins) expression
the expression of ZAKI-4 isoforms is subjected to distinct hormonal as well as tissue-specific regulation, constituting a complex signalling network through inhibition of calcineurin.
DSCR1 (show RCAN1 Proteins)-L1 is constitutively expressed in endothelial cells and acts similar to DSCR1 (show RCAN1 Proteins) in inhibiting calcineurin activity and restraining VEGF (show VEGFA Proteins)-mediated angiogenesis.
RCANs play critical roles in bone homeostasis by regulating both osteoclastogenesis and osteoblastogenesis, and they serve as inhibitors for calcineurin-NFATc1 (show NFATC1 Proteins) signaling both in vivo and in vitro.
our results indicate that Rcan2 and estradiol might regulate body weight through different mechanisms in female mice. Rcan2 increases food intake and promotes weight gain, while estradiol increases energy expenditure possibly by regulating physical activity.
Rcan2 and Rps6kb1 (show RPS6KB1 Proteins) mutations both affect growth and body weight of mice, though likely through different mechanisms
Rcan2 regulates osteoblast function and its expression in bone is regulated by thyroid status in vivo
an Rcan2-dependent mechanism which regulates food intake and promotes weight gain through a leptin (show LEP Proteins)-independent pathway
Genetic inhibition of calcineurin in Zaki-4 transgenic mice induces diastolic dysfunction in mice with chronic pressure overload.
This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
regulator of calcineurin 2
, Down syndrome critical region gene 1-like 1
, Down syndrome candidate region 1-like 1
, myocyte-enriched calcineurin-interacting protein 2
, thyroid hormone-responsive (skin fibroblasts)
, thyroid hormone-responsive protein ZAKI-4
, calcineurin inhibitory protein ZAKI-4
, down syndrome candidate region 1-like protein 1
, myocyte-enriched calcineurin interactin protein 2
, Down syndrome critical region gene1-like 1
, Down syndrome critical region gene 1-like 1 protein
, down syndrome candidate region 1-like 1