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RTN3 belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. Additionally we are shipping Reticulon 3 Antibodies (46) and and many more products for this protein.
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Here, the authors identified reticulon 3 (RTN3) as a specific receptor for the degradation of endoplasmic reticulum tubules. None of the other reticulon family members have the ability to induce fragmentation of endoplasmic reticulum tubules during starvation.
RTN3 was critical for EGFR (show EGFR Proteins)-nonclathrin endocytosis (NCE), promoting the creation of plasma membrane - endoplasmic reticulum contact sites that were required for the formation and/or maturation of NCE invaginations.
This study demonstrated that higher intrahepatic RTN3 levels were independently associated with higher intrahepatic HCV viral loads and genotype 1 in HCV-related hepatocellular carcinoma
These results suggested that RTN3 modulates primordial germ cell migration through interaction with, and regulation of, CXCR4 (show CXCR4 Proteins).
RTN 3 interacts with the N-terminal domain of EV71 2C, which is crucial for replication of viral RNA. [Review]
Authors demonstrated that the second transmembrane region of RTN3 competed for, and bound to, the AH2 domain of hepatitis C virus NS4B, thus abolishing NS4B self-interaction and leading to the downregulation of viral replication.
In Alzheimer's disease transgenic mouse models, RTN3 deficiency facilitates amyloid deposition.
This study demonistrated that Reduction of beta-amyloid accumulation by reticulon 3.
successful prevention of imunoreactive dystrophic neurites formation should be initiated before RTN3 aggregation
we hypothesis that RTN3 may participate in the continuous process of circulating monocyte recruitment in atherosclerosis.
RTN3 expression is a mediator of RBM3 (show RBM3 Proteins)-induced neuroprotection, controlled by novel mechanisms of escape from translational inhibition on cooling.
altered RTN3 levels can impact the axonal transport of BACE1 (show BACE Proteins) and demonstrate that reducing axonal transport of BACE1 (show BACE Proteins) in axons is a viable strategy for decreasing BACE1 (show BACE Proteins) in axonal terminals and, perhaps, reducing amyloid deposition.
RTN3 negatively regulates autophagy to block the clearance of cytoplasmic PrP aggregates.
results show that reticulon 3 may play a role in the trafficking of the synaptic adhesion-like molecules family of adhesion molecules
cDNA of mouse reticulon 3 (mRTN3) was cloned. The gene was mapped at band B of chromosome 19.
RTN3 isoforms may contribute, by as yet unknown mechanisms, to neuronal survival and plasticity
Since other reports have shown that RTN4-A (show RTN4 Proteins) inhibits neuronal outgrowth and restricts the plasticity of the central nervous system, we speculate that RTN3-A1 might play certain roles in the central nervous system.
Transgenic mice overexpressing reticulon 3 develop neuritic abnormalities.
RTN3 co-immunoprecipitated with endogenous beta-site amyloid precursor protein-cleaving enzyme 1 (show BACE Proteins), confirming interactions between these two membrane proteins in the mouse brain
This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12.
ASY interacting protein
, NSP-like protein 2
, NSP-like protein II
, homolog of ASY protein
, neuroendocrine-specific protein-like 2
, neuroendocrine-specific protein-like II
, Nsp-like II
, reticulon 3
, reticulon protein 3
, localized to ER
, reticulon family protein