Reticulon 3 Proteins (RTN3)

RTN3 belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. Additionally we are shipping Reticulon 3 Antibodies (46) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RTN3 10313 O95197
RTN3 20168 Q9ES97
Rat RTN3 RTN3 140945 Q6RJR6
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Top Reticulon 3 Proteins at

Showing 5 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Orang-Utan His tag   1 mg Log in to see 60 to 71 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days

RTN3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Reticulon 3 (RTN3) Interaction Partners

Human Reticulon 3 (RTN3) interaction partners

  1. RTN3 regulates very low density lipoprotein (VLDL) secretion by controlling VLDL transport vesicle-mediated endoplasmic reticulum-to-Golgi transport of nascent VLDL.

  2. Here, the authors identified reticulon 3 (RTN3) as a specific receptor for the degradation of endoplasmic reticulum tubules. None of the other reticulon family members have the ability to induce fragmentation of endoplasmic reticulum tubules during starvation.

  3. RTN3 was critical for EGFR-nonclathrin endocytosis (NCE), promoting the creation of plasma membrane - endoplasmic reticulum contact sites that were required for the formation and/or maturation of NCE invaginations.

  4. This study demonstrated that higher intrahepatic RTN3 levels were independently associated with higher intrahepatic HCV viral loads and genotype 1 in HCV-related hepatocellular carcinoma

  5. These results suggested that RTN3 modulates primordial germ cell migration through interaction with, and regulation of, CXCR4.

  6. RTN 3 interacts with the N-terminal domain of EV71 2C, which is crucial for replication of viral RNA. [Review]

  7. Authors demonstrated that the second transmembrane region of RTN3 competed for, and bound to, the AH2 domain of hepatitis C virus NS4B, thus abolishing NS4B self-interaction and leading to the downregulation of viral replication.

  8. In Alzheimer's disease transgenic mouse models, RTN3 deficiency facilitates amyloid deposition.

  9. This study demonistrated that Reduction of beta-amyloid accumulation by reticulon 3.

  10. successful prevention of imunoreactive dystrophic neurites formation should be initiated before RTN3 aggregation

  11. we hypothesis that RTN3 may participate in the continuous process of circulating monocyte recruitment in atherosclerosis.

  12. we examined reticulon-3 expression in cases of Alzheimer's disease, Parkinson's disease, and diffuse Lewy body disease

  13. Reticulons, the only molecular so far to participate in all three apoptosis signaling pathways, may be a novel player in the progress of atherosclerosis.

  14. common genetic variation in the BACE1-interacting proteins, RTN3 an PPIL2, does not influence platelet b-secretase activity or susceptibility to Alzheimer's disease in this population.

  15. CRELD1 could partly change the localization of RTN3 from the endoplasmic reticulum to the plasma membrane and modulate the apoptotic activity of RTN3 through binding with it.

  16. RTN3 mutants w/o the N-terminal or C-terminal or loop domain bound BACE1 like wild-type & reduced Abeta40/42 secretion. Mutants of the the 1st or 2d potential transmembrane domains bound BACE1 but failed to inhibit Abeta secretion.

  17. The ASYIP protein co-localizes with ASY in the endoplasmic reticulum. Characterization of the ASYIP gene helps to clarify ASY-induced apoptosis or Nogo-involved inhibition of neuronal regeneration in the central nervous system.

  18. RTN3 isoforms may contribute, by as yet unknown mechanisms, to neuronal survival and plasticity

  19. apoptosis-inducing protein, HAP, induces bacterial cell death [HAP, homolog of ASY protein]

  20. These results suggest that RTN3 plays a role in membrane trafficking in the early secretory pathway.

Mouse (Murine) Reticulon 3 (RTN3) interaction partners

  1. RTN3 expression is a mediator of RBM3-induced neuroprotection, controlled by novel mechanisms of escape from translational inhibition on cooling.

  2. altered RTN3 levels can impact the axonal transport of BACE1 and demonstrate that reducing axonal transport of BACE1 in axons is a viable strategy for decreasing BACE1 in axonal terminals and, perhaps, reducing amyloid deposition.

  3. RTN3 negatively regulates autophagy to block the clearance of cytoplasmic PrP aggregates.

  4. results show that reticulon 3 may play a role in the trafficking of the synaptic adhesion-like molecules family of adhesion molecules

  5. cDNA of mouse reticulon 3 (mRTN3) was cloned. The gene was mapped at band B of chromosome 19.

  6. RTN3 isoforms may contribute, by as yet unknown mechanisms, to neuronal survival and plasticity

  7. Since other reports have shown that RTN4-A inhibits neuronal outgrowth and restricts the plasticity of the central nervous system, we speculate that RTN3-A1 might play certain roles in the central nervous system.

  8. Transgenic mice overexpressing reticulon 3 develop neuritic abnormalities.

  9. RTN3 co-immunoprecipitated with endogenous beta-site amyloid precursor protein-cleaving enzyme 1, confirming interactions between these two membrane proteins in the mouse brain

Reticulon 3 (RTN3) Protein Profile

Protein Summary

This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12.

Gene names and symbols associated with Reticulon 3 Proteins (RTN3)

  • reticulon 3 (RTN3)
  • reticulon 3 (Rtn3)
  • reticulon 3 (rtn3)
  • reticulon 3 (rnt3)
  • reticulon 3 L homeolog (rtn3.L)
  • reticulon-3 (LOC107131155)
  • reticulon 3 S homeolog (rtn3.S)
  • asyip protein
  • hap protein
  • MGC56439 protein
  • nspl2 protein
  • nsplii protein
  • rtn3 protein
  • rtn3-a protein
  • rtn3-a1 protein
  • rtn3-b protein
  • RTN3w protein
  • XRTN3 protein
  • zgc:56439 protein
  • zgc:77630 protein

Protein level used designations for Reticulon 3 Proteins (RTN3)

ASY interacting protein , NSP-like protein 2 , NSP-like protein II , homolog of ASY protein , neuroendocrine-specific protein-like 2 , neuroendocrine-specific protein-like II , reticulon-3 , Nsp-like II , reticulon 3 , reticulon protein 3 , RTN3-A1w , reticulon-3-like , RTN3.1 , localized to ER , reticulon family protein , reticulon-3-A , RTN3.2 , reticulon-3-B

10313 Homo sapiens
20168 Mus musculus
140945 Rattus norvegicus
359721 Bos taurus
394047 Danio rerio
451281 Pan troglodytes
476043 Canis lupus familiaris
549516 Xenopus (Silurana) tropicalis
619183 Macaca mulatta
654271 Takifugu rubripes
100137054 Salmo salar
100170398 Ovis aries
100172388 Pongo abelii
100405288 Callithrix jacchus
100476123 Ailuropoda melanoleuca
100512087 Sus scrofa
100593953 Nomascus leucogenys
444146 Xenopus laevis
107131155 Bos taurus
447369 Xenopus laevis
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