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Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. Additionally we are shipping RCN1 Antibodies (39) and RCN1 Kits (4) and many more products for this protein.
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In the adult mice, RCAN1 was mainly expressed in the neuropil throughout the brain.
RCN1 may promote cell survival and serve as a useful target for cancer therapy.
irradiated tumor cells were observed to significantly up-regulate the expression of calcium-binding proteins CALM1, CALU, and RCN1, suggesting important roles for these mediators in promoting tumor cell survival during hypoxia
RCN1 expression was not statistically significantly different to healthy controls but was associated with disease activity score and could be used as a stratification biomarker for systemic sclerosis patients.
reticulocalbin-1 plays a key role in the development of doxorubicin-associated resistance
Ca(2+) binding caused an increase in the alpha-helix content of human RCN1. On the other hand, RCN1 did not change the structure with Mg.
a promising role of RCN1 as a possible marker in Renal cell carcinoma
reticulocalbin-1 may be an important molecule in understanding lymphatic endothelial cells in tumors function and control of lymphatic metastasis.
Increased RCN1 is associated with systemic sclerosis and nephrogenic systemic fibrosis.
deletion of Rcn1 directly or indirectly contributes to the eye phenotype in Pax6 contiguous gene deletions
RCN1 also is expressed on the cell surface of several endothelial cell lines, including human dermal microvascular endothelial cells (HDMVECs), bone marrow endothelial cells (BMEC), and transformed human bone marrow endothelial cells (TrHBMEC).
Data show that calumenin in the presence of calcium binds specifically to thrombospondin-1, but closely-related reticulocalbin does not form a similar complex.
Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate cancer cell lines this protein localizes to the plasma membrane.
, proliferation-inducing gene 20