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RBP1 encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Additionally we are shipping Retinol Binding Protein 1, Cellular Antibodies (127) and Retinol Binding Protein 1, Cellular Kits (26) and many more products for this protein.
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Human RBP1 Protein expressed in HEK-293 Cells - ABIN2730759
Arnold, Kent, Hogarth, Schlatt, Prasad, Haenisch, Walsh, Muller, Griswold, Amory, Isoherranen: Importance of ALDH1A enzymes in determining human testicular retinoic acid concentrations. in Journal of lipid research 2015
Low CRBP1 expression is associated with low radiation sensitivity in rectal cancer.
This conformational flexibility of human apo (show C9orf3 Proteins)-CRBP1 facilitates interaction with the ligands, whereas the more rigid holoprotein structure protects the labile retinoid moiety during vitamin A transport.
Hypermethylation of CRBP1 gene is associated with Epstein-Barr virus-associated gastric carcinomas.
Further studies are needed to explore new therapeutic strategies aimed at restoring CRBP-1-mediated intracellular retinol trafficking and the meaning of CRBP-1 expression in cancer patients screening for a more personalized and efficacy retinoid therapy
RBP1 expression was reduced in tissue and endometrial stromal cells derived from endometritis lesions versus eutopic endometruim in humans and mice.
Functional hepatic stellate cells coexpressing both LRAT (show LRAT Proteins) and CRBP-1, that continue to maintain the ability to store vitamin A, contribute in part to the development of portal and parenchymal fibrogenesis in patients with viral hepatitis.
Factors involved in the retinoid pathway, in particular upregulation of CRBP, CRABP1 (show CRABP1 Proteins) and CRABP2 (show CRABP2 Proteins), also showed differential expression in tumors with different histological subtypes
CRBP-1 loss in G2/G3 ovarian carcinomas and increased apoptotic susceptibility to retinoids.
Suggest CRBP1 gene as a tumor suppressor gene for cervical cancer.
RBP1 promoter hypermethylation is found in nearly all IDH1 (show IDH1 Proteins) and IDH2 (show IDH2 Proteins) mutant gliomas Because RBP1 is involved in retinoic acid synthesis, results suggest that dysregltion of RA metabolism may contribute to glioma formation along the IDH1 (show IDH1 Proteins)/IDH2 (show IDH2 Proteins)-mutant pathway
The localization of CRBP1 within the retina and its demonstrated role in modulating the proper folding of nascent outer segment membranes through retinoic acid further elucidates the role of these cells in directly influencing photoreceptor physiology.
genetic deletion of RBP1 and RBP2 (show RBP2 Proteins) did not impair synapse ultrastructure of ribbon-type synapses formed between rod bipolar cells (RBCs (show SSU1 Proteins)) and amacrine type-2 (AII (show ARG2 Proteins)) cells in the mouse retina but dramatically reduced the density of presynaptic Ca(2 (show CA2 Proteins)+) channels, decreased and desynchronized evoked neurotransmitter release
CrbpI loss disrupts all-trans retinoic acid homeostasis in mammary tissue, resulting in microenvironmental defects similar to those observed at the early stages of tumorigenesis.
glucose homeostasis and energy metabolism rely on Rbp1 expression and its moderation of pancreas retinol and of the autacoid 9-cis-retinoic acid.
As such, the effects of RBP1 on these processes are mediated through both regulation of Runx2 (show RUNX2 Proteins) expression and transcriptional activity.
CRBP-I is a cytosolic protein specifically expressed in preadipocytes that regulates adipocyte differentiation in part by affecting PPAR gamma (show PPARG Proteins) activity.
This murine RBP (show RBP4 Proteins)-null model may have relevance to fetal development in human populations with inadequate retinoid intake.
Crbp1-/- mice also exhibited increased metabolism of a dose of retinol into retinoic acid, and this increased metabolism was not observed in Crbp1-/-/Adh1 (show ADH1A Proteins)-/- mice
Data show that while vitamin A-replete retinol binding protein (rbp)-cryptochrome(cry) 1- and 2-knockout mice are light responsive, vitamin A-depleted knockout mice lose most behavioral and molecular responses to light.
Epigenetic silencing of cellular CRBPI is associated with nasopharyngeal carcinoma
This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. Multiple transcript variants encoding different isoforms have been found for this gene.
, cellular retinol-binding protein I
, retinol-binding protein 1
, retinol-binding protein 1, cellular
, retinol binding protein 1, cellular
, cellular retinol binding protein 1
, LOW QUALITY PROTEIN: retinol-binding protein 1