Regulator of G Protein Signaling 7 Binding Protein Proteins (RGS7BP)

Human Regulator of G Protein Signaling 7 Binding Protein (RGS7BP) interaction partners

1. Data (including data from studies using transgenic mice) suggest that R7BP-RGS7 heterotrimers interact with Galpha13 (show GNA13 Proteins) to augment signaling pathways in neurons that regulate neurite morphogenesis. (R7BP = RGS7 family binding protein; RGS7 = regulator of G-protein signaling 7 protein; Galpha13 (show GNA13 Proteins) = GTP-binding protein alpha subunit (show POLG Proteins) 13)

2. R7-binding protein had a strong inhibitory effect on homo-oligomerization of RGS7.

3. BL3-ht2 of RGS7BP may be an important genetic variant associated with AERD. The haplotype of block 3 may play a protective role against aspirin hypersensitivity in asthma, perhaps by altering the responsiveness of muscarinic receptors.

4. cytoplasmic RGS7*Gbeta5 (show GNB5 Proteins)*R7BP heterotrimers and RGS7*Gbeta5 (show GNB5 Proteins) heterodimers are equivalently inefficient regulators of G protein-coupled receptor (show ADRA1A Proteins) signaling relative to plasma membrane-bound heterotrimers bearing palmitoylated R7BP.

5. the successful purification of functionally intact Gbeta5 (show GNB5 Proteins)-free recombinant RGS11 (show RGS11 Proteins) was reported that differentially interact with R7BP and Galpha (show SUCLG1 Proteins)(oa).

Mouse (Murine) Regulator of G Protein Signaling 7 Binding Protein (RGS7BP) interaction partners

1. The results of this study indicated that R7bp is a key regulator of itch sensation and suggest the potential targeting of R7bp-dependent GTPase activating protein (show RASA1 Proteins) activity as a novel therapeutic strategy for pathological itch

2. R7-binding protein had a strong inhibitory effect on homo-oligomerization of RGS7.

3. R7BP-dependent regulation of R7-RGS (show PITX2 Proteins) proteins shapes specific aspects of light-evoked and spontaneous activity of retinal ganglion cells in mature and developing retina.

4. GIRK modulation occurs by channel assembly with R7-RGS (show PITX2 Proteins)/Gbeta5 (show GNB5 Proteins) complexes under allosteric control of R7 RGS (show PITX2 Proteins)-binding protein (R7BP).

5. R7BP is a negative modulator of the analgesic and locomotor activating actions of morphine that contributes to the development of morphine tolerance.

6. regulator of G-protein signalling 7 binding protein contributes significantly to the nuclear localization of endogenous G beta(5)/R7-RGS (show PITX2 Proteins) complex in brain

7. These results indicate that dopamine signaling in the striatum is controlled by concerted interplay between two RGS (show PITX2 Proteins) proteins, RGS7 and RGS9-2 (show RGS Proteins), which are balanced by a common subunit, R7BP.

8. All four R7 RGS (show PITX2 Proteins) proteins co-precipitate with R7BP from brain extracts and recombinant R7 proteins bind recombinant R7BP with high efficiency

9. Review. R7BP transduces signals directly from receptors and G proteins at the plasma membrane to the nucleus, and this plasma membrane-nuclear shuttling is controlled by reversible palmitoylation of R7BP.

10. R7BP controls expression of regulator of G-protein signaling (RGS)9-2 expression at the posttranslational level.