Reticulocalbin 1, EF-Hand Calcium Binding Domain Proteins (RCN1)

Mouse (Murine) Reticulocalbin 1, EF-Hand Calcium Binding Domain (RCN1) interaction partners

1. In the adult mice, RCAN1 was mainly expressed in the neuropil throughout the brain.

Human Reticulocalbin 1, EF-Hand Calcium Binding Domain (RCN1) interaction partners

1. RCN1 may promote cell survival and serve as a useful target for cancer therapy.

2. irradiated tumor cells were observed to significantly up-regulate the expression of calcium-binding proteins CALM1, CALU, and RCN1, suggesting important roles for these mediators in promoting tumor cell survival during hypoxia

3. RCN1 expression was not statistically significantly different to healthy controls but was associated with disease activity score and could be used as a stratification biomarker for systemic sclerosis patients.

4. reticulocalbin-1 plays a key role in the development of doxorubicin-associated resistance

5. Ca(2+) binding caused an increase in the alpha-helix content of human RCN1. On the other hand, RCN1 did not change the structure with Mg.

6. a promising role of RCN1 as a possible marker in Renal cell carcinoma

7. reticulocalbin-1 may be an important molecule in understanding lymphatic endothelial cells in tumors function and control of lymphatic metastasis.

8. Increased RCN1 is associated with systemic sclerosis and nephrogenic systemic fibrosis.

9. deletion of Rcn1 directly or indirectly contributes to the eye phenotype in Pax6 contiguous gene deletions

10. RCN1 also is expressed on the cell surface of several endothelial cell lines, including human dermal microvascular endothelial cells (HDMVECs), bone marrow endothelial cells (BMEC), and transformed human bone marrow endothelial cells (TrHBMEC).

11. Data show that calumenin in the presence of calcium binds specifically to thrombospondin-1, but closely-related reticulocalbin does not form a similar complex.