anti-Ring Finger Protein 139 (RNF139) Antibodies

The protein encoded by RNF139 is a multi-membrane spanning protein containing a RING-H2 finger. Additionally we are shipping Ring Finger Protein 139 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RNF139 11236 Q8WU17
RNF139 75841 Q7TMV1
RNF139 315000  
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Top anti-Ring Finger Protein 139 Antibodies at

Showing 10 out of 59 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RNF139 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  MCF7 cell lysate RNF139 is supported by BioGPS gene expression data to be expressed in MCF7 100 μL 2 to 3 Days
Human Goat Un-conjugated IHC, ELISA, WB (1µg/ml) staining of Human Skeletal Muscle lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 to 7 Days
Human Goat Un-conjugated ELISA, IHC, IHC (p), WB 50 μg 11 to 14 Days
Bat Rabbit Un-conjugated IHC, IHC (p), WB 100 μL 11 to 14 Days
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to RNF139 on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 3 ug/ml] RNF139 monoclonal antibody (M01), clone 3D10 Western Blot analysis of RNF139 expression in HepG2 . 100 μg 11 to 12 Days
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (37.11 KDa) . 50 μL 11 to 12 Days
Dog Goat Un-conjugated EIA, IHC (p), WB   0.1 mg 4 to 8 Days
Human Mouse Un-conjugated ELISA, WB 100 μg 11 to 14 Days
Human Rabbit Un-conjugated ELISA, WB 100 μL 2 to 3 Days
Human Rabbit Un-conjugated WB RNF139 antibody used at 1 ug/ml to detect target protein. 50 μg 9 to 11 Days

Top referenced anti-Ring Finger Protein 139 Antibodies

  1. Human Polyclonal RNF139 Primary Antibody for ELISA, WB - ABIN564886 : Brauweiler, Lorick, Lee, Tsai, Chan, Weissman, Drabkin, Gemmill: RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene. in Oncogene 2007 (PubMed)
    Show all 4 Pubmed References

  2. Human Monoclonal RNF139 Primary Antibody for IHC (p), ELISA - ABIN564887 : Adams, Simms, Abdelhamed, Dawe, Szymanska, Logan, Wheway, Pitt, Gull, Knowles, Blair, Cross, Sayer, Johnson: A meckelin-filamin A interaction mediates ciliogenesis. in Human molecular genetics 2012 (PubMed)

More Antibodies against Ring Finger Protein 139 Interaction Partners

Human Ring Finger Protein 139 (RNF139) interaction partners

  1. INSIG1 coordinated with another ligase, translocation in renal carcinoma chromosome 8 (TRC8), and promoted Gag degradation through the lysosome pathway.

  2. TRC8 and MARCH6 depletion altered the turnover of the tail-anchored protein heme oxygenase-1.

  3. Low RNF139 expression is associated with progression of tongue cancer.

  4. interaction with Bag1 then shifts hERG degradation to the membrane-anchored E3 ligase TRC8 and its E2-conjugating enzyme Ube2g2, as determined by siRNA screening

  5. TRC8 and TMEM129 are endoplasmic reticulum-associated degradation ubiquitin E3 ligases for viral and cellular targeting of MHC class I. (Review)

  6. TRC8 suppresses tumorigenesis through targeting heme oxygenase-1 for ubiquitination and degradation.

  7. TRC8 function may provide a regulatory link between the lipid and protein biosynthetic pathways.

  8. TRC8 modulation of sterol response element binding protein activity comprises a novel regulatory link between growth control and the cholesterol/lipid homeostasis pathway.

  9. The presence of diploid and tetraploid tumor cells with and without TRC8 deletions on the nontranslocated chromosome suggest that loss of the remaining normal allele of TRC8 may contribute to tumor development at later stages.

  10. TRC8 is a novel sterol-sensing endoplasmic reticulum membrane protein that hinders SREBP-2 processing through interaction with SREBP-2 and SCAP, regulating its own turnover rate by means of its E3 ubiquitin ligase activity

  11. Data show that the TRC8 E3 ligase is required for MHC I dislocation from the ER and identify a new complex associated with mammalian ERAD.

Ring Finger Protein 139 (RNF139) Antigen Profile

Protein Summary

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.

Gene names and symbols associated with RNF139

  • ring finger protein 139 (RNF139) antibody
  • ring finger protein 139 (Rnf139) antibody
  • ring finger protein 139 (rnf139) antibody
  • ring finger protein 139 S homeolog (rnf139.S) antibody
  • 4930555P18Rik antibody
  • HRCA1 antibody
  • RCA1 antibody
  • rnf139 antibody
  • TRC8 antibody
  • zgc:175173 antibody

Protein level used designations for RNF139

E3 ubiquitin-protein ligase RNF139 , multiple membrane spanning receptor TRC8 , patched related protein translocated in renal cancer , translocation in renal carcinoma on chromosome 8 protein , RING finger protein 139 , ring finger protein 139 S homeolog

11236 Homo sapiens
75841 Mus musculus
315000 Rattus norvegicus
420338 Gallus gallus
609422 Canis lupus familiaris
100067392 Equus caballus
100156613 Sus scrofa
788471 Bos taurus
100447707 Pongo abelii
100734055 Cavia porcellus
100357210 Oryctolagus cuniculus
100144552 Danio rerio
444792 Xenopus laevis
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