Retinoschisin 1 Proteins (RS1)

RS1 encodes an extracellular protein that plays a crucial role in the cellular organization of the retina. Additionally we are shipping Retinoschisin 1 Antibodies (18) and Retinoschisin 1 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RS1 6247 O15537
Mouse RS1 RS1 20147 Q9Z1L4
Rat RS1 RS1 100125595  
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Top Retinoschisin 1 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
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Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 11 Days
$341.00
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Yeast Takifugu rubripes His tag   1 mg Log in to see 60 to 71 Days
$2,663.83
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Escherichia coli (E. coli) Human S tag,His tag 100 μg Log in to see 15 to 18 Days
$640.00
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RS1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,

More Proteins for Retinoschisin 1 (RS1) Interaction Partners

Human Retinoschisin 1 (RS1) interaction partners

  1. These results establish that extracellular delivery of RS1 rescues the structural and functional deficits in the Rs1h knockout mouse model and that this ex vivo gene therapy approach can inhibit progression of disease.

  2. Taken together, RS1 mutation was found to segregate with retinoschisis phenotype while none of the other identified variations were co-segregating with the systemic defects. Hereby, we infer that the multisystemic defects harbored by the patient are a rare coexistence of XLRS, developmental delay, sensorineural hearing loss, and reduced axial tone reported for the first time in the literature.

  3. Results suggest a regulatory effect of retinoschisin on Na/K-ATPase (show ATP1A1 Proteins) signaling and localization, whereas Na/K-ATPase (show ATP1A1 Proteins)-dysregulation caused by retinoschisin deficiency could represent an initial step in XLRS pathogenesis.

  4. these findings support distinct mechanisms of pathology for two classes of X-linked retinoschisis -associated mutations in the retinoschisin assembly.

  5. A novel RS1 (97delT) mutation was identified in a Taiwanese family with X-linked retinoschisis (XLRS). This finding expands the RS1 mutation spectrum and may help to further understand the molecular pathogenesis of XLRS.

  6. A novel RS1 (304C > T) mutation in a Taiwanese family with X-linked retinoschisis.

  7. We identified a novel causative mutation of RS1 in a Chinese family with X-linked juvenile retinoschisis.

  8. the disease and p.Arg197Cys mutation of RS1 gene was identified

  9. Sequencing of the RS1 gene identified 16 mutations, nine of which were novel.

  10. Severe RS1 missense changes were associated with a lower ERG b (show ERG Proteins)/a ratio than were mild changes in X-linked retinoschisis suggesting the effect of the mutations on protein structure influenced the retinal dysfunction.

Mouse (Murine) Retinoschisin 1 (RS1) interaction partners

  1. Results suggest a regulatory effect of retinoschisin on Na/K-ATPase (show ATP1A1 Proteins) signaling and localization, whereas Na/K-ATPase (show ATP1A1 Proteins)-dysregulation caused by retinoschisin deficiency could represent an initial step in XLRS pathogenesis.

  2. retinoschisin is a novel regulator of MAP kinase (show MAPK1 Proteins) signalling and exerts an anti-apoptotic effect on retinal cells.

  3. Based on this structure, we propose that RS1 couples neighboring membranes together through octamer-octamer contacts, perhaps modulated by interactions with other membrane components.

  4. Changes in Rs1-knockout mice were associated with age related alterations in photoreceptor morphology and transcription factor expression that suggest delayed photoreceptor maturation.

  5. Time line analysis after short-term treatment with dorzolamide failed to show short-, intermediate-, or long-term evidence of structural improvement in Rs1h(-/y) mice.

  6. The results of this study demonstrated that loss of Rs1 gene function has a significant impact on the expression of photoreceptor transcription factor network genes, and morphological and functional defects in young (P21) Rs1-KO mice.

  7. RS1 is needed for preservation of synaptic structures but not synaptogenesis in retinoschisis model.

  8. Data suggest that a CpG island enhancer and two CBRs may act in a combinatorial fashion to fine-tune RS1 transcript levels in the retina.

  9. Retinoschisin, the protein involved in the pathogenesis of X-linked juvenile retinoschisis, membrane association is severely impaired in the absence of ATP1A3 (show ATP1A3 Proteins) and ATP1B2 (show ATP1B2 Proteins).

  10. Upon Rs1 adsorption, phosphatidylserine and phosphatidylserine-containing mixed lipid bilayers underwent fast and extensive reorganization.

Retinoschisin 1 (RS1) Protein Profile

Protein Summary

This gene encodes an extracellular protein that plays a crucial role in the cellular organization of the retina. The encoded protein is assembled and secreted from photoreceptors and bipolar cells as a homo-oligomeric protein complex. Mutations in this gene are responsible for X-linked retinoschisis, a common, early-onset macular degeneration in males that results in a splitting of the inner layers of the retina and severe loss in vision.

Gene names and symbols associated with Retinoschisin 1 Proteins (RS1)

  • retinoschisin 1 (RS1)
  • retinoschisin 1 S homeolog (rs1.S)
  • retinoschisin 1 (rs1)
  • retinoschisis (X-linked, juvenile) 1 (human) (Rs1)
  • retinoschisin 1a (rs1a)
  • retinoschisin 1 (Rs1)
  • RS protein
  • rs1 protein
  • Rs1h protein
  • tmgc1 protein
  • Xlrs1 protein
  • zgc:92703 protein

Protein level used designations for Retinoschisin 1 Proteins (RS1)

X-linked juvenile retinoschisis protein , retinoschisin , retinoschisis (X-linked, juvenile) 1 , retinoschisin 1 , retinoschisin-like , X-linked juvenile retinoschisis protein homolog , retinoschisis 1 homolog

GENE ID SPECIES
6247 Homo sapiens
491762 Canis lupus familiaris
615193 Bos taurus
748866 Pan troglodytes
779332 Xenopus laevis
100124900 Xenopus (Silurana) tropicalis
100126075 Oryctolagus cuniculus
100127441 Sus scrofa
100423325 Macaca mulatta
20147 Mus musculus
445044 Danio rerio
100125595 Rattus norvegicus
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