Regulatory Factor X 3 Proteins (RFX3)

Human Regulatory Factor X 3 (RFX3) interaction partners

1. FOXJ1 (show FOXJ1 Proteins) is an important regulator of cilia gene expression during ciliated cell differentiation, with RFX3 as a transcriptional co-activator to FOXJ1 (show FOXJ1 Proteins).

2. Taken together, this study suggests ciliogenic RFX (show RFX1 Proteins) transcription factors regulate FGF-1B promoter activity and the maintenance of F1BGFP(+) NSPCs and GBM-SCs (show TWIST1 Proteins).

3. Data show that two regulatory factor for X box (RFX1 (show RFX1 Proteins) and 3) binding sites in exon1 of both the mouse and human microtubule-associated protein (MAP1A (show MAP1A Proteins)) gene are important for effective transcriptional repression in non-neuronal cells.

4. novel role for the RFX family of transcription factors as modulators of Ras signalling in epithelial cells.

5. RFX3 controls the expression of genes involved in primary ciliary dyskinesia.

Mouse (Murine) Regulatory Factor X 3 (RFX3) interaction partners

1. The ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating the patterning of prethalamus and ventral telencephalon

2. This study unravels a crucial role of RFX3 during early brain development by indirectly regulating GLI3 (show GLI3 Proteins) activity, which leads to FGF8 (show FGF8 Proteins) upregulation and ultimately to disturbed distribution of guidepost neurons required for CC morphogenesis

3. High dosage of resveratrol pretreatment inhibited the injury-induced up-regulation of eIF2alpha (show EIF2A Proteins)-CHOP (show DDIT3 Proteins) and IRE1alpha (show ERN1 Proteins)-XBP1 (show XBP1 Proteins) pathways.

4. Rfx3 is required for the differentiation and function of mature beta-cells and regulates the beta-cell promoter of the glucokinase (show GCK Proteins) gene.

5. RFX3 may play roles in haploid cells during mouse spermatogenesis

6. RFX3 is essential for the differentiation of nodal monocilia and hence for LR body axis determination.

7. These results demonstrate that regulatory factor X3 is necessary for ciliated ependymal cell differentiation in the mouse.

8. RFX3 participates in the mechanisms that govern pancreatic endocrine cell differentiation and the presence of primary cilia on islet cells may play a key role in this process.

9. RFX3 is also necessary for biogenesis of motile cilia.